Correlation between surface force and morphology of self-assembled monolayer. As a most potential solid support for biological molecules without denaturing their functions, gold thiol self-assembled monolayers (SAMs) have been studied extensively for surface fabrication. In this project we will prepare functional monolayers using newly synthesized thiol derivatives, evaluate correlation between surface force and surface morphology of the SAMs using the surface forces apparatus, and optimize the ....Correlation between surface force and morphology of self-assembled monolayer. As a most potential solid support for biological molecules without denaturing their functions, gold thiol self-assembled monolayers (SAMs) have been studied extensively for surface fabrication. In this project we will prepare functional monolayers using newly synthesized thiol derivatives, evaluate correlation between surface force and surface morphology of the SAMs using the surface forces apparatus, and optimize the condition to fabricate biological devices such as immune sensors.Read moreRead less
Combining the soft with the hard: The assembly of artificial cell membranes on porous semiconductors. The platform technologies developed in this project will have a wide range of applications. They will reveal new insights into drug-membrane and drug-protein interactions underpinning development of a new generation of drugs acting on transmembrane proteins that are linked to a wide range of diseases. The development of membrane-based biosensing devices targeting ion channels, membrane active pe ....Combining the soft with the hard: The assembly of artificial cell membranes on porous semiconductors. The platform technologies developed in this project will have a wide range of applications. They will reveal new insights into drug-membrane and drug-protein interactions underpinning development of a new generation of drugs acting on transmembrane proteins that are linked to a wide range of diseases. The development of membrane-based biosensing devices targeting ion channels, membrane active peptides or toxins which can be applied to biomedical diagnostics, biotoxin detection, environmental and food control will be readily achievable. This international interdisciplinary nanobiotechnology programme and its outcomes will enhance Australia's abilities in frontier technologies and build research strength in nanobiotechnology.Read moreRead less