A gold-coated magnetic nanoparticle biosensor for detecting microRNA. The project aims to develop a biosensor for detecting short sequences of RNA, called microRNA (miRNA) in blood. There are about 100 miRNA sequences that are involved in most biological processes. Changes in the levels of some miRNA sequences can serve as a biomarker for many diseases including cancers. The miRNA will be detected using gold-coated magnetic nanoparticles modified with DNA sequences complementary to the miRNA of ....A gold-coated magnetic nanoparticle biosensor for detecting microRNA. The project aims to develop a biosensor for detecting short sequences of RNA, called microRNA (miRNA) in blood. There are about 100 miRNA sequences that are involved in most biological processes. Changes in the levels of some miRNA sequences can serve as a biomarker for many diseases including cancers. The miRNA will be detected using gold-coated magnetic nanoparticles modified with DNA sequences complementary to the miRNA of interest to capture the miRNA. Application of a magnetic field allows the levels of miRNA to be detected electrochemically. The expected outcome is a commercialisable biosensor for miRNA both as a diagnostic early detection device and a prognostic device for a range of miRNA biomarkers.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC140100022
Funder
Australian Research Council
Funding Amount
$2,148,935.00
Summary
ARC Training Centre for Portable Analytical Separation Technologies. ARC Training Centre for Portable Analytical Separation Technologies. Portable analytical separation systems will enable point-of sample analysis for complex samples in food, environmental and clinical applications. The Training Centre aims to train the next generation of industry-ready Australian researchers through creating a sustainable research partnership between university-based researchers and Australian industry focused ....ARC Training Centre for Portable Analytical Separation Technologies. ARC Training Centre for Portable Analytical Separation Technologies. Portable analytical separation systems will enable point-of sample analysis for complex samples in food, environmental and clinical applications. The Training Centre aims to train the next generation of industry-ready Australian researchers through creating a sustainable research partnership between university-based researchers and Australian industry focused on developing new capabilities and technologies that have the potential to facilitate, support, or catalyse the progressive deployment of portable separation science technologies into society. This will enable the development of new, portable and affordable analytical separation systems and contribute to creating a sustainable, globally competitive manufacturing industry in Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100087
Funder
Australian Research Council
Funding Amount
$410,000.00
Summary
Advanced Macromolecular Materials Characterisation Facility (AMMCF). Advanced macromolecular materials characterisation facility: The facility will allow precise characterisation of (bio)macromolecular materials, from chemical structures and composition as a function of size or biodistribution, to film thickness in multi-layer materials, to material hydrophobicity and permeability. Novel information derived from these state-of-the-art instruments is highly valuable in understanding structure-pro ....Advanced Macromolecular Materials Characterisation Facility (AMMCF). Advanced macromolecular materials characterisation facility: The facility will allow precise characterisation of (bio)macromolecular materials, from chemical structures and composition as a function of size or biodistribution, to film thickness in multi-layer materials, to material hydrophobicity and permeability. Novel information derived from these state-of-the-art instruments is highly valuable in understanding structure-property relationships, which are crucial for the development of the next generation of advanced materials with applications in electronics, optics, sensors, membranes, nanocoatings, biomaterials and polymer therapeutics. This facility underpins the efforts of the participating institutes in increasing the quality and quantity of research outcomes.Read moreRead less
ARC Centre of Excellence in Quantum Biotechnology. ARC Centre of Excellence in Quantum Biotechnology. The ARC Centre of Excellence in Quantum Biotechnology aims to develop paradigm-shifting quantum technologies to observe biological processes and transform our understanding of life. It seeks to create technologies that go far beyond what is possible today, from portable brain imagers to super-fast single protein sensors, and to use them to unravel key problems including how enzymes catalyse reac ....ARC Centre of Excellence in Quantum Biotechnology. ARC Centre of Excellence in Quantum Biotechnology. The ARC Centre of Excellence in Quantum Biotechnology aims to develop paradigm-shifting quantum technologies to observe biological processes and transform our understanding of life. It seeks to create technologies that go far beyond what is possible today, from portable brain imagers to super-fast single protein sensors, and to use them to unravel key problems including how enzymes catalyse reactions and how higher brain function emerges from networks of neurons. By building a diverse, multidisciplinary, and industry-engaged ecosystem, the Centre means to develop our future leaders at the interface of quantum science and biology and drive Australian innovation across manufacturing, energy, agriculture, health, and national security.Read moreRead less
ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to unde ....ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to understand how single cells react to and communicate with their surroundings. This science will underpin a new generation of devices capable of probing the response of cells within individuals to environmental conditions or treatment, creating innovative and powerful new sensing platforms.Read moreRead less