A New Direction For TB Control In Highly Endemic Countries: A RCT Of Active Case Finding
Funder
National Health and Medical Research Council
Funding Amount
$1,362,910.00
Summary
Tuberculosis is the number 1 health problem in Vietnam . Many people with TB do not know they have the disease but are infectious to others. Hence, the disease continues to spread. This project will investigate the role of x-ray screening to detect and treat more people with TB, particularly those who do not have symptoms. This may be an important element of future TB control programs in Vietnam and elsewhere in our region.
The HIV Prevention Revolution: Measuring Outcomes And Maximising Effectiveness
Funder
National Health and Medical Research Council
Funding Amount
$1,081,723.00
Summary
There have been extra-ordinary recent biomedical advances in HIV prevention. These present an opportunity to turn the HIV epidemic around. We will undertake implementation research to optimise the impact of the new tools at the population level. NSW has a detailed HIV strategy with explicit targets for reduction of HIV transmission over the period 2012 to 2020. Our research will guide optimum program delivery to drive new HIV infections down in Australia and other high income settings.
A Randomized Clinical Trial Comparing Effectiveness Of 4RIF And 9INH For Treatment Of Latent TB Infection
Funder
National Health and Medical Research Council
Funding Amount
$496,875.00
Summary
Treatment of latent tuberculosis infection (LTBI) is one intervention that is known to prevent the occurrence of active TB. Current treatment is based on a six to nine month course of isoniazid. The treatment has side effects in some people and many people do not complete the treatment. The present study is to test an alternative treatment regimen (4 months of rifampicin) which has fewer side-effects and is more likely to be completed.
Long term economic impacts of disease on older workers to 2030: Costs to government and individuals and opportunities for intervention. This project will fill substantial gaps in Australian evidence about the health conditions of the future that will keep older workers out of the labour market and diminish their own immediate and long-term livings standards, thereby reducing funds available to government. We will address one of the most significant issues resulting from the fundamental changes t ....Long term economic impacts of disease on older workers to 2030: Costs to government and individuals and opportunities for intervention. This project will fill substantial gaps in Australian evidence about the health conditions of the future that will keep older workers out of the labour market and diminish their own immediate and long-term livings standards, thereby reducing funds available to government. We will address one of the most significant issues resulting from the fundamental changes to the demography of the Australian labour market and one that is regularly raised by the government following the release of the 2002 and 2007 Intergenerational Reports. This project will also examine the interventions that would improve the health of older workers and increase labour force participation over the long term.Read moreRead less
Can parents teach their children to drink alcohol responsibly? Or, is one drop a drop too many? Parents typically supply alcohol to their children believing it is the best way to teach responsible drinking. Whether parents should provide alcohol is controversial and the evidence to inform this decision is unclear. This research will provide an in-depth understanding of the consequences of parents providing alcohol to their children and when, where and how this can be done to minimise harm. This ....Can parents teach their children to drink alcohol responsibly? Or, is one drop a drop too many? Parents typically supply alcohol to their children believing it is the best way to teach responsible drinking. Whether parents should provide alcohol is controversial and the evidence to inform this decision is unclear. This research will provide an in-depth understanding of the consequences of parents providing alcohol to their children and when, where and how this can be done to minimise harm. This is a national priority as alcohol abuse is a leading cause of injury and death among young Australians and developing the knowledge for preventive health care is essential. This research will provide parents with the information they need to give their children a healthier start to life.Read moreRead less
Can and should we link data at a national level? Vaccine safety surveillance: A case study. This project provides many benefits for the community, exploring the legal and ethical issues around consent for data linkage, convening Citizens' Juries to weigh the evidence and make recommendations. It addresses National Research Priorities: Promoting and Maintaining Good Health and Safeguarding Australia as well as National Collaborative Research Infrastructure Strategy priorities. It uses vaccine sa ....Can and should we link data at a national level? Vaccine safety surveillance: A case study. This project provides many benefits for the community, exploring the legal and ethical issues around consent for data linkage, convening Citizens' Juries to weigh the evidence and make recommendations. It addresses National Research Priorities: Promoting and Maintaining Good Health and Safeguarding Australia as well as National Collaborative Research Infrastructure Strategy priorities. It uses vaccine safety surveillance as a case study to evaluate the effectiveness of data linkage (through linking Commonwealth immunisation data to state hospital data) and the methodologies and lessons learnt from cross jurisdictional data linkage can be transferred to other areas. Read moreRead less
