Exploiting Messenger RNA Export As A Novel Therapeutic Strategy To Treat Cancer
Funder
National Health and Medical Research Council
Funding Amount
$948,098.00
Summary
Novel therapies for cancers represent an area of unmet clinical need. We have identified a new biological pathway implicated in cancer, namely selective mRNA export. Compounds inhibiting other steps of the gene expression pathway are promising therapeutic candidates for cancer, yet mRNA export inhibitors do not exist. We propose to develop first-in-class inhibitors of mRNA export that selectively target transcriptionally addicted cancers with dysregulated RNA processing.
BETTER MAN Project: Tailored Early Online Intervention For Men Using Intimate Partner Violence
Funder
National Health and Medical Research Council
Funding Amount
$506,202.00
Summary
Domestic violence damages the health of families, particularly women and children. We aim to make all families safer by generating new knowledge from a world-first trial of a healthy relationship website (BETTER MAN). This website assists men to identify their use of abuse and violence early and motivate them to seek help. We will tailor their help-seeking response to their individual experiences. We will have the safety, health, and well-being of women and children as our focus in this work.
User-centred Design Of A Technology-mediated, Theory Driven, Intervention Package To Reduce Incorrect Use Of Child Car Restraints
Funder
National Health and Medical Research Council
Funding Amount
$691,342.00
Summary
This project aims to develop and optimise an efficient, cost-effective intervention that provides instruction on how to correctly use child car restraints, as well as promoting behaviours required to achieve correct restraint of children in cars. This work offers potential paradigm shifting solutions to a long-standing problem that is currently putting more than 50% of children travelling in cars at a three-fold increased risk of serious injury and death
Evidence For Action On Cold, Damp And Mould In Australian Homes
Funder
National Health and Medical Research Council
Funding Amount
$955,649.00
Summary
We know that living in cold and damp homes is bad for people's health. Surprisingly in Australia we do not know how much exposure to poor conditions and financial hardship combines to generate poor health at the population level. We will quantify this impact and estimate the benefit of interventions (such as mould removal and assistance for paying utility bills). This project will provide governments with evidence for tackling this housing-related health problem.