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Discovery Early Career Researcher Award - Grant ID: DE120102878
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Mobile phone text reminders to modify behaviours and prevent cardiovascular disease. Strategies are needed to improve adherence to behavioural and medical preventative treatments for heart disease. Brief informative reminders sent via mobile phone text message have potential as a cheap and safe method of improving behavioural change and adherence to treatments in people at risk of cardiovascular disease.
Binary regression with additive predictors: new statistical theory with healthcare applications. This project will develop new statistical analysis techniques for predicting whether someone is at risk of adverse health outcomes. The project will then apply the new techniques to a large database on heart attacks, leading to new insights into how patient characteristics and treatments affect the chance of dying from a heart attack.
Electrochemical biosensors for detection of cardiac disease markers in blood. Cardiovascular diseases leading to heart failure have a prevalence of over 16 per cent in Australia. The social, economic and health burden is higher than for any other disease group. Hence, it is critically important to develop fit-for-purpose sensors of known cardiac biomarkers, which alert patients and clinicians of the risk of imminent heart failure.
Discovery And Translation Of Evidence For New Strategies To Combat Cardiovascular Diseases
Funder
National Health and Medical Research Council
Funding Amount
$17,802,750.00
Summary
The Program brings together clinicians, epidemiologists and statisticians in a unique endeavour combating heart attack and stroke as well as diabetes and kidney disease, all of which are closely related, through “hardening of the arteries”. The Program will provide fresh evidence on innovative strategies for treating and preventing these disorders, as well as strategies for translating them into more effective health policy and improved clinical practice.
The RINSE Trial: The Rapid Infusion Of Cold Normal SalinE By Paramedics During CPR
Funder
National Health and Medical Research Council
Funding Amount
$708,241.00
Summary
Sudden cardiac arrest is a common event in the community. Therapeutic hypothermia decreases the brain injury caused by the cardiac arrest and is currently used in the hospital after successful resuscitation. However, there may be better outcomes if the brain is cooled by paramedics during resuscitation. We will compare survival rates for those patients cooled early by paramedics using an infusion of ice-saline during cardiac arrest with those patients who are later cooled by the hospital.
Cardiovascular diseases and heart failure rates are increasing worldwide. This is largely a result of the heart’s limited capacity for self-repair. Stem cells now provide an exciting potential novel therapy. We have recently demonstrated the feasibility of this therapy in a preclinical model of heart attack. Nevertheless, further work is required before human clinical trials can take place. This project will dismantle barriers preventing progression to these clinical trials.
Atrial Remodelling And Risk Of Arrhythmias In Endurance Athletes
Funder
National Health and Medical Research Council
Funding Amount
$1,006,750.00
Summary
Atrial fibrillation (AF) is a heart rhythm problem that is 3 to 5 times more common in male athletes than the general male population - the reasons for this excess are not known. We hypothesize that the cardiac enlargement that is caused by high intensity exercise training increases the risk of AF. We will assess heart structure and function in 420 athletes across the age spectrum and assess the degree to which sports-induced changes are permanent and whether this represents an AF risk.
Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest: A Phase III Multi-Centre Randomised Controlled Trial (The TAME Cardiac Arrest Trial)
Funder
National Health and Medical Research Council
Funding Amount
$2,069,878.00
Summary
The TAME Cardiac Arrest trial will study the ability of higher carbon dioxide (CO2) levels to reduce brain damage, comparing giving patients ‘normal’ to ‘slightly higher than normal’ blood CO2 levels and assessing their ability to return to normal life-tasks. It will be the largest trial ever conducted in heart attack patients in the ICU. This therapy is cost free and, if shown to be effective, will improve thousands of Australian lives, transform clinical practice, and yield major savings.