Multi-dimensional Temporal Abstraction to Support Neonatal Clinical Research. Each year, the death of a baby causes grief for thousands of Australian parents, contributes to depression and considerable anxiety in the population. In this work we propose procedures that will significantly reduce this unhappy scenario. The availability of a complex trend and pattern analysis will give Neonatologists access to predictive clinical analysis that has not previously been available locally or internation ....Multi-dimensional Temporal Abstraction to Support Neonatal Clinical Research. Each year, the death of a baby causes grief for thousands of Australian parents, contributes to depression and considerable anxiety in the population. In this work we propose procedures that will significantly reduce this unhappy scenario. The availability of a complex trend and pattern analysis will give Neonatologists access to predictive clinical analysis that has not previously been available locally or internationally. Thus, significant benefits in terms of lower mortality rates and lower long-term disability rates among babies requiring special care is possible. This research will provide the basis for future projects that will support regional hospitals.Read moreRead less
Planning female and male vaccination and cervical screening strategies to achieve optimal prevention of HPV-related disease. The findings from this research will inform the development of public health policy on the most cost-effective utilisation of resources for preventing cervical, anogenital and head/neck cancers, and genital warts, in women and men, due to human papillomavirus (HPV). We will evaluate strategies for using emerging screening and vaccine technologies to prevent HPV-related dis ....Planning female and male vaccination and cervical screening strategies to achieve optimal prevention of HPV-related disease. The findings from this research will inform the development of public health policy on the most cost-effective utilisation of resources for preventing cervical, anogenital and head/neck cancers, and genital warts, in women and men, due to human papillomavirus (HPV). We will evaluate strategies for using emerging screening and vaccine technologies to prevent HPV-related disease, and assess potential adverse outcomes of vaccination. Men are currently not covered by routine vaccination or screening programs; this research will assess the benefit to men of vaccinating women only, and will consider the impact of vaccination and other interventions targeted towards men.Read moreRead less
After the questions: outcomes of routine screening for domestic violence in NSW Health services. Recent research indicates that domestic violence is the leading contributor to death, disability and illness in women aged 15-44 in Australia and leads to health costs of $314 m annually (VicHealth 2004, Access Economics 2004). Routine screening is a low cost measure aimed at prevention and early intervention for domestic violence, which has been successfully introduced for women entering antenatal, ....After the questions: outcomes of routine screening for domestic violence in NSW Health services. Recent research indicates that domestic violence is the leading contributor to death, disability and illness in women aged 15-44 in Australia and leads to health costs of $314 m annually (VicHealth 2004, Access Economics 2004). Routine screening is a low cost measure aimed at prevention and early intervention for domestic violence, which has been successfully introduced for women entering antenatal, early childhood, mental health and drug and alcohol services operated by NSW Health. The research will be the first study of its size to consider the outcomes of routine screening for domestic violence in public health settings in the Australian context.Read moreRead less
Fear, sadness and alcohol in adolescence: A test of innovative curriculum models to prevent adverse outcomes. Lack of mastery over fear, sadness and alcohol use are risk factors for the common forms of mental ill health. When fully developed, anxiety, depressive and substance use disorders account for three quarters of the disability attributed to mental disorders. While prevention strategies exist, none are universally feasible. Climate schools represents a utility that is acceptable, fits with ....Fear, sadness and alcohol in adolescence: A test of innovative curriculum models to prevent adverse outcomes. Lack of mastery over fear, sadness and alcohol use are risk factors for the common forms of mental ill health. When fully developed, anxiety, depressive and substance use disorders account for three quarters of the disability attributed to mental disorders. While prevention strategies exist, none are universally feasible. Climate schools represents a utility that is acceptable, fits within the school syllabus, is effective, and is scaleable to meet the needs of all schools in Australia. If it reduces the target risk factors by 10-20%, a minimal estimate based on the pilot work, then it will be a most cost effective contribution to promoting and maintaining the good health of the community.
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