Engineering an artificial protein molecular motor. This project aims to use non-motor protein building blocks to construct an artificial protein motor. Nature already uses nanotechnology as the basis for all its machinery, and uses proteins to construct machines. Each protein component in the motor will have a well-understood function; this artificial protein will elucidate how it converts chemical energy to motion. This process is not understood as molecular motors do not obey the same principl ....Engineering an artificial protein molecular motor. This project aims to use non-motor protein building blocks to construct an artificial protein motor. Nature already uses nanotechnology as the basis for all its machinery, and uses proteins to construct machines. Each protein component in the motor will have a well-understood function; this artificial protein will elucidate how it converts chemical energy to motion. This process is not understood as molecular motors do not obey the same principles as macroscopic machines. Comparing the artificial motor with biological motors will provide insight into the workings of natural motors. This project should lead to molecular motors for nanobiotechnology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100163
Funder
Australian Research Council
Funding Amount
$639,369.00
Summary
Nano-bioscience imaging facility. This project aims to investigate the interactions between nano-engineered materials and biological systems through the use of cutting-edge imaging technologies. The project will consist of an ImageStreamX Imaging Flow Cytometer and a Coherent Anti-Stokes Raman Scattering Microscope. Together these will allow high throughput and label-free imaging of cell-nanomaterial interactions, which will underpin research by leading researchers as well as promoting collabora ....Nano-bioscience imaging facility. This project aims to investigate the interactions between nano-engineered materials and biological systems through the use of cutting-edge imaging technologies. The project will consist of an ImageStreamX Imaging Flow Cytometer and a Coherent Anti-Stokes Raman Scattering Microscope. Together these will allow high throughput and label-free imaging of cell-nanomaterial interactions, which will underpin research by leading researchers as well as promoting collaborations between researchers in the physical and life sciences. This will provide significant benefits, such as the development of new materials for potential applications in nano-bioscience.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100087
Funder
Australian Research Council
Funding Amount
$1,100,000.00
Summary
Plasma-focused ion beam for nanoscale characterisation of materials. This project aims to enable research programmes in functional materials to characterise materials using xenon-plasma focused ion beam (FIB) instrumentation. The plasma FIB, with its fast milling speeds across large areas, will enable new three-dimensional imaging experiments and types of transmission electron microscopy samples. This will have applications in engineering, photovoltaics and environmental geosciences, which all n ....Plasma-focused ion beam for nanoscale characterisation of materials. This project aims to enable research programmes in functional materials to characterise materials using xenon-plasma focused ion beam (FIB) instrumentation. The plasma FIB, with its fast milling speeds across large areas, will enable new three-dimensional imaging experiments and types of transmission electron microscopy samples. This will have applications in engineering, photovoltaics and environmental geosciences, which all need to analyse materials on a nanometre scale.Read moreRead less
Novel graphene-based soft materials for versatile applications. This research program will develop new techniques to convert natural graphite into new carbon nanomaterials for use in energy storage/conversion devices, water purification, sensors and biomedical devices. It will enable many technological innovations in related areas and enhance Australia's engineering and manufacturing innovations.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100156
Funder
Australian Research Council
Funding Amount
$289,500.00
Summary
3D Two-Photon Nanoprinter for Advanced Multi-Functional Materials & Devices. The Nanoscribe Photonic Professional GT2 Two-Photon 3D Printer enables tailoring materials’ architecture at nanoscale. This results in unique optical, mechanical, electrical, chemical, biochemical, and acoustic properties enabling a wealth of cutting-edge research activities in variety of fields including mechanical/optical/electrical metamaterials, bioinspired hard/soft materials, biomaterials (e.g., structured cell-ti ....3D Two-Photon Nanoprinter for Advanced Multi-Functional Materials & Devices. The Nanoscribe Photonic Professional GT2 Two-Photon 3D Printer enables tailoring materials’ architecture at nanoscale. This results in unique optical, mechanical, electrical, chemical, biochemical, and acoustic properties enabling a wealth of cutting-edge research activities in variety of fields including mechanical/optical/electrical metamaterials, bioinspired hard/soft materials, biomaterials (e.g., structured cell-tissue interfaces), biomedical devices (implantable devices and drug-delivery systems), nanofluidics, and photonic crystals. In each of these fields, we will use GT2 to print variety of polymers, hydrogels, metals and ceramics, for example by printing polymer-derived nanoceramics that will be simultaneously strong and tough.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100051
Funder
Australian Research Council
Funding Amount
$320,000.00
Summary
