Theory and Applications of Computer-Intensive Statistical Methods. The availability of powerful computing equipment has had a dramatic impact on statistical methods and thinking. It has motivated development of novel approaches to data analysis, whose conception
and appreciation, even their application, often demand sophisticated and complex theoretical methods. In this context, the project will develop new approaches to solving non-standard statistical problems. These techniques will eithe ....Theory and Applications of Computer-Intensive Statistical Methods. The availability of powerful computing equipment has had a dramatic impact on statistical methods and thinking. It has motivated development of novel approaches to data analysis, whose conception
and appreciation, even their application, often demand sophisticated and complex theoretical methods. In this context, the project will develop new approaches to solving non-standard statistical problems. These techniques will either have direct application to solving practical problems of national or community concern, or provide a better understanding of the nature of such problems.Read moreRead less
Bio-inspired speech analysis: Specialised information processing of vocalisations in the auditory brainstem. This project has the potential to benefit bionic ear and hearing aid users through the development of signal processing methods that mimic the amazing abilities of the brain. Speech perception performance by bionic ear users has reached a plateau and these new strategies could produce the breakthrough needed to provide the next increase in performance. The benefit for greater improved hea ....Bio-inspired speech analysis: Specialised information processing of vocalisations in the auditory brainstem. This project has the potential to benefit bionic ear and hearing aid users through the development of signal processing methods that mimic the amazing abilities of the brain. Speech perception performance by bionic ear users has reached a plateau and these new strategies could produce the breakthrough needed to provide the next increase in performance. The benefit for greater improved hearing has enormous benefit and potential for improving the quality of life of the hearing impaired, especially those with severe and profound hearing loss. In addition, the algorithms may provide more robust automatic speech recognition, making this technology more useful in everyday situations; the markets that this would open up are enormous.Read moreRead less
Modelling with stochastic differential equations. We will develop methodology for modelling and analysis of phenomena subjected to random and uncertain influences, such as behaviour of investors in the market, evolution of economy, values of stocks and ant colonies. This methodology will enable scientists to achieve more accurate description and analysis of their models and provide better understanding of these phenomena. Creating the tools for understanding such complex systems will have far re ....Modelling with stochastic differential equations. We will develop methodology for modelling and analysis of phenomena subjected to random and uncertain influences, such as behaviour of investors in the market, evolution of economy, values of stocks and ant colonies. This methodology will enable scientists to achieve more accurate description and analysis of their models and provide better understanding of these phenomena. Creating the tools for understanding such complex systems will have far reaching benefits both nationally and internationally and will allow Australia to strengthen its position in international research. The project will also provide for postgraduate training and international scientific exchange.Read moreRead less
Stochastic systems with applications to Biology and Finance. This project is concerned with stochastic systems. These mathematical systems, which are controlled by statistical uncertainty and variability, have profound importance in the fields of biology and finance. They are recognised worldwide as being of primary scientific importance. Important questions to be examined are: 1) Branching processes in DNA Polymerase Chain Reaction, 2) long term stationarity in metastable systems, and 3) Sto ....Stochastic systems with applications to Biology and Finance. This project is concerned with stochastic systems. These mathematical systems, which are controlled by statistical uncertainty and variability, have profound importance in the fields of biology and finance. They are recognised worldwide as being of primary scientific importance. Important questions to be examined are: 1) Branching processes in DNA Polymerase Chain Reaction, 2) long term stationarity in metastable systems, and 3) Stochastic Volatility in Finance. The answers to these questions will underpin the statistical theory for potential breakthroughs in the respective areas. This project will contribute to the theory and applications of Stochastic Processes, as well as modelling in biology and finance.Read moreRead less
Stochastic methods for studying models of infection and abundance. The outcomes of this project will have immense benefit to Australia. They impact upon two areas of national importance, namely ensuring an environmentally sustainable Australia, and safeguarding Australia. In particular, the project will provide models, methodology and optimal strategies for sustainable use of Australia's biodiversity, for protecting Australia from invasive diseases and pests, and for protecting Australia from te ....Stochastic methods for studying models of infection and abundance. The outcomes of this project will have immense benefit to Australia. They impact upon two areas of national importance, namely ensuring an environmentally sustainable Australia, and safeguarding Australia. In particular, the project will provide models, methodology and optimal strategies for sustainable use of Australia's biodiversity, for protecting Australia from invasive diseases and pests, and for protecting Australia from terrorism and crime. Special focus will be given to the control of invasive species, the control of emerging infections, and the optimal allocation of resources. The current risks posed by invasive diseases and pests, and the alarming rate of destruction of biodiversity, warrant urgent funding of this project.Read moreRead less
Special Research Initiatives - Grant ID: SR0354793
