Prevention Of Asthma In Young Children Via Immunostimulation
Funder
National Health and Medical Research Council
Funding Amount
$679,683.00
Summary
Persistent asthma is a major problem for Australia yet none of the current therapies do more that control the condition. The long-term solution is to prevent asthma from progressing to the persistent form. The major risk factors are: family history, early allergy and recurrent severe lower respiratory infections (sLRI) in the early life. We will conduct a randomized clinical trial to prevent sLRI using a novel bacterial-derived immunostimulant in infants at high risk of developing asthma.
Quadruple UltrA-low-dose TReamenT For HypErTension - QUARTET
Funder
National Health and Medical Research Council
Funding Amount
$1,242,865.00
Summary
High blood pressure is common and a major cause of heart disease and stroke. While many people with hypertension are on some treatment, in over half blood pressure targets are not reached and their high blood pressure is hence uncontrolled. In this research we investigate whether an approach that combines 4 types of blood pressure lowering medications at quarter doses into one pill, may be a more effective way of controlling blood pressure and doing this with few side effects.
General Practice Optimising Structured MOnitoring To Improve Clinical Outcomes In Type 2 Diabetes: GP-OSMOTIC T2D
Funder
National Health and Medical Research Council
Funding Amount
$864,980.00
Summary
We will study the use of a new technology, retrospective continuous glucose monitoring (r-CGM), to help achieve glucose targets for people with type 2 diabetes (T2D) in General Practice (GP). This is important because controlling glucose levels improves disease outcomes and because T2D is mostly managed in GP where the majority of people are out of glucose target levels and GPs and patients currently don’t have a simple effective method for monitoring blood glucose levels to guide treatment.
A Multi-centre Randomised Controlled Trial To Compare Nasal Balloon Autoinflation Versus No Nasal Balloon Autoinflation For Otitis Media With Effusion In Aboriginal And Torres Strait Islander Children (the INFLATE Trial)
Funder
National Health and Medical Research Council
Funding Amount
$2,534,580.00
Summary
Otitis media with effusion (OME) or ’glue ear’ is a common ear problem in Aboriginal and Torres Strait Islander children. In OME, fluid accumulates in the middle ear. This can cause hearing loss and learning difficulties and lead to surgery. We will see if the use of a simple device in which a child blows up a balloon with their nostrils (nasal balloon autoinflation) helps resolve glue ear, improves hearing and is acceptable for the management of this important ear health problem.
Determining Patterns Of Cessation And Relapse In A Cohort Of People Who Inject Drugs
Funder
National Health and Medical Research Council
Funding Amount
$1,189,791.00
Summary
Harms related to injecting drug use represent the bulk of the burden attributable to illicit drugs in Australia. In this study we will determine rates of long term cessation of injecting drug use, and relapse, and key drivers of these outcomes such as drug treatment or housing provision. Findings will inform policy and practice around injecting drug use in Australia over the coming decade.
Stepping Up To Insulin: A Cluster Randomised Trial Of Team-based Transition To Insulin In Primary Care For Patients With Poorly Controlled Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$796,751.00
Summary
Helping people control their diabetes through the best possible medical care is important. Most people with diabetes eventually need insulin yet this is a step in treatment that is often resisted by patients and GPs. This study will help GPs and Practice Nurses work with patients who have reached this stage make the change to insulin treatment in a safe, effective, convenient and timely way. This will have enormous benefits through reduced diabetes complications and improved quality of life.
Mechanisms Of Resistance To Immunological Targeting Of Primary And Metastatic Colorectal Cancers
Funder
National Health and Medical Research Council
Funding Amount
$612,828.00
Summary
The immune system influences the outcome in patients with cancer. We have been early adopters of immunotherapy approaches to target cancer cells using the novel approaches to enhance immune attack on cells that aberrantly express cancer regulators. These represent drivers to which cancer cells are addicted. A central tenant of optimizing immunotherapies has been to employ immune stimuli in concert with removing immune blocking systems. Our research plan is to improve immunotherapy efficiency.
Preventing Chronic Disease In Patients With Low Health Literacy Using E-health And Teamwork In Primary Health Care.
Funder
National Health and Medical Research Council
Funding Amount
$1,264,893.00
Summary
This study will evaluate whether an innovative intervention tailored to patients’ health literacy improves preventive care for vulnerable and disadvantaged patients in general practice. It will use e-health to support practice nurses to reduce their patients’ risk of chronic disease.
A Randomised Trial Of A Clinical Prediction Tool For Targeting Depression Care (Target-D)
Funder
National Health and Medical Research Council
Funding Amount
$944,774.00
Summary
The Target-D Study uses a novel clinical prediction tool to test a new approach to depression care in general practice based upon sub-grouping patients into low, medium and high risk of ongoing depression. Participants will be randomly allocated to targeted treatments based upon their risk profile or to usual general practice care. We will measure whether the new approach results in greater improvements in depressive symptoms, quality of life and functioning and whether there are cost benefits.
The CRISP Trial: An RCT Of Risk Assessment And Decision Support To Implement Risk-stratified Colorectal Cancer Screening In Primary Care.
Funder
National Health and Medical Research Council
Funding Amount
$936,641.00
Summary
There is a mismatch between people’s use of bowel cancer screening tests through faecal occult blood testing or colonoscopy and their individual risk of bowel cancer. Building on the work of our NHMRC Centre for Research Excellence (CRE) on Optimising Colorectal Cancer Screening, this trial will test the effect of an electronic risk assessment tool, implemented in general practice, on use of the most appropriate screening test for bowel cancer based on a person’s risk of developing the condition