Human Leukocyte Antigen-A and -B regulation of Natural Killer cell function. The aim of this project is to determine how genetic variation in the genes encoding cell surface receptors expressed by innate lymphocytes and the molecules they recognise diversifies their capacity to sense and respond to infection. This knowledge is critical for understanding why there are intrinsic differences between individuals with respect to their capacity to respond to different types of infection and will ultim ....Human Leukocyte Antigen-A and -B regulation of Natural Killer cell function. The aim of this project is to determine how genetic variation in the genes encoding cell surface receptors expressed by innate lymphocytes and the molecules they recognise diversifies their capacity to sense and respond to infection. This knowledge is critical for understanding why there are intrinsic differences between individuals with respect to their capacity to respond to different types of infection and will ultimately inform our capacity to better deploy personalised medicines.Read moreRead less
The fundamental equations for inversion of operator pencils. This project seeks to deepen understanding of how complex systems may be significantly changed by incremental changes to ambient conditions. Mathematical models of complex systems (climate change processes, optimal driving strategies, efficient distribution policies, effective search routines) often depend on key parameters. If small perturbations to the parameters cause large changes to the solution, then the perturbations are said to ....The fundamental equations for inversion of operator pencils. This project seeks to deepen understanding of how complex systems may be significantly changed by incremental changes to ambient conditions. Mathematical models of complex systems (climate change processes, optimal driving strategies, efficient distribution policies, effective search routines) often depend on key parameters. If small perturbations to the parameters cause large changes to the solution, then the perturbations are said to be singular. This project aims to reveal the underlying mathematical structures and develop new computational algorithms to analyse a general class of perturbed systems both locally near an isolated singularity and globally. It plans to use these algorithms to solve systems of equations, calculate generalised inverse operators, examine perturbed Markov processes, and estimate exit times from meta-stable states in stochastic population dynamics.Read moreRead less
ARC Financial Integrity Research Network. The integrity of the financial system is constantly under stress because of the development of ever more complex financial instruments, structures and strategies, and the associated research technologies that continues to accelerate worldwide. FIRN's vision is to harness the considerable strengths of Australia's internationally renowned finance, accounting and economics researchers into a research agenda to address issues concerning the integrity of the ....ARC Financial Integrity Research Network. The integrity of the financial system is constantly under stress because of the development of ever more complex financial instruments, structures and strategies, and the associated research technologies that continues to accelerate worldwide. FIRN's vision is to harness the considerable strengths of Australia's internationally renowned finance, accounting and economics researchers into a research agenda to address issues concerning the integrity of the financial system. It will enable Australian research in this area to match the scale and impact of similar research in other major international financial centres, and play an essential role in placing Australia among the world's leaders in financial markets related research.Read moreRead less
The prediction of sleep/wake behaviour based on physiological and social factors. The prevalence of shiftwork has increased in Australia over the last few decades. Shiftworkers obtain less sleep, have greater difficulty maintaining good relationships, have poorer health, and are more likely to be injured at work than others. Using the largest dataset of its kind, we will substantially contribute to understanding the relationships between work hours, sleep, performance and safety. Ultimately, the ....The prediction of sleep/wake behaviour based on physiological and social factors. The prevalence of shiftwork has increased in Australia over the last few decades. Shiftworkers obtain less sleep, have greater difficulty maintaining good relationships, have poorer health, and are more likely to be injured at work than others. Using the largest dataset of its kind, we will substantially contribute to understanding the relationships between work hours, sleep, performance and safety. Ultimately, the project will answer a question critical to workplace safety - how much time off between shifts is needed to be alert and safe at work? The project will also produce tools to help industry design fatigue-friendly rosters, improving the safety, productivity and general well-being of shiftworkers in Australia and overseas.Read moreRead less
Sewer Monitoring and Management in the Digital Era. Overflow, flooding, corrosion, and odorous emissions are persistent issues for utilities managing sewers. Current sewer maintenance is reactive, and focuses on solving problems in local networks, despite that optimal solutions require a system-wide approach. Capitalising on recent development in IoT sensors, wireless transmission, and machine learning, this multidisciplinary project aims to develop digital-twin supported data analytics for proa ....Sewer Monitoring and Management in the Digital Era. Overflow, flooding, corrosion, and odorous emissions are persistent issues for utilities managing sewers. Current sewer maintenance is reactive, and focuses on solving problems in local networks, despite that optimal solutions require a system-wide approach. Capitalising on recent development in IoT sensors, wireless transmission, and machine learning, this multidisciplinary project aims to develop digital-twin supported data analytics for proactive sewer management including network-wide real-time control. The project aims to generate significant social, environmental and economic benefits by enabling utilities to better protect public and environmental health, reduce sewer odour and greenhouse gas emissions, and extend sewer asset life.Read moreRead less
