Phase III Trial Of Radical Chemo-radiation Vs Radiation Alone In The Management Of Localised Bladder TCC.
Funder
National Health and Medical Research Council
Funding Amount
$194,875.00
Summary
This trial aims to see if the combination of Chemotherapy and Radiation treatment is indeed superior in eradicating the tumor and preserving the Bladder in a greater number of patients as compared to Radiation treatment alone. If the final results from this study do show chemoradiotherapy to be significantly superior to radiation alone, without an increase in morbidity ( especially long term side effects ) , this may lay the platform for a greater proportion of patients with localised bladder ca ....This trial aims to see if the combination of Chemotherapy and Radiation treatment is indeed superior in eradicating the tumor and preserving the Bladder in a greater number of patients as compared to Radiation treatment alone. If the final results from this study do show chemoradiotherapy to be significantly superior to radiation alone, without an increase in morbidity ( especially long term side effects ) , this may lay the platform for a greater proportion of patients with localised bladder cancer, being in the first instance considered for this organ( bladder) preserving approach something which has become a reality at a number of other sites of cancer with the use of multimodality treatment.Read moreRead less
Non-neuronal ATP: Regulation Of Release And Action In The Bladder
Funder
National Health and Medical Research Council
Funding Amount
$451,553.00
Summary
Incontinence disorders are costly and debilitating. How the bladder signals the normal sensation of fullness as well as the urgent need to void urine (urgency) is still not fully understood. The signaling molecule ATP is released during bladder stretch. Using animal and human bladder, we will study how the bladder lining is involved in this signaling process, by measuring how bladder chemicals interact with stretch to modulate ATP release, and how ATP can influence nerve impulses to the brain.
Cultural Heritage Site Significance, Management and Interpretation in China and Australia: A Comparative Analysis in a Cross-Cultural Framework. The Nara Document 1994 asserts that East Asians see 'cultural heritage' differently from Westerners and that conservation practice should reflect the culture in which it takes place. Given Australia's growing tourism links with China, and China's growing importance in the Asia-Pacific, it is timely to reflect on the Chinese understanding of cultural her ....Cultural Heritage Site Significance, Management and Interpretation in China and Australia: A Comparative Analysis in a Cross-Cultural Framework. The Nara Document 1994 asserts that East Asians see 'cultural heritage' differently from Westerners and that conservation practice should reflect the culture in which it takes place. Given Australia's growing tourism links with China, and China's growing importance in the Asia-Pacific, it is timely to reflect on the Chinese understanding of cultural heritage. Conversely China's relatively new cultural heritage industry can learn from Australian practice. This project aims at better mutual understanding by researching key issues of site significance, management and interpretation. The research will fill a gap in the literature and provide a model for further cross-cultural heritage analysis.Read moreRead less
The spread of cancer to other organs is responsible for 90% of cancer deaths. This proposal seeks to determine how urological tumours (prostate and bladder) spread around the body. Cancer cell and animal models are an integral component of the research, and together with data obtained in human cancer specimens provide a comprehensive, powerful approach to identify key pathways involved in tumour spread. This is critical for the design of new therapies to treat and-or prevent tumour spread.
Complex and nonlinear pattern analysis in architectural space, form and program: developing computational tools to support social and cultural design. In a country that is experiencing increasing urban density there is an urgent need for the development of tools and models for the production of socially and culturally responsive environments. The Fellowship develops a new quantitative and qualitative understanding of the experiential and semiotic characteristics of buildings. The project, assis ....Complex and nonlinear pattern analysis in architectural space, form and program: developing computational tools to support social and cultural design. In a country that is experiencing increasing urban density there is an urgent need for the development of tools and models for the production of socially and culturally responsive environments. The Fellowship develops a new quantitative and qualitative understanding of the experiential and semiotic characteristics of buildings. The project, assisted by developments in robotics technology, produces a leading-edge computational model for analysing complex and non-linear patterns in architectural space, form and program from a social and cultural perspective. Such a model will assist design practitioners, scholars, town planners and policy writers to shape rich, responsive and inclusive architectural environments.Read moreRead less
East Perth Power Station and the Electrification of Western Australia: Interpretation of an Historic Site. Over the past century electricity has transformed people's lives. This project investigates the history of electrification in Australia through an interpretation of the historic site of East Perth power station, Australia's first centralised power station and now WA's most significant redevelopment site. The interconnection of electricity's technologies with human lives is the focus of this ....East Perth Power Station and the Electrification of Western Australia: Interpretation of an Historic Site. Over the past century electricity has transformed people's lives. This project investigates the history of electrification in Australia through an interpretation of the historic site of East Perth power station, Australia's first centralised power station and now WA's most significant redevelopment site. The interconnection of electricity's technologies with human lives is the focus of this research. It will result in scholarly outputs in print and digital form and provide thematic and narrative materials for best-practice historic heritage interpretation. The research is supported by industry partners including stakeholders in the East Perth power station site, community and government organisations, and researchers from four universities.Read moreRead less
UNESCO - Agency of Cultural Globalisation? Analysis of the Conflict between Universal Values and Local Cultural Identity in the Asia-Pacific Region. Economic globalisation is accompanied by cultural globalisation. Whether to accept or attempt to resist this impact on local cultures is a critical issue for communities and governments throughout the Asia-Pacific region. This project will identify and evaluate those activities of UNESCO and its associated bodies, ICOMOS, ICOM and ICCROM, that tend ....UNESCO - Agency of Cultural Globalisation? Analysis of the Conflict between Universal Values and Local Cultural Identity in the Asia-Pacific Region. Economic globalisation is accompanied by cultural globalisation. Whether to accept or attempt to resist this impact on local cultures is a critical issue for communities and governments throughout the Asia-Pacific region. This project will identify and evaluate those activities of UNESCO and its associated bodies, ICOMOS, ICOM and ICCROM, that tend to impose a common stamp on cultures across the world, as well as the local resistance to those activities. Four fields covering tangible and intangible culture will be investigated: heritage places, museums, folklife and heritage education. Outcomes include improved heritage management; outputs include a book and refereed journal articles.Read moreRead less