Novel Nanotechnology Strategies For Drug Co-delivery And Combined Therapies In The Brain
Funder
National Health and Medical Research Council
Funding Amount
$1,512,250.00
Summary
Key challenges for treating brain diseases include effective delivery of drugs into the brain and targeted delivery to pathogenic areas. I have developed two world-first drug delivery systems that address these challenges. This project will expand their loading and brain delivery capability to deliver a broad range of novel multiple therapeutics to target sites in the brain. Human brain disease models will be used for systematic preclinical evaluation of novel delivery systems and therapeutics.
A Long-Lasting Oral Drug Delivery System Using Spiky Silica Nanoparticles
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
This project aims to develop a novel silica nanoparticle-based delivery system for long-lasting oral drug delivery. The particles will be engineered with a spiky morphology that will increase adhesion to the gastrointestinal tract enabling sustained drug release for days or even weeks. Longer lasting oral drug formulations would make it much easier for patients to adhere to the treatment schedules required in chronic diseases like HIV and increase the effectiveness of therapy.
Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliance ....Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliances with the government, industry and community partners will develop a practice framework to prevent everyday harms and the escalation to abuse, and to promote safety and wellbeing. The research has policy benefits for capacity-building in the sector to act on the rights and voices of people with disability. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100903
Funder
Australian Research Council
Funding Amount
$451,885.00
Summary
Charitable triad: How donors, beneficiaries, & fundraisers influence giving. This project aims to test a new model of charitable giving to examine how donors, beneficiaries, and fundraisers together influence donor decisions. Until now, no holistic model has existed to explain donor behaviour: past research has focused on donors but neglected beneficiaries and fundraisers. This project is expected to provide evidence for a new bedrock theory of philanthropy. Findings can also inform practitioner ....Charitable triad: How donors, beneficiaries, & fundraisers influence giving. This project aims to test a new model of charitable giving to examine how donors, beneficiaries, and fundraisers together influence donor decisions. Until now, no holistic model has existed to explain donor behaviour: past research has focused on donors but neglected beneficiaries and fundraisers. This project is expected to provide evidence for a new bedrock theory of philanthropy. Findings can also inform practitioner toolkits, offering advice to nonprofits on how to raise money effectively by understanding how the particular organisation and its beneficiaries can influence donor decisions. By helping ensure the survival of charities, this research will contribute to the delivery of essential social services that benefit many Australians.Read moreRead less
Synergising nanoemulsion and lipid biomimetic design for advanced delivery. This project aims to identify the critical design characteristics of lipid formulations of lipid-modified probes or drugs (lipid biomimetics) that together promote integration into lipid absorption pathways and target the lymphatic system that drains the small intestine. This has significant potential since the intestinal lymphatic system is a key immune tissue, the site of immune response to autoantigens and antigens de ....Synergising nanoemulsion and lipid biomimetic design for advanced delivery. This project aims to identify the critical design characteristics of lipid formulations of lipid-modified probes or drugs (lipid biomimetics) that together promote integration into lipid absorption pathways and target the lymphatic system that drains the small intestine. This has significant potential since the intestinal lymphatic system is a key immune tissue, the site of immune response to autoantigens and antigens derived from food and the microbiome. The project will deliver a design roadmap of the required characteristics for lymphatic targeting, and in particular, will identify novel lipid nanoemulsions that work synergistically with lipid biomimetics to enhance lymphatic imaging and delivery applications.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101175
Funder
Australian Research Council
Funding Amount
$408,643.00
Summary
The asset state: Comparing new models for financing public investment. This project aims to investigate policy models that account for public spending as an asset rather than a cost. The project expects to build knowledge about how changes in the way governments budget for and deliver funding create new options for public investment. The project develops a comparative study of the relationship between accounting reforms and financing models for higher education, social housing and renewable ener ....The asset state: Comparing new models for financing public investment. This project aims to investigate policy models that account for public spending as an asset rather than a cost. The project expects to build knowledge about how changes in the way governments budget for and deliver funding create new options for public investment. The project develops a comparative study of the relationship between accounting reforms and financing models for higher education, social housing and renewable energy in Australia and the UK. Expected outcomes include conceptualising new spaces of fiscal power in the 'asset state' and developing tools for policy makers to guide budgetary choices. This should provide significant benefits by identifying equitable and sustainable ways to pay for critical services and infrastructure.Read moreRead less
