The Cytochrome P450 Gene Super-family in Drosophila melanogaster; Gene Function and Insecticide Resistance. The cytochrome P450 (Cyp) gene super-family is represented by over 90 sequences in the genome of the vinegar fly, Drosophila melanogaster. To date, four Cyp genes are found to be involved in insecticide resistance. The function of the majority of Cyp genes is unknown. This project will investigate the function and regulation of D. melanogaster Cyp genes, linking the fly's genotype to its ....The Cytochrome P450 Gene Super-family in Drosophila melanogaster; Gene Function and Insecticide Resistance. The cytochrome P450 (Cyp) gene super-family is represented by over 90 sequences in the genome of the vinegar fly, Drosophila melanogaster. To date, four Cyp genes are found to be involved in insecticide resistance. The function of the majority of Cyp genes is unknown. This project will investigate the function and regulation of D. melanogaster Cyp genes, linking the fly's genotype to its phenotype. By studying the effects of Cyp genes on fly survival, Cyp gene expression and regulation, and expressing selected Cyp genes in a yeast expression system, we will enhance our understanding of Cyp gene function and evolution.Read moreRead less
The Evolution of Gas in Galaxy Groups. The evolution of gas in galaxy groups is poorly understood, but is crucial to understanding galaxy evolution. This project provides a training opportunity for a talented postdoc to conduct the first `multiwavelength census' of southern galaxy groups, perform simulations and make predictions of group properties at early times. We will better understand the evolutionary processes in groups and provide a `local anchor' for future surveys. The knowledge gained ....The Evolution of Gas in Galaxy Groups. The evolution of gas in galaxy groups is poorly understood, but is crucial to understanding galaxy evolution. This project provides a training opportunity for a talented postdoc to conduct the first `multiwavelength census' of southern galaxy groups, perform simulations and make predictions of group properties at early times. We will better understand the evolutionary processes in groups and provide a `local anchor' for future surveys. The knowledge gained will feed directly into the design of the future Square Kilometre Array, and raise Australia's profile in this $1B project. We exploit Australia's best astronomical facilities, and establish a new University-CSIRO collaboration.
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Development of Novel Pesticidal Agents. We have discovered a family of naturally occurring plant proteins called the cyclotides that have potent insecticidal activity against Helicoverpa species, one of the major pests on cotton and corn in Australia and world wide. Preliminary evidence has shown that they also have activity against major pests to livestock in Australia, including sheep blowflies. To develop these proteins as potential pesticidal agents it is necessary to understand the struct ....Development of Novel Pesticidal Agents. We have discovered a family of naturally occurring plant proteins called the cyclotides that have potent insecticidal activity against Helicoverpa species, one of the major pests on cotton and corn in Australia and world wide. Preliminary evidence has shown that they also have activity against major pests to livestock in Australia, including sheep blowflies. To develop these proteins as potential pesticidal agents it is necessary to understand the structural basis for their activity. We will do this by chemically synthesising peptides with selected residues mutated to determine their effects on activity.Read moreRead less
DROP DEFORMATION IN CONFINED MICROFLUIDIC GEOMETRIES. Increasingly, high technology applications in biotechnology and microtechnology industries need to process complex (non-Newtonian) fluids with dispersed particles/droplets in channels as small as several microns (microfluidics). A computational fluid dynamic model of non-Newtonian droplet deformation in microfluidic geometries will be developed, and validated using experimental measurements of the flow field in this project. The aim is to und ....DROP DEFORMATION IN CONFINED MICROFLUIDIC GEOMETRIES. Increasingly, high technology applications in biotechnology and microtechnology industries need to process complex (non-Newtonian) fluids with dispersed particles/droplets in channels as small as several microns (microfluidics). A computational fluid dynamic model of non-Newtonian droplet deformation in microfluidic geometries will be developed, and validated using experimental measurements of the flow field in this project. The aim is to understand and quantify factors influencing droplet deformation. Coupling non-Newtonian characteristics with microfluidic geometries will allow the continuous manufacture of micro-particles of specified size and shape for existing and new applications, and will provide guidance for further extending the process to nano-particle manufacture.Read moreRead less
Atomisation and Combustion Physics of Australian Bio-oils. Australia is highly dependent on fossil fuels for energy production and transport, and this dependence is growing. Wide spread substitution of liquid hydrocarbon fuels by indigenous renewable bio-oil has the potential to improve Australian's energy outlook and assist in reaching greenhouse gas targets. Understanding the interrelationships between the physical and chemical properties of bio-oil, its atomisation, droplet formation and com ....Atomisation and Combustion Physics of Australian Bio-oils. Australia is highly dependent on fossil fuels for energy production and transport, and this dependence is growing. Wide spread substitution of liquid hydrocarbon fuels by indigenous renewable bio-oil has the potential to improve Australian's energy outlook and assist in reaching greenhouse gas targets. Understanding the interrelationships between the physical and chemical properties of bio-oil, its atomisation, droplet formation and combustion physics is fundamental to the delivery of an efficient and reliable combustion process using this fuel. Measurements using laser based diagnostics of the atomisation flow, droplet formation and combustion process will provide the experimental data to understand this complex interrelationship.Read moreRead less