Network-wide sewer odour and corrosion management by model predictive control. Network-wide sewer odour and corrosion management by model predictive control. This project aims to develop and demonstrate, through real-life field studies, a model predictive control approach that achieves cost-effective network-wide mitigation of hydrogen sulphide. The lack of suitable methodologies to support the control designs of chemical dosing units and sewage pumping stations makes network-wide sewer corrosio ....Network-wide sewer odour and corrosion management by model predictive control. Network-wide sewer odour and corrosion management by model predictive control. This project aims to develop and demonstrate, through real-life field studies, a model predictive control approach that achieves cost-effective network-wide mitigation of hydrogen sulphide. The lack of suitable methodologies to support the control designs of chemical dosing units and sewage pumping stations makes network-wide sewer corrosion and odour management a problem. Innovative control methodology will simultaneously manipulate chemical dosing unit(s) and selected sewage pumping station(s), based on real-time prediction of sewage flows and characteristics both at sources and across the network, to ensure optimal delivery of dosed chemicals to mitigate hydrogen sulphide.Read moreRead less
New biocatalysts for selective chemical oxidations under extreme conditions. This project will identify and design new enzyme biocatalysts which function under extreme conditions such as elevated temperature and high concentrations of peroxides. These enzymes will be sourced from microorganisms which are located in extreme biological environments e.g. hot springs (the so-called extremophiles). The expected outcome of this project are the identification of robust enzymes which can catalyse select ....New biocatalysts for selective chemical oxidations under extreme conditions. This project will identify and design new enzyme biocatalysts which function under extreme conditions such as elevated temperature and high concentrations of peroxides. These enzymes will be sourced from microorganisms which are located in extreme biological environments e.g. hot springs (the so-called extremophiles). The expected outcome of this project are the identification of robust enzymes which can catalyse selective oxidation reactions in complex organic molecules, such as steroids. The new biocatalysts developed in this project will have significant benefit in the development of new routes to access bespoke molecules of value in fine chemical synthesis and drug development.
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Enhancing Genomic Prediction for Changing Environments in Wheat. Adverse weather is the primary risk faced by the Australian agriculture industry. This Project aims to develop the next generation of agriculture tools to unlock natural potential in wheat and improve yield stability across seasons and regions. Drawing on crop physiology, genetics and integrated modelling, this Project expects to generate new knowledge and technologies to untangle genetic and environmental interactions that affect ....Enhancing Genomic Prediction for Changing Environments in Wheat. Adverse weather is the primary risk faced by the Australian agriculture industry. This Project aims to develop the next generation of agriculture tools to unlock natural potential in wheat and improve yield stability across seasons and regions. Drawing on crop physiology, genetics and integrated modelling, this Project expects to generate new knowledge and technologies to untangle genetic and environmental interactions that affect productivity, enhance predictive capability, and initiate advanced breeding strategies to develop new crop varieties with superior resilience against changing climates. This should provide significant benefits, such as profit stability for wheat growers, elevated global market position and improved food security.Read moreRead less
Data-driven water quality treatment management decision support system. Data-driven water quality treatment management decision support system. This project aims to develop a robust decision support system to predict manganese and the character and concentration of dissolved organic matter in drinking water reservoirs, using intelligent algorithms and data collected through remote autonomous instrumentation. These predicted water quality parameters could be used as model input variables to provi ....Data-driven water quality treatment management decision support system. Data-driven water quality treatment management decision support system. This project aims to develop a robust decision support system to predict manganese and the character and concentration of dissolved organic matter in drinking water reservoirs, using intelligent algorithms and data collected through remote autonomous instrumentation. These predicted water quality parameters could be used as model input variables to provide real-time decisions for plant operators on the required treatment regime for incoming raw water, and advise them on the optimal reservoir offtake depth. This will potentially minimise treatment costs and health risks for consumers. The ultimate goal is to significantly enhance current water supply management practices.Read moreRead less