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
A Neural Network: Understanding Brain Function. This proposal focuses on the mechanisms that regulate brain function, particularly those underpinning the changes in circuitry (plasticity) caused by altered inputs. As such, its core goal is to create an interface between researchers in the neurosciences, computational modelling, robotics and cognitive sciences in order to facilitate optimum collaborative interactions, identify key research questions and promote training opportunities across a mul ....A Neural Network: Understanding Brain Function. This proposal focuses on the mechanisms that regulate brain function, particularly those underpinning the changes in circuitry (plasticity) caused by altered inputs. As such, its core goal is to create an interface between researchers in the neurosciences, computational modelling, robotics and cognitive sciences in order to facilitate optimum collaborative interactions, identify key research questions and promote training opportunities across a multidisciplinary spectrum. This will drive an integrated and accelerated program of discovery and technological development, enhancing Australia's leadership in this crucial field and helping to highlight new biotechnology opportunities and capture social and economic benefits for the nation. Read moreRead less
Multi-scale modelling of cell migration in developmental biology. Interpretative and predictive tools are needed for the comprehensive understanding of directed cell migration in the medical sciences. Mathematical models and modelling methodologies developed in this project will make a significant contribution to the investigation of cell migration and the testing and generation of hypotheses. Such models are needed to understand observed cellular patterns. This project will contribute to knowle ....Multi-scale modelling of cell migration in developmental biology. Interpretative and predictive tools are needed for the comprehensive understanding of directed cell migration in the medical sciences. Mathematical models and modelling methodologies developed in this project will make a significant contribution to the investigation of cell migration and the testing and generation of hypotheses. Such models are needed to understand observed cellular patterns. This project will contribute to knowledge of normal and abnormal developmental processes, especially in embryonic growth. Understanding these processes should lead to prediction and treatment of congenital disorders and contribute to a healthy start to life.Read moreRead less
New approaches to inhibition of activity of HIV integrase. This project aims to assist in the development of novel anti-HIV drugs that will benefit the 17000 Australians and more than 33 million people worldwide who are currently suffering with this terrible disease. The project will utilise state-of-the-art approaches in structure-based drug design to identify and synthesise compounds as leads for the development of anti-HIV drugs. Furthermore, the project will provide invaluable training for t ....New approaches to inhibition of activity of HIV integrase. This project aims to assist in the development of novel anti-HIV drugs that will benefit the 17000 Australians and more than 33 million people worldwide who are currently suffering with this terrible disease. The project will utilise state-of-the-art approaches in structure-based drug design to identify and synthesise compounds as leads for the development of anti-HIV drugs. Furthermore, the project will provide invaluable training for the researchers involved and enhance the relationship between the academic and commercial collaborators.Read moreRead less
Multiscale stochastic modelling of tumour robustness. This project will develop cutting-edge modelling methodologies of systems biology and innovative experimental techniques to investigate the principles of tumour initiation and progression, which lay at the heart of the national research priority Frontier Technologies for Building and Transforming Australian Industries. The primary outcome will be fundamental new paradigms explaining tumour initiation, cancer disease progression and the evolut ....Multiscale stochastic modelling of tumour robustness. This project will develop cutting-edge modelling methodologies of systems biology and innovative experimental techniques to investigate the principles of tumour initiation and progression, which lay at the heart of the national research priority Frontier Technologies for Building and Transforming Australian Industries. The primary outcome will be fundamental new paradigms explaining tumour initiation, cancer disease progression and the evolution of therapy resistance. The deep insights gained in this research have the potential for the optimal treatment strategies of cancer diseases, which is strongly relevant to promoting and maintaining good health for Australians.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989334
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
An integrated high-performance computational platform powering systems biology investigation. Systems biology is the study of the organism as a whole and provides a deeper understanding of biological processes than is possible by studying components separately. Recognised as essential for biological research, we propose to establish an advanced computational platform to study these processes at a systems level. Its hardware and specialised software will allow Australian researchers to examine co ....An integrated high-performance computational platform powering systems biology investigation. Systems biology is the study of the organism as a whole and provides a deeper understanding of biological processes than is possible by studying components separately. Recognised as essential for biological research, we propose to establish an advanced computational platform to study these processes at a systems level. Its hardware and specialised software will allow Australian researchers to examine complex pathways involved in animal and human health and disease, as well as in biotechnology and environmental processes. It will provide unique capabilities not currently available in Australia, and help Australian researchers remain internationally competitive in breakthrough science and frontier technologies.Read moreRead less