Discovery Early Career Researcher Award - Grant ID: DE130100922
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Diamond cybernetics: nanocrystalline diamond for interfacing bionic devices with the human nervous system. Bionic devices will soon be used to treat disorders such as epilepsy, Parkinson's and depression. We will use diamond to create high resolution, permanent electrical connections between devices and the human nervous system. These diamond connections will preserve nerve health and make bionic devices more effective and able to last a lifetime.
Three-Dimensional Polymer Fibre Scaffolds with Functional Nano-structured Surface. The Partner Organisation to this research, CyGenics Ltd, is a world leader in cell biotechnology. A key challenge faced by the CyGenics and other biotech companies is the provision of tissue scaffolding materials that have the right three-dimensional macroscopic structure plus a suitable nano-structured surface micro-environment, similar to the natural extracellular matrix. This joint project combines expertise in ....Three-Dimensional Polymer Fibre Scaffolds with Functional Nano-structured Surface. The Partner Organisation to this research, CyGenics Ltd, is a world leader in cell biotechnology. A key challenge faced by the CyGenics and other biotech companies is the provision of tissue scaffolding materials that have the right three-dimensional macroscopic structure plus a suitable nano-structured surface micro-environment, similar to the natural extracellular matrix. This joint project combines expertise in polymer fibres, surface engineering and cell culture to tackle the key challenge. The outcome will help position the local polymer fibre and cell culture industries at the forefront of tissue scaffolding materials research and development. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100175
Funder
Australian Research Council
Funding Amount
$347,070.00
Summary
Three-dimensional additive bio-fabrication facility: printing bioprinters. This project aims to develop bioprinting systems that will provide new insights into fundamental biological processes. The 3D Additive Bio-Fabrication Facility - Printing Bioprinters capability will use 3D polymer and metal additive manufacturing technologies to create the next generation of bioprinting methodologies and 3D fabrication tools. It is the aim that these customised additive manufacturing systems will be used ....Three-dimensional additive bio-fabrication facility: printing bioprinters. This project aims to develop bioprinting systems that will provide new insights into fundamental biological processes. The 3D Additive Bio-Fabrication Facility - Printing Bioprinters capability will use 3D polymer and metal additive manufacturing technologies to create the next generation of bioprinting methodologies and 3D fabrication tools. It is the aim that these customised additive manufacturing systems will be used to produce structures wherein living cells are spatially organised in combination with appropriate biomaterials and bioactive components, such as drugs or growth factors, in order to influence subsequent biological behaviour.Read moreRead less
Establishing nanoscale design principles for non-viral genome engineering. This project aims to develop a bio-nanotechnology platform for non-viral genome engineering using dendronised polymers. The project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community. Outcomes from the project will also provide significant benefits, such as positioning Australia at the forefront of genome engineerin ....Establishing nanoscale design principles for non-viral genome engineering. This project aims to develop a bio-nanotechnology platform for non-viral genome engineering using dendronised polymers. The project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community. Outcomes from the project will also provide significant benefits, such as positioning Australia at the forefront of genome engineering.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100096
Funder
Australian Research Council
Funding Amount
$325,000.00
Summary
High resolution atomic force microscopy facility for bionanotechnology. This project aims to establish a collaborative high resolution atomic force microscopy facility. Nanoscale surface structure and the complex structure/mechanical-functional relationships underpin many biological processes, and understanding cell systems at the molecular level is expected to lead to scientific knowledge and therapeutic and other biotechnological applications. Expected outcomes include innovations in advanced ....High resolution atomic force microscopy facility for bionanotechnology. This project aims to establish a collaborative high resolution atomic force microscopy facility. Nanoscale surface structure and the complex structure/mechanical-functional relationships underpin many biological processes, and understanding cell systems at the molecular level is expected to lead to scientific knowledge and therapeutic and other biotechnological applications. Expected outcomes include innovations in advanced manufacturing in the pharmaceutical and medical devices industries, underpinning economic returns from new industries.Read moreRead less
