Cell Membrane Coated Photonic Crystal to study Receptor-Ligand Interactions. The current gold-standard assays for examining receptor-ligand interactions require expensive and costly fluorescent or radioactive labels or proteomics processes. This project aims to develop Artificial Photonic Cells by directly coating photonic crystals with cell membranes. The Artificial Photonic Cells retain the protein receptors in their native cell membrane environment and allow for label-free monitoring of the r ....Cell Membrane Coated Photonic Crystal to study Receptor-Ligand Interactions. The current gold-standard assays for examining receptor-ligand interactions require expensive and costly fluorescent or radioactive labels or proteomics processes. This project aims to develop Artificial Photonic Cells by directly coating photonic crystals with cell membranes. The Artificial Photonic Cells retain the protein receptors in their native cell membrane environment and allow for label-free monitoring of the receptor-ligand interactions using inexpensive miniature spectrometers - radically transforming these assays. This would generate fundamental and applied knowledge of materials sciences, photonic, and biointerfaces for label-free, ultra-sensitive, and selective assays to enable future drug and diagnostics target discovery. Read moreRead less
Laser-free on-chip super-resolution microscopy. The project aims to develop a compact, cost-effective on-chip super-resolution microscope through an innovative combination of imaging algorithms, optics and integrated photonics. This project addresses limitations in imaging algorithms that increase laser system complexity and constrain imaging speed and applications, as well as nanostructure fabrication issues. Expected outcomes include the discovery of emitter self-interference microscopy, new k ....Laser-free on-chip super-resolution microscopy. The project aims to develop a compact, cost-effective on-chip super-resolution microscope through an innovative combination of imaging algorithms, optics and integrated photonics. This project addresses limitations in imaging algorithms that increase laser system complexity and constrain imaging speed and applications, as well as nanostructure fabrication issues. Expected outcomes include the discovery of emitter self-interference microscopy, new knowledge in imaging, photonics and biophysics, the world’s fastest super-resolution technology, compact on-chip nanoscopy that can be added to existing technology and proof of concept in three areas. Benefits are anticipated in commercialisation, improved photonics devices and usage in biophysics.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL210100180
Funder
Australian Research Council
Funding Amount
$2,781,000.00
Summary
Upconversion nanophotonic systems . The photon upconversion process can produce visible light from lower-energy near-infrared incident light. This Laureate Program aims to address major bottlenecks in upconversion nanotechnology – the efficiency, stability and absorption bandwidth. Expected outcomes include new knowledge in the interface design of hybrid materials, a world-leading single-particle spectroscopy system, a new family of molecular probes, and novel super-resolution microscopy for fun ....Upconversion nanophotonic systems . The photon upconversion process can produce visible light from lower-energy near-infrared incident light. This Laureate Program aims to address major bottlenecks in upconversion nanotechnology – the efficiency, stability and absorption bandwidth. Expected outcomes include new knowledge in the interface design of hybrid materials, a world-leading single-particle spectroscopy system, a new family of molecular probes, and novel super-resolution microscopy for functional imaging of subcellular organelles. This research offers exciting opportunities for single-molecule tracking, quantitative diagnostics, non-invasive imaging, bio-mechanical force measurement and thermometry; tools to observe the nanoscale world inside live cells.Read moreRead less
Milk protein profiling powered by multiplexed single molecule assay. This project aims to develop a novel device, comprising advanced single molecule imaging, microfluidics and immunoassay technologies, for quantification of milk protein variants. Milk quality is central to dairying and variants of proteins in milk affect its market value. No current milk protein detection technologies are readily applied in milk production quality control. This project aims to produce a device that can be used ....Milk protein profiling powered by multiplexed single molecule assay. This project aims to develop a novel device, comprising advanced single molecule imaging, microfluidics and immunoassay technologies, for quantification of milk protein variants. Milk quality is central to dairying and variants of proteins in milk affect its market value. No current milk protein detection technologies are readily applied in milk production quality control. This project aims to produce a device that can be used by milk producers and farms to profile protein variants with high sensitivity in a single test in an hour and screen unwanted protein contamination. The platform also has great potential for detecting other complex and low content analytes. It builds on innovations in nanoparticles and recent industry collaboration.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100070
Funder
Australian Research Council
Funding Amount
$368,446.00
Summary
Optical wavelength conversion in nonlinear dielectric nano-resonators. This project aims to uncover new opportunities to change the colour of light on the nanoscale, taking advantage of revolutionary advances in high-precision nano-fabrication. It will bring deeper understanding of the interaction between light and matter in dielectric resonators with sizes smaller than the visible light wavelength. This is expected to open a pathway for new telecommunication and microscopy-related technologies ....Optical wavelength conversion in nonlinear dielectric nano-resonators. This project aims to uncover new opportunities to change the colour of light on the nanoscale, taking advantage of revolutionary advances in high-precision nano-fabrication. It will bring deeper understanding of the interaction between light and matter in dielectric resonators with sizes smaller than the visible light wavelength. This is expected to open a pathway for new telecommunication and microscopy-related technologies and move towards increasing energy efficiency, scalability and security of optical communication networks of the future.Read moreRead less
All-on-chip twisted light modulator for ultrahigh-capacity data processing. The project aims to develop a conceptually new all-on-chip twisted light modulator via photonic integration of a customised twisted-light metasurface with on-chip optical waveguides. The goal is to replace current bulky, slow, and costly spatial light modulators by a compact nanophotonic chip for the generation and detection of multiple twisted-light modes. Project outcomes include new knowledge in photonic integration a ....All-on-chip twisted light modulator for ultrahigh-capacity data processing. The project aims to develop a conceptually new all-on-chip twisted light modulator via photonic integration of a customised twisted-light metasurface with on-chip optical waveguides. The goal is to replace current bulky, slow, and costly spatial light modulators by a compact nanophotonic chip for the generation and detection of multiple twisted-light modes. Project outcomes include new knowledge in photonic integration and 3D meta-optics, and novel nanophotonic devices for twisted light, which will expand applications of twisted light for all-on-chip fibre-optic communications and holographic displays. The ultra-compact, high-capacity, efficient twisted-light modulators are expected to have a practical impact on many photonic applications.Read moreRead less