Structural Basis For Targeting Wnt Signalling Pathway In Cancer
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Cells sense and respond to a variety of stimuli by activating different signaling pathways. The Wnt pathway is important in embryonic development as it controls cell division and specialization. In adults, dysregulation of this pathway can lead to aberrant cell division and cancer. This proposal will use structural biology to look at several steps of this pathway at the molecular level. This will provide answers on how this pathway works and will lead to new ways to target it therapeutically.
Using Protein Structure And Dynamics To Facilitate Drug Discovery
Funder
National Health and Medical Research Council
Funding Amount
$1,512,250.00
Summary
G protein-coupled receptors (GPCRs) are the largest family of membrane proteins in the human genome, and drugs targeting these receptors account for 35% of marketed drugs. This project aims to determine atomic-level structural information of how drugs bind and specifically interact with therapeutically relevant GPCRs. Outcomes of this research will facilitate the design of future development of selective and effective drugs.