Development of an Attenuated Infectious Laryngotracheitis Virus Vaccine. This project will develop novel methods for identification of genes involved in virulence of the important avian pathogen Infectious Laryngotracheitis Virus and produce an attenuated, antigenically marked infectious laryngotracheitis virus vaccine strain by specific disruption and deletion of two or more genes in the virusÕs genome.
Infectious laryngotracheitis is a major disease of chickens throughout the world, but curre ....Development of an Attenuated Infectious Laryngotracheitis Virus Vaccine. This project will develop novel methods for identification of genes involved in virulence of the important avian pathogen Infectious Laryngotracheitis Virus and produce an attenuated, antigenically marked infectious laryngotracheitis virus vaccine strain by specific disruption and deletion of two or more genes in the virusÕs genome.
Infectious laryngotracheitis is a major disease of chickens throughout the world, but current vaccines retain some capacity to cause disease. The development of novel attenuated vaccines will thus enhance control of this important disease of poultry.Read moreRead less
A comprehensive analysis of the outer membrane, surface exposed and secreted proteome of Pasteurella multocida. Pasteurella multocida is the causative agent of a range of animal diseases. The molecular mechanisms of P. multocida pathogenesis are poorly understood and the current vaccines generally ineffective. We will identify all P. multocida outer membrane, surface exposed and secreted proteins expressed during natural infection, or under conditions which mimic natural infection, by a global p ....A comprehensive analysis of the outer membrane, surface exposed and secreted proteome of Pasteurella multocida. Pasteurella multocida is the causative agent of a range of animal diseases. The molecular mechanisms of P. multocida pathogenesis are poorly understood and the current vaccines generally ineffective. We will identify all P. multocida outer membrane, surface exposed and secreted proteins expressed during natural infection, or under conditions which mimic natural infection, by a global proteomics approach. We believe that secreted proteins and those found on the outer surface of the bacterial cell are likely to be crucial virulence determinants. The expected outcomes are the identification of a number of candidate vaccine antigens and an enhanced understanding of Pasteurella pathogenesis.Read moreRead less