Improved Monte Carlo Methods for Estimation, Optimisation and Counting. The project will benefit the Australian society by building the theoretical and methodological foundations for the next generation of Monte Carlo techniques. The advancement of the knowledge in this area will provide important tools for solving complex estimation, optimisation and counting problems in engineering, statistics, computer science, mathematics and the physical and life sciences. As a result it will generate a com ....Improved Monte Carlo Methods for Estimation, Optimisation and Counting. The project will benefit the Australian society by building the theoretical and methodological foundations for the next generation of Monte Carlo techniques. The advancement of the knowledge in this area will provide important tools for solving complex estimation, optimisation and counting problems in engineering, statistics, computer science, mathematics and the physical and life sciences. As a result it will generate a competitive advantage for various sections of the Australian industry, including telecommunications, biotechnology and finance. The project will enable Australian researchers to continue to work at the forefront of this fast moving and exciting area of international research.Read moreRead less
Design of a Reference Methodology for Extended Enterprise Architecture. Enterprises have nowadays a very critical perception of the actual benefits of Information Technology (IT). Significant investments in IT infrastructures have been made. However, in many cases no monetary benefits could be demonstrated. Enterprises Architectures provide a way to link the business and the IT perspective. This project aims to develop an operational methodology with a solid theoretical foundation for the design ....Design of a Reference Methodology for Extended Enterprise Architecture. Enterprises have nowadays a very critical perception of the actual benefits of Information Technology (IT). Significant investments in IT infrastructures have been made. However, in many cases no monetary benefits could be demonstrated. Enterprises Architectures provide a way to link the business and the IT perspective. This project aims to develop an operational methodology with a solid theoretical foundation for the design of such Enterprise Architectures. The outcomes and the innovation of this project are an extension of the popular Zachman Framework. Integrated modelling techniques proposed within the Architecture of Integrated Information Systems will be used to populate this framework.Read moreRead less
Stochastic modelling of spatiotemporal nonlinear diffusion processes with multifractal characteristics. This research is relevant to solute transport and plume evolution in heterogeneous media. Detailed modelling of these processes is computer-intensive, while the diffusion models of this project offer a more economical alternative. Our study will also benefit the research on the salinity problem. Excessive demand for irrigation water to support agricultural production has stretched freshwater a ....Stochastic modelling of spatiotemporal nonlinear diffusion processes with multifractal characteristics. This research is relevant to solute transport and plume evolution in heterogeneous media. Detailed modelling of these processes is computer-intensive, while the diffusion models of this project offer a more economical alternative. Our study will also benefit the research on the salinity problem. Excessive demand for irrigation water to support agricultural production has stretched freshwater aquifers beyond their long-term yield. Large areas of land have been lost to saltwater intrusion. This proposal will provide suitable tools to predict the level and movement of saltwater in the aquifers. Application to the development of management strategies would bring direct benefit to coastal areas where salinity is a sustainability issue.Read moreRead less
Stochastic modelling and analysis of spatio-temporal processes with fractal characteristics. Interest has grown in recent years on the derivation of fractal models to represent certain physical phenomena such as diffusion and transport in porous media, oceanic and atmospheric turbulence, climatology, etc. This project focuses on the phenomenon of diffusion on domains with multifractal geometry. Recent advances in harmonic analysis on fractals and our own development of fractional generalized ran ....Stochastic modelling and analysis of spatio-temporal processes with fractal characteristics. Interest has grown in recent years on the derivation of fractal models to represent certain physical phenomena such as diffusion and transport in porous media, oceanic and atmospheric turbulence, climatology, etc. This project focuses on the phenomenon of diffusion on domains with multifractal geometry. Recent advances in harmonic analysis on fractals and our own development of fractional generalized random fields allow us to formulate a comprehensive program to tackle some key problems including modeling, processing and statistical estimation of fractional diffusion. Advances made in this program will in turn benefit the developments in related scientific fields.Read moreRead less
Assessment of the Seismic Hazard in South-East Queensland utilizing earthquake simulations. Assessment of seismic hazard in Australia is hampered by relatively few instrumental records of past earthquakes. Supercomputer simulations of long-term earthquake activity and strong ground motion, provide an alternative method for estimating the risk posed by earthquakes. The aim of this project is to construct a physical model for South-East Queensland incorporating the major faults and rock units of ....Assessment of the Seismic Hazard in South-East Queensland utilizing earthquake simulations. Assessment of seismic hazard in Australia is hampered by relatively few instrumental records of past earthquakes. Supercomputer simulations of long-term earthquake activity and strong ground motion, provide an alternative method for estimating the risk posed by earthquakes. The aim of this project is to construct a physical model for South-East Queensland incorporating the major faults and rock units of the region. In conjunction with earthquake simulation software of the Australian Computational Earth Systems Simulator, this model will be employed to analyse the spatial and temporal variability of earthquake activity and the ground motion resulting from these earthquakes.Read moreRead less
