Targeting the host lipid environment to disrupt malaria transmission. This project aims to characterise host molecules (in particular lipids) that are crucial for the transition of malaria parasites from one host to another. Malaria parasites encounter different environments upon their transition from human to the mosquito host. This project expects to generate new knowledge on physiological changes that are triggered by particular differences in micronutrient abundance that allow the parasites ....Targeting the host lipid environment to disrupt malaria transmission. This project aims to characterise host molecules (in particular lipids) that are crucial for the transition of malaria parasites from one host to another. Malaria parasites encounter different environments upon their transition from human to the mosquito host. This project expects to generate new knowledge on physiological changes that are triggered by particular differences in micronutrient abundance that allow the parasites to survive in the new host. Anticipated outcomes include the identification of new intervention strategies and improved transmission model systems for vector-borne diseases. This gained knowledge could provide benefits to future biomedical applications by informing diagnostics or treatment of lipid associated diseases.Read moreRead less
About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock a ....About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock and its role in the normal biology of the heart. New data will significantly enhance our understanding of the biology of MR and cortisol for the circadian time keeping function in peripheral tissues, and gain a clearer understand how our heart cells adapt to environmental circadian disruptors such as shift work. Read moreRead less
Why certain viruses don't get along in mosquitoes. The molecular mechanism. The overall goal of this project is to obtain an understanding of how certain insect-only viruses make mosquitoes incapable of transmitting diseases. These viruses, called insect-specific flaviviruses, can be employed as biocontrol agents for mosquito-borne human and veterinary diseases. However as it is currently unknown how exactly they affect mosquitoes, the safety and efficacy of their use can't be predicted. The pro ....Why certain viruses don't get along in mosquitoes. The molecular mechanism. The overall goal of this project is to obtain an understanding of how certain insect-only viruses make mosquitoes incapable of transmitting diseases. These viruses, called insect-specific flaviviruses, can be employed as biocontrol agents for mosquito-borne human and veterinary diseases. However as it is currently unknown how exactly they affect mosquitoes, the safety and efficacy of their use can't be predicted. The proposed project will dissect the very intricate mechanisms of interactions between insect-specific flaviviruses and mosquitoes and explain how exactly they prevent disease transmission. It should generate novel fundamental knowledge, implement innovative methodologies and provide training for students and junior scientist. Read moreRead less
Novel mechanisms by which retinal microglia regulate vascular development. This project aims to investigate how immune cells called microglia refine the developing retinal vasculature. New knowledge utilizing state of art imaging techniques is likely to be examine a completely novel mechanism by which vascular development occurs. This information is critical for enhancing our understanding of the role of immune cells in the nervous system and will guide the development of new ways of examining t ....Novel mechanisms by which retinal microglia regulate vascular development. This project aims to investigate how immune cells called microglia refine the developing retinal vasculature. New knowledge utilizing state of art imaging techniques is likely to be examine a completely novel mechanism by which vascular development occurs. This information is critical for enhancing our understanding of the role of immune cells in the nervous system and will guide the development of new ways of examining these cells. Expected outcomes include a novel way for assessing microglia in the developing nervous system and new knowledge. In the longer term the information gained in this project may be helpful for understanding scenarios where blood vessels are abnormal, or for using microglia as a target to modify vascular function.Read moreRead less
Identification of causal variants for complex traits. The aim of this project is to identify causal variants for complex traits in cattle and humans. Although most important traits in agriculture, medicine and evolution are complex traits, very few of the genetic variants affecting these traits are known and this undermines our understanding of how genetic variants affect a trait and practical uses of this knowledge. Huge datasets of individuals with genome sequence and phenotypes and new statis ....Identification of causal variants for complex traits. The aim of this project is to identify causal variants for complex traits in cattle and humans. Although most important traits in agriculture, medicine and evolution are complex traits, very few of the genetic variants affecting these traits are known and this undermines our understanding of how genetic variants affect a trait and practical uses of this knowledge. Huge datasets of individuals with genome sequence and phenotypes and new statistical methods provide the opportunity to close this gap. The outcome will be identification of many genomic variants causing variation in complex traits. This will benefit scientific understanding of complex traits and the ability to predict traits for individuals from their genome sequence.Read moreRead less
Digitally-Integrated Smart Sensing of Diverse Airborne Grass Pollen Sources. Grass pollen is the main outdoor allergen source globally, triggering hayfever and asthma in up to 500 million people. With over 10,000 species, the influence of grass type, location and climate on pollen in the air is not yet known. This is a key issue since subtropical and temperate grasses differ in response to environmental factors. The project aims to use artificial intelligence on digital camera images to learn to ....Digitally-Integrated Smart Sensing of Diverse Airborne Grass Pollen Sources. Grass pollen is the main outdoor allergen source globally, triggering hayfever and asthma in up to 500 million people. With over 10,000 species, the influence of grass type, location and climate on pollen in the air is not yet known. This is a key issue since subtropical and temperate grasses differ in response to environmental factors. The project aims to use artificial intelligence on digital camera images to learn to see local grass flowers and integrate this with air sensors trained to detect grass pollen types. The expected outcomes are new capacities to track airborne grass pollen types. These outcomes can transform how pollen can be monitored to reduce the burden of allergies, and provide evidence of changing airborne pollen loads.