The production, use and effect of social work research. This project aims to reform social work research to improve the quality and effectiveness of human services. The human services industry is vital to many people’s quality of life, but lacks innovation and struggles to demonstrate its effectiveness. Crucially for social work, research expands thinking about how to respond to social disadvantage. This project intends to examine the scope and quality of Australian social work research in child ....The production, use and effect of social work research. This project aims to reform social work research to improve the quality and effectiveness of human services. The human services industry is vital to many people’s quality of life, but lacks innovation and struggles to demonstrate its effectiveness. Crucially for social work, research expands thinking about how to respond to social disadvantage. This project intends to examine the scope and quality of Australian social work research in child protection, disability services, and aged care; assess the use of this research to the human services sector and its effect on generating innovation; and develop strategies to advance the production, uptake, and effect of social work research.Read moreRead less
Adjudicating rights for a sustainable National Disability Insurance Scheme. The aim of the National Disability Insurance Scheme is to redress unfairness for disabled Australians. The sensitive question for government and citizens is how to determine what support is fair? The goal is support based on the perceived needs and choices of individuals. The government is additionally concerned to ensure financial sustainability by limiting expectations about reasonable and necessary support. This proje ....Adjudicating rights for a sustainable National Disability Insurance Scheme. The aim of the National Disability Insurance Scheme is to redress unfairness for disabled Australians. The sensitive question for government and citizens is how to determine what support is fair? The goal is support based on the perceived needs and choices of individuals. The government is additionally concerned to ensure financial sustainability by limiting expectations about reasonable and necessary support. This project will identify the dominant operating principles and debates concerning funded support, by analysing relevant frameworks, decisions, appeals and internal reviews. By taking an administrative justice perspective, it contributes to a critical debate about the values guiding funded support decisions and fairness outcomes.Read moreRead less
Building connections: schools as community hubs. This project aims to support school systems and planning authorities enhance engagement between schools and local communities. The key objective is to advance the cost-effective development of the infrastructure required to deliver community programs and services from school sites, in addition to education programs for school-aged students. The project expects to generate new knowledge about how best to plan, design, govern and manage facilities a ....Building connections: schools as community hubs. This project aims to support school systems and planning authorities enhance engagement between schools and local communities. The key objective is to advance the cost-effective development of the infrastructure required to deliver community programs and services from school sites, in addition to education programs for school-aged students. The project expects to generate new knowledge about how best to plan, design, govern and manage facilities and infrastructure to enable schools to operate successfully as more than a school, encouraging the development of resilient and connected communities. The outcomes are expected to include a development framework for maximising schools as community hubs.Read moreRead less
Understanding production and application of alpha emitting radionuclides. This project aims to develop new materials to improve the efficiency of production of radionuclides, as well as tools to improve our understanding of isotope decay products to to improve efficiency of delivery. High performance polymers will be evaluated to establish optimal design properties for enhanced radionuclide collection from novel generators of isotopic lead (Pb-212), and new methods will be developed to improve u ....Understanding production and application of alpha emitting radionuclides. This project aims to develop new materials to improve the efficiency of production of radionuclides, as well as tools to improve our understanding of isotope decay products to to improve efficiency of delivery. High performance polymers will be evaluated to establish optimal design properties for enhanced radionuclide collection from novel generators of isotopic lead (Pb-212), and new methods will be developed to improve understanding of isotope product stability. Anticipated outcomes will provide greater production and utility of radioisotopes in radiopharmaceuticals, while building strong ties with partner AdvanCell Isotopes. This could improve manufacture of radionuclides, expanding capability and applications in radiopharmaceuticals.Read moreRead less