APEC Cooperation for Earthquake Simulation Visitors Program. This project aims to improve understanding of earthquakes through development of numerical simulation models for the earthquake generation process. Its centerpiece is a major international collaboration, achieved via a visitor exchange program between the headquarters of the APEC Cooperation for Earthquake Simulation in Australia and overseas centres of excellence. Earthquakes are one of the most costly and deadly natural disasters, a ....APEC Cooperation for Earthquake Simulation Visitors Program. This project aims to improve understanding of earthquakes through development of numerical simulation models for the earthquake generation process. Its centerpiece is a major international collaboration, achieved via a visitor exchange program between the headquarters of the APEC Cooperation for Earthquake Simulation in Australia and overseas centres of excellence. Earthquakes are one of the most costly and deadly natural disasters, and APEC member economies have a high earthquake risk. Recent analyses suggest earthquakes may dominate the loss potential in Australia. The complementary research programs offer an opportunity to achieve breakthrough advances in improved methods of earthquake forecasting and hazard quantification.Read moreRead less
Physiologically-based Pharmacokinetics And Pharmacodynamics Of Therapeutic Stem Cells For Liver Disease
Funder
National Health and Medical Research Council
Funding Amount
$848,710.00
Summary
This project focuses on the challenging area of effective and optimal dosing cell-based therapy for liver diseases. We will investigate the fate and therapeutic effects of natural, modified and artificial therapeutic cells in the body and in liver regions using a physiologically-based kinetic model. Our key goal is advance cell therapy by providing a better understanding and dosing guidelines.
Optimising Intervention Strategies To Reduce The Burden Of Group A Streptococcus In Aboriginal Communities
Funder
National Health and Medical Research Council
Funding Amount
$856,896.00
Summary
Skin sores are highly prevalent in remote Australian Indigenous communities and can lead to invasive infections and rheumatic heart disease. We will develop mathematical models to understand the transmission of skin sores, allowing us to define the optimal extent (household, community, region), timing and triggers for interventions to interrupt transmission. This will guide public health policy in reducing the prevalence of skin sores and scabies, and their accompanying disease burden.
Modelling The Biology And Transmission Of Influenza Virus - Learning From 1918-19 And Other Outbreaks
Funder
National Health and Medical Research Council
Funding Amount
$114,222.00
Summary
In preparing for a future pandemic of influenza, it is important to learn as much as possible from what happened in the past, particularly from the devastating pandemic of 1918-19. This project will collate detailed information about the spread of influenza in past outbreaks and create a publicly accessible data-base. Mathematical methods will be used to analyse historic and contemporary data, so as to provide better understanding of the spread of influenza, and of the likely effects of social a ....In preparing for a future pandemic of influenza, it is important to learn as much as possible from what happened in the past, particularly from the devastating pandemic of 1918-19. This project will collate detailed information about the spread of influenza in past outbreaks and create a publicly accessible data-base. Mathematical methods will be used to analyse historic and contemporary data, so as to provide better understanding of the spread of influenza, and of the likely effects of social and medical measures for its control. An important theme of the project is to consolidate our knowledge about how past exposure to non-pandemic influenza could provide short-lived protection against any new pandemic, and to explore the implications of this for prevention today. Another theme is to explore the severity of influenza during pandemics, and to identify social and medical factors that might reduce the dose of virus transmitted, or otherwise reduce the severity of infection. The insights from the modeling will also help to identify gaps in knowledge and understanding about the basic biology of influenza, stimulate new research to fill those gaps, and thus offer the prospect of more effective vaccines and treatments for the future control of influenza.Read moreRead less
Coding Error Isolation in Computerised Simulation Models with Application to Wastewater Treatment Systems. Simulation code verification through program testing and debugging is crucially important, but is tedious and often difficult. A novel approach will be studied in this project. The approach involves detecting coding errors through back-to-back testing using two independently implemented versions of a given mathematical model, and isolating the coding errors through systematically analysing ....Coding Error Isolation in Computerised Simulation Models with Application to Wastewater Treatment Systems. Simulation code verification through program testing and debugging is crucially important, but is tedious and often difficult. A novel approach will be studied in this project. The approach involves detecting coding errors through back-to-back testing using two independently implemented versions of a given mathematical model, and isolating the coding errors through systematically analysing the test error signal generated (the difference between the outputs of the two models). This is possible because one of the two versions is implemented in such a way that the test error carries an easily identifiable feature. This project could revolutionize the area of model verification.Read moreRead less