A Randomized Clinical Trial Comparing Effectiveness Of 4RIF And 9INH For Treatment Of Latent TB Infection
Funder
National Health and Medical Research Council
Funding Amount
$496,875.00
Summary
Treatment of latent tuberculosis infection (LTBI) is one intervention that is known to prevent the occurrence of active TB. Current treatment is based on a six to nine month course of isoniazid. The treatment has side effects in some people and many people do not complete the treatment. The present study is to test an alternative treatment regimen (4 months of rifampicin) which has fewer side-effects and is more likely to be completed.
A New Direction For TB Control In Highly Endemic Countries: A RCT Of Active Case Finding
Funder
National Health and Medical Research Council
Funding Amount
$1,362,910.00
Summary
Tuberculosis is the number 1 health problem in Vietnam . Many people with TB do not know they have the disease but are infectious to others. Hence, the disease continues to spread. This project will investigate the role of x-ray screening to detect and treat more people with TB, particularly those who do not have symptoms. This may be an important element of future TB control programs in Vietnam and elsewhere in our region.
Discovery Early Career Researcher Award - Grant ID: DE240100168
Funder
Australian Research Council
Funding Amount
$413,847.00
Summary
Self-Supervised Sequential Biomedical Image-Omics. This project aims to develop a self-supervised sequential biomedical image-omics model to uncover the underlying biological processes e.g., normal or abnormal. Sequential biomedical images are state-of-the-art imaging modalities which allow to depict changes in progression to the human body. New self-supervised machine learning algorithms are proposed to derive features from heterogenous and unlabelled sequential images. These derived features w ....Self-Supervised Sequential Biomedical Image-Omics. This project aims to develop a self-supervised sequential biomedical image-omics model to uncover the underlying biological processes e.g., normal or abnormal. Sequential biomedical images are state-of-the-art imaging modalities which allow to depict changes in progression to the human body. New self-supervised machine learning algorithms are proposed to derive features from heterogenous and unlabelled sequential images. These derived features will then be used to characterise the morphological and functional changes, which provide opportunities to increase understanding of progression of diseases of individual subject. The outcome from this project will provide new insights into system biology with potential future benefits in healthcare.Read moreRead less
A formal foundation for security architecture. Security of computer systems is essential for the maintenance of privacy, confidentiality and integrity of personal, commercial and government data, and the trustworthiness of the computational devices that are embedded in critical societal infrastructure. However, current theoretical understanding of secure systems development is poor. The project will develop our understanding of an emerging approach to the design of secure systems and develop ver ....A formal foundation for security architecture. Security of computer systems is essential for the maintenance of privacy, confidentiality and integrity of personal, commercial and government data, and the trustworthiness of the computational devices that are embedded in critical societal infrastructure. However, current theoretical understanding of secure systems development is poor. The project will develop our understanding of an emerging approach to the design of secure systems and develop verification methods that may be applied to guarantee systems security. Its outcomes will contribute to processes for certifying systems at very high levels of security, a requirement in defence and government settings that will become increasingly significant in the commercial sector.Read moreRead less
Optimising Heart Disease Prevention And Management
Funder
National Health and Medical Research Council
Funding Amount
$4,647,175.00
Summary
As we become older and risk factors such as obesity become more common, our biggest contributor to death and disability, cardiovascular disease (including heart disease), will continue to exert an enormous burden on our health care system and society. We will extend our ground-breaking research on multidisciplinary teams to create new and innovative health care programs to optimise the prevention and management of new heart disease and chronic forms of heart disease.
Implementing Feferman-Landin Logic. The objective of this project is to utilise computer based verification tools (such as PVS and Rewritting Logic) to develop a software engineering environment for specifying and verifying systems written in high-level programming languages such as Java, Scheme, and ML. The project will thus subtantially advance the use of formal computer based tools to develop reliable programs and specifications for life-critical systems. The project will also develop form ....Implementing Feferman-Landin Logic. The objective of this project is to utilise computer based verification tools (such as PVS and Rewritting Logic) to develop a software engineering environment for specifying and verifying systems written in high-level programming languages such as Java, Scheme, and ML. The project will thus subtantially advance the use of formal computer based tools to develop reliable programs and specifications for life-critical systems. The project will also develop formally
based interoperability between the PVS and Maude systems, two widely
used computer tools for reasoning about complex systems.Read moreRead less
The Management To Optimise Diabetes And MEtabolic Syndrome Risk Reduction Via Nurse-led Intervention (MODERN) Study
Funder
National Health and Medical Research Council
Funding Amount
$1,445,861.00
Summary
There is increasing recognition of society’s responsibility to provide effective and sustainable health care to the entire population and not just selected parts. This practical study will test the impact of a nurse-led, multidisciplinary prevention program to reduce the risk of future cardiovascular events in middle-aged individuals at a high risk of developing cardiovascular disease (CVD) living in regional Australia.
Supporting dynamic multidimensional entrepreneurial resilience in Australia. This project aims to model entrepreneurial resilience, its formation and its influence on how creative transformation occurs, and whether ex ante adaptive capacity is in turn enhanced by having mastered crises. The project proposes a theoretical model to holistically measure resilience across the life course. Using longitudinal data for self-employed individuals in Australia the project analyses the impact of crisis and ....Supporting dynamic multidimensional entrepreneurial resilience in Australia. This project aims to model entrepreneurial resilience, its formation and its influence on how creative transformation occurs, and whether ex ante adaptive capacity is in turn enhanced by having mastered crises. The project proposes a theoretical model to holistically measure resilience across the life course. Using longitudinal data for self-employed individuals in Australia the project analyses the impact of crisis and economic policy on entrepreneur’s behaviour and SMEs entry exit decisions. The project informs policy making through employing discrete choice experiments to elicit entrepreneur’s preferences for government policy and support post crisis. Read moreRead less
Preventing Falls In Older Aboriginal People: The Ironbark Trial
Funder
National Health and Medical Research Council
Funding Amount
$3,026,699.00
Summary
Australia’s Aboriginal and Torres Strait Islander population is ageing: in 1991, Aboriginal people aged 55 years and over accounted for only 6% of Australia’s total Aboriginal population and this proportion is predicted to double to 12% by 2021, with resulting increased in ageing conditions such as falls. This large scale trial in NSW, SA and WA will test the effectiveness of a community based program in reducing falls and improving function in older Aboriginal people.
Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to de ....Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to develop services and interventions aimed at preventing young people from becoming enmeshed in the criminal justice system.Read moreRead less