Discovery Early Career Researcher Award - Grant ID: DE230101466
Funder
Australian Research Council
Funding Amount
$442,723.00
Summary
Violent offenders in the night-time economy: Building the evidence. Alcohol-related violence in entertainment precincts is a significant community safety problem. This project aims to improve knowledge on individuals that are violent in entertainment precincts. It is expected to be the first study globally to use linked data to develop multi-system informed offending trajectories of violent offenders in these settings, examine the impact of patrons bans on offending trajectories, and apply situa ....Violent offenders in the night-time economy: Building the evidence. Alcohol-related violence in entertainment precincts is a significant community safety problem. This project aims to improve knowledge on individuals that are violent in entertainment precincts. It is expected to be the first study globally to use linked data to develop multi-system informed offending trajectories of violent offenders in these settings, examine the impact of patrons bans on offending trajectories, and apply situational action theory to alcohol-related violence. Results are expected to inform a critical knowledge gap and assist in the development of targeted violence preventive responses which reduce harm and make communities safer.Read moreRead less
Identification Of The Mechanisms Of Hepatic Fibrogenesis Aid In The Detection And Prediction Of Clinical Outcomes In Paediatric Cholestatic Liver Disease.
Funder
National Health and Medical Research Council
Funding Amount
$624,429.00
Summary
Biliary Atresia (BA) and Cystic Fibrosis Liver Disease (CFLD) are important causes of childhood cirrhosis. Diagnosis is difficult, treatments problematic, and outcomes suboptimal. In BA, bile duct obstruction in infants rapidly progresses to liver failure. It is the most common indication for liver transplantation in children. CFLD causes significant morbidity/mortality in about 20% of CF children. This proposal investigates the mechanisms of liver fibrosis (scarring) and the role of fibrosis in ....Biliary Atresia (BA) and Cystic Fibrosis Liver Disease (CFLD) are important causes of childhood cirrhosis. Diagnosis is difficult, treatments problematic, and outcomes suboptimal. In BA, bile duct obstruction in infants rapidly progresses to liver failure. It is the most common indication for liver transplantation in children. CFLD causes significant morbidity/mortality in about 20% of CF children. This proposal investigates the mechanisms of liver fibrosis (scarring) and the role of fibrosis in both diagnosis and predicting clinical outcome.Read moreRead less
HLA-G/H2-Bl Is Critical For Regulating Inflammation In The Liver
Funder
National Health and Medical Research Council
Funding Amount
$494,050.00
Summary
The key factor to induction of liver fibrosis, progression to cirrhosis, and hepatocellular carcinoma is inflammation. Liver transplant and liver regeneration following liver resection are also dramatically impaired by elevation of inflammation. We have identified a potent anti-inflammatory protein, HLA-G, that is critical for regulating post-surgical inflammation in the liver. We will determine if HLA-G can reverse and/or block liver fibrosis and modify HLA-G for improved clinical potential.
Discovery Early Career Researcher Award - Grant ID: DE200100359
Funder
Australian Research Council
Funding Amount
$420,960.00
Summary
Preventing crime in public spaces: everyday guardianship & territoriality . Safe public spaces are the cornerstone of liveable cities. Everyday users of public spaces are vital crime prevention guardians because they are frequently present in the absence of formal regulators like police. This project will investigate factors that enhance active guardianship and facilitate crime prevention in public spaces. It aims to generate new knowledge on the extent to which everyday users of public spaces d ....Preventing crime in public spaces: everyday guardianship & territoriality . Safe public spaces are the cornerstone of liveable cities. Everyday users of public spaces are vital crime prevention guardians because they are frequently present in the absence of formal regulators like police. This project will investigate factors that enhance active guardianship and facilitate crime prevention in public spaces. It aims to generate new knowledge on the extent to which everyday users of public spaces develop a sense of territorial control leading to conscious monitoring of public spaces and intervention in social problems. The project aims to inform crime prevention strategies that facilitate active guardianship leading to less crime, reduced fear of crime and enhanced opportunities for pro-social use of public spaces. Read moreRead less
Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to de ....Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to develop services and interventions aimed at preventing young people from becoming enmeshed in the criminal justice system.Read moreRead less