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Australian Laureate Fellowships - Grant ID: FL230100023
Funder
Australian Research Council
Funding Amount
$3,362,355.00
Summary
Highly efficient microscale liquid handling and bio interfacing. The aim is to establish the exciting new field of micro elastofluidics, enabling the development of a highly competitive, sovereign capability in Australia, utilising flexibility and stretchability for efficient and precise handling of tiny volumes of liquid. The program will fill a critical gap in fundamental knowledge in fluid-structure interactions, leading to the development of wearable and implantable devices. The expected out ....Highly efficient microscale liquid handling and bio interfacing. The aim is to establish the exciting new field of micro elastofluidics, enabling the development of a highly competitive, sovereign capability in Australia, utilising flexibility and stretchability for efficient and precise handling of tiny volumes of liquid. The program will fill a critical gap in fundamental knowledge in fluid-structure interactions, leading to the development of wearable and implantable devices. The expected outcomes include innovative platform technologies for sample storage, handling and unique device-human interfaces with broad applications in health and defence. Expected benefits include enhanced capabilities in medical diagnostics, defence force protection and Australia’s sovereign high-tech manufacturing.Read moreRead less
Defining the molecular basis for Salmonella persistence. Salmonella infections in animals and humans place significant burdens on the agri-food and healthcare sectors. All mammals and avian species can become chronically infected with Salmonella and such chronic carriage is a reservoir for disease and outbreaks in other animals and humans. Significant gaps in our understanding of Salmonella infection remain, including the molecular mechanisms involved in establishing a chronic carrier state. We ....Defining the molecular basis for Salmonella persistence. Salmonella infections in animals and humans place significant burdens on the agri-food and healthcare sectors. All mammals and avian species can become chronically infected with Salmonella and such chronic carriage is a reservoir for disease and outbreaks in other animals and humans. Significant gaps in our understanding of Salmonella infection remain, including the molecular mechanisms involved in establishing a chronic carrier state. We identified several Salmonella specific genes and subsequent murine studies revealed that a Salmonella mutant lacking these genes is attenuated in mice and especially in the gallbladder. In this project we seek to understand the molecular basis for attenuation and the contribution of each protein to diseaseRead moreRead less
High-throughput single-molecule directed evolution. DNA polymerases are essential enzymes in many biotechnological tools, including DNA sequencing and PCR tests. However, existing DNA polymerases have limitations, resulting in inaccuracies and inefficiencies. Existing methods to improve polymerases lack sensitivity to screen for subtle, yet pivotal traits. This project aims to overcome this limitation by developing a new single-molecule directed-evolution system to evolve better polymerases. Wit ....High-throughput single-molecule directed evolution. DNA polymerases are essential enzymes in many biotechnological tools, including DNA sequencing and PCR tests. However, existing DNA polymerases have limitations, resulting in inaccuracies and inefficiencies. Existing methods to improve polymerases lack sensitivity to screen for subtle, yet pivotal traits. This project aims to overcome this limitation by developing a new single-molecule directed-evolution system to evolve better polymerases. With this new technology we aim to identify DNA polymerases with improved performance that benefit biotechnological applications. Additionally, these single-molecule directed-evolution methods will benefit the wider scientific community and lay the foundation for further advances in directed evolution.Read moreRead less
National Non-human Primate Breeding And Research Facility
Funder
National Health and Medical Research Council
Funding Amount
$2,640,742.00
Summary
Some biomedical research is best undertaken on primates, in order to allow the greatest relevance to understanding health and disease in humans. Examples of such research include studies into diseases like HIV-AIDS and much of the research into understanding the human brain and nervous system. The National Health and Medical Research Committee (NHMRC), through its Animal Welfare Committee, has taken an international leadership position in ensuring that any non-human primates used for biomedical ....Some biomedical research is best undertaken on primates, in order to allow the greatest relevance to understanding health and disease in humans. Examples of such research include studies into diseases like HIV-AIDS and much of the research into understanding the human brain and nervous system. The National Health and Medical Research Committee (NHMRC), through its Animal Welfare Committee, has taken an international leadership position in ensuring that any non-human primates used for biomedical research are bred and housed in the best possible facilities and looked after with the highest level of care available. To ensure this quality of care, it is NHMRC policy to only use animals that have been bred and reared specifically for research purposes. The National Non-Human Primate Breeding and Research Facility, hosted by Monash University, ensures that Australian community has access to macaque monkeys and marmosets to carry out research under the highest quality conditions. Additionally the colonies will provide a key resource in any national response to pandemics and bioterrorism for vaccine and response development.Read moreRead less