An advanced X-ray facility for surface and in-situ materials characterization. An advanced X-ray facility for surface and in-situ materials characterisation: Materials properties are crucial to the performance of devices and structures, and detailed characterisation at a molecular level is important for optimizing new materials. X-rays are a powerful means of achieving the required level of detail in structural characterisation. The aim of this project is to make available an extremely bright X- ....An advanced X-ray facility for surface and in-situ materials characterization. An advanced X-ray facility for surface and in-situ materials characterisation: Materials properties are crucial to the performance of devices and structures, and detailed characterisation at a molecular level is important for optimizing new materials. X-rays are a powerful means of achieving the required level of detail in structural characterisation. The aim of this project is to make available an extremely bright X-ray source with a suite of advanced analytical tools, including surface structural analysis by reflectometry and grazing incidence diffraction and materials structure determination using powder diffraction and microdiffraction at high and low temperatures. The functions of this facility are broad and its applications include materials science, organic electronics, biomaterials and engineering.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100104
Funder
Australian Research Council
Funding Amount
$1,175,000.00
Summary
An aberration corrected analytical Transmission Electron Microscope for nanoscale characterisation of materials. This new-generation scanning transmission electron microscope enables selective determination of atomic and chemical structure within sub-nanometre regions of materials. It will enable cutting-edge developments in nanotechnology, materials science and engineering; technologies which underpin progress in our modern society.
Discovery Early Career Researcher Award - Grant ID: DE220100205
Funder
Australian Research Council
Funding Amount
$433,000.00
Summary
Engineering micropatterned surfaces for cell mechanics and mechanobiology. This project aims to engineer a highly versatile micropatterned surface that can be used to culture and study cells. This project expects to generate a unique microtechnology, as well as new knowledge in surface science and cell mechanics by elucidating the relationship between controlled surface wettability and cell behaviour. The expected outcomes of this project include a low-cost and highly engineered tissue culture t ....Engineering micropatterned surfaces for cell mechanics and mechanobiology. This project aims to engineer a highly versatile micropatterned surface that can be used to culture and study cells. This project expects to generate a unique microtechnology, as well as new knowledge in surface science and cell mechanics by elucidating the relationship between controlled surface wettability and cell behaviour. The expected outcomes of this project include a low-cost and highly engineered tissue culture tool that controls cellular functions, revolutionising practices in stem cell engineering. The platform technology has a great potential for commercialisation and enhancing Australian research capacity through international and interdisciplinary collaborations and will directly benefit the Australian biotech industry.Read moreRead less
Micro-electrofluidic platforms for monitoring 3D human biological models. The ability to study living cells and human biological models (cell cultures) delivers greater understanding of basic biological function and response to applied (bio)chemical stimuli. Creating the physical environments to sustain biological models, and mimic natural conditions and fluidic pathways, is immensely challenging, yet essential to deliver meaningful observational data. This project will deliver this capability t ....Micro-electrofluidic platforms for monitoring 3D human biological models. The ability to study living cells and human biological models (cell cultures) delivers greater understanding of basic biological function and response to applied (bio)chemical stimuli. Creating the physical environments to sustain biological models, and mimic natural conditions and fluidic pathways, is immensely challenging, yet essential to deliver meaningful observational data. This project will deliver this capability through the convergence of expertise and innovation in analytical chemistry, materials science and cellular biology, ultilising the latest technology and understanding of 3D micro/electrofluidics, to enable the study and stimulation of advanced biological models, sustained within precisely controlled 3D micro-environments.Read moreRead less
Nanoengineering of Biomaterial Surfaces to Tailor Innate Immune Responses. The overarching aim of this project is to provide a mechanistic understanding of how surface nanotopography affects inflammatory responses. Recently, we showed that surface nanotopography induced conformational changes in adsorbed proteins can activate or deactivate immune cells. These exciting findings are important because they show that it may be possible to engineer the nanotopography of a biomedical device surface in ....Nanoengineering of Biomaterial Surfaces to Tailor Innate Immune Responses. The overarching aim of this project is to provide a mechanistic understanding of how surface nanotopography affects inflammatory responses. Recently, we showed that surface nanotopography induced conformational changes in adsorbed proteins can activate or deactivate immune cells. These exciting findings are important because they show that it may be possible to engineer the nanotopography of a biomedical device surface in a manner which leads to a desired and predictable level of inflammation. The outcomes of the project will create new fundamental knowledge that in the future can instruct the development of the next generation of biomaterials capable of controlling and directing the body’s inflammatory responses.Read moreRead less