Understanding the emerging threat of conspiracy-fuelled extremism. This project aims to address the emerging threat of conspiracy-fuelled extremism in Australia. The project expects to produce new knowledge by identifying the unique factors driving this new form of extremism and the social harm it causes. Through three studies, the project will test a new theoretical model of conspiracy-fuelled extremism, will explore the threats and social harms this form of extremism creates, and will develop ....Understanding the emerging threat of conspiracy-fuelled extremism. This project aims to address the emerging threat of conspiracy-fuelled extremism in Australia. The project expects to produce new knowledge by identifying the unique factors driving this new form of extremism and the social harm it causes. Through three studies, the project will test a new theoretical model of conspiracy-fuelled extremism, will explore the threats and social harms this form of extremism creates, and will develop evidence-based insights into how it can be mitigated. The research should produce benefits for Australia by providing policymakers with a risk-assessment tool to identify individuals most 'at-risk' of violent extremism, and by providing knowledge about the services families may require to de-radicalise loved ones.Read moreRead less
Preventing terrorism through community-based approaches. This project aims to investigate the prevention of terrorism. It will examine approaches that involve police community engagement and local responses to violent extremism. This is a significant issue given communities are a key line of defence against terrorism. Expecting to generate new knowledge about counter-terrorism by examining policies adopted in Australia and abroad, the project will identify models of best practice for the prevent ....Preventing terrorism through community-based approaches. This project aims to investigate the prevention of terrorism. It will examine approaches that involve police community engagement and local responses to violent extremism. This is a significant issue given communities are a key line of defence against terrorism. Expecting to generate new knowledge about counter-terrorism by examining policies adopted in Australia and abroad, the project will identify models of best practice for the prevention of terrorism, ascertaining how community partnerships against terrorism can be improved. This will provide significant benefits by assisting police, government agencies, community groups and local service providers to implement and evaluate strategies that prevent terrorism.Read moreRead less
Role Of Tissue Ferritin As A Proinflammatory Mediator Of Hepatic Stellate Cell Activation In Hepatic Iron Overload.
Funder
National Health and Medical Research Council
Funding Amount
$574,890.00
Summary
The hepatic stellate cell is responsible for liver scarring (fibrosis) in chronic liver diseases such as the iron overload condition Haemochromatosis. Our research has identified a role for tissue-derived ferritin as a proinflammatory cytokine in hepatic stellate cell biology. This proposal will examine the mechanisms associated with ferritin's proinflammatory action and assess its role in the fibrosis which occurs in Haemochromatosis.
Lifting the burden of imprisonment: Creating safer and stronger communities. This project aims to identify how a reduction in imprisonment rates could benefit Australian communities and enhance their safety and wellbeing. It will link a range of statistical data sources on imprisonment, crime and community wellbeing. We will, for the first time, comprehensively demonstrate the impact of imprisonment on individuals and communities in Australia and beyond. Expected outcomes of this project include ....Lifting the burden of imprisonment: Creating safer and stronger communities. This project aims to identify how a reduction in imprisonment rates could benefit Australian communities and enhance their safety and wellbeing. It will link a range of statistical data sources on imprisonment, crime and community wellbeing. We will, for the first time, comprehensively demonstrate the impact of imprisonment on individuals and communities in Australia and beyond. Expected outcomes of this project include expansion and innovation of coercive mobility theory, novel integration of data, and a forecasting tool to assess the impact of imprisonment reduction on communities. This evidence will assist advocacy groups and policy makers seeking to address Australia’s burgeoning imprisonment rate.Read moreRead less
Identifying novel, health-related predictors of recidivism: Informing evidence-based throughcare. Throughcare is a policy priority for correctional authorities in Australia, however the evidence base to inform policy is limited. Using innovative modelling techniques and unique data from a large, representative cohort of ex-prisoners in Queensland, this study will: identify novel, health-related predictors of recidivism in the first two years after release from adult custody; examine the extent t ....Identifying novel, health-related predictors of recidivism: Informing evidence-based throughcare. Throughcare is a policy priority for correctional authorities in Australia, however the evidence base to inform policy is limited. Using innovative modelling techniques and unique data from a large, representative cohort of ex-prisoners in Queensland, this study will: identify novel, health-related predictors of recidivism in the first two years after release from adult custody; examine the extent to which risk and protective factors for recidivism vary over time and according to individual characteristics; and, provide evidence-based recommendations to improve throughcare interventions and reduce recidivism.Read moreRead less