Engineering drug transportation behaviour in polymeric gel systems. In collaboration with Seagull Technologies, this project aims to engineer, study and mathematically model ultrasound-assisted biomacromolecule transport behaviour within polymeric gel systems, which may be useful in new drug delivery methods. The intended outcome is a novel set of polymeric gel systems, which can reversibly bind a wide variety of drugs (small molecules, nucleic acid based drugs, proteins), in which drug release ....Engineering drug transportation behaviour in polymeric gel systems. In collaboration with Seagull Technologies, this project aims to engineer, study and mathematically model ultrasound-assisted biomacromolecule transport behaviour within polymeric gel systems, which may be useful in new drug delivery methods. The intended outcome is a novel set of polymeric gel systems, which can reversibly bind a wide variety of drugs (small molecules, nucleic acid based drugs, proteins), in which drug release is triggered by an electric potential and drug transport is controlled by means of sonophoresis. The main advantage of drug delivery via sonophoresis is elimination of risks associated with injections such as infection and damage to local tissue, and elimination of patient discomfort, pain and fear.Read moreRead less
Connecting man to machine: Wireless brain-machine interface. This project aims to enable direct wireless transmission of brain signals leading to reliable thought control of computers, wheelchairs, exoskeletons and vehicles. Such technology is currently limited by the fidelity, reliability, safety and longevity of the electrodes used to record signals from the brain. Partner organisation, SmartStent, has developed a novel stent-based electrode array which allows the extraction of high fidelity n ....Connecting man to machine: Wireless brain-machine interface. This project aims to enable direct wireless transmission of brain signals leading to reliable thought control of computers, wheelchairs, exoskeletons and vehicles. Such technology is currently limited by the fidelity, reliability, safety and longevity of the electrodes used to record signals from the brain. Partner organisation, SmartStent, has developed a novel stent-based electrode array which allows the extraction of high fidelity neural information without risky brain surgery and implant rejection. The project aims to combine SmartStent's stent-electrode technology with the diamond materials technology developed by the research team for hermetic encapsulation of electronics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101458
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Investigation and development of biological anti-adhesive coatings. Lubricin is a biological anti-adhesive protein that is found in mammalian joints. This project will investigate the properties and action of Lubricin and develop novel anti-adhesive coating technologies to eliminate problems associated with non-specific binding of biomolecules in microfluidic and biosensor applications.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775614
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
National Electromagnetic Characterization Facility for Advanced Electronic and Biomaterials. The proposed Material Characterisation Facility using non-destructive methods will be unique to Australia. Precise characterisation of advanced materials such as dielectrics and superconductors using the facility will progress emerging technologies within the electronic and communication research area. The inclusion of a microwave scanning test bed within the laboratory will allow engineers, scientists, ....National Electromagnetic Characterization Facility for Advanced Electronic and Biomaterials. The proposed Material Characterisation Facility using non-destructive methods will be unique to Australia. Precise characterisation of advanced materials such as dielectrics and superconductors using the facility will progress emerging technologies within the electronic and communication research area. The inclusion of a microwave scanning test bed within the laboratory will allow engineers, scientists, biologists and medical scientists to safely detect the intrinsic electromagnetic properties of electronic materials and tumours in biological tissues or poor quality agricultural produce. This comprehensive material characterisation facility will therefore benefit the peoples of Australasia in many significant and diverse ways.Read moreRead less
Atomic scale precision engineering of cell-material interfaces. This project aims to determine the molecular structure of the interface between novel peptide self-assemblies and cell membranes through x-ray diffraction and molecular simulation. The project will generate knowledge to enable atomic scale engineering of peptide nanomaterials, and exploitation of these materials to modulate cell responses. Expected outcomes include designed peptide nanostructures with specific chemical and physical ....Atomic scale precision engineering of cell-material interfaces. This project aims to determine the molecular structure of the interface between novel peptide self-assemblies and cell membranes through x-ray diffraction and molecular simulation. The project will generate knowledge to enable atomic scale engineering of peptide nanomaterials, and exploitation of these materials to modulate cell responses. Expected outcomes include designed peptide nanostructures with specific chemical and physical cues to promote sustainable growth of desired cells, whilst inhibiting undesirable responses. These outcomes should provide benefits in terms of a practical toolkit for tailoring structure and function of peptide nanostructures and open up a new era in molecular design of smart biomaterials. This easily scalable, new materials platform will contribute to emerging high-value manufacturing industries in Australia.Read moreRead less