Psychiatric disorders are associated with considerable social and economic burden which could be reduced if we understood mental health outcomes in high risk populations. This fellowship will use advanced brain imaging to understand the development of mental health disorders in those at high risk of bipolar disorder and dementia.
Fellowship Application, Ed Stanley: Pluripotent Stem Cells & Medical Research
Funder
National Health and Medical Research Council
Funding Amount
$638,517.00
Summary
Human Pluripotent Stem Cells are immortal cells that have the ability to turn into any of the cell types found in the body. This means that it is now possible to generate a variety of human cell types in the laboratory, to study how they work, and to find out what goes wrong in different diseases. In this context, the overall aim of my research is to develop pluripotent stem cells for the study of human disease and generate tools that will enable others to use these cells in their own research.
Economic Evaluation Of Policies To Manage And Prevent Cardiovascular Disease & Diabetes In Australia
Funder
National Health and Medical Research Council
Funding Amount
$713,517.00
Summary
This Research Fellowship will use health economics to deliver health system impact. It will focus on: (i) mechanisms for setting prices for generic pharmaceuticals in Australia; (ii) exploring the implications for optimal prescribing from reductions in prices of pharmaceuticals to prevent cardiovascular disease and other chronic diseases; (iii) developing health economic computer simulation models to guide the prevention and treatment of diabetes and cardiovascular disease.
Understanding the immune response is proving extremely complex and promising results for disease treatments from animal models are often difficult to translate to new clinical therapies. My research is unearthing weaknesses in our current knowledge of the immune system and seeking to replace them with a foundation that can exploit new developments in computer modelling and systems biology. In this way I aim to rationally manipulate the immune response.
Understanding the immune response is proving extremely complex and promising results for disease treatments from animal models are often difficult to translate to new clinical therapies. My research is unearthing weaknesses in our current knowledge of the immune system and seeking to replace them with a foundation that can exploit new developments in computer modelling and systems biology. In this way I aim to rationally manipulate the immune response.
Regenerating The Kidney Using An Understanding Of Normal Development
Funder
National Health and Medical Research Council
Funding Amount
$951,005.00
Summary
In Australia, chronic kidney disease costs >$1 billion per annum, however treatment options for kidney failure have not changed for >50 years. Dialysis reduces quality of life and lifespan while only 1 in 4 patients receives a transplant. Using our understanding of normal kidney formation, this study will generate kidney tissue from human stem cells to better understand inherited kidney diseases and develop novel regenerative therapies for the treatment of end stage kidney disease.
Evaluations For Efficient And Effective Public Health Responses To HIV Epidemics
Funder
National Health and Medical Research Council
Funding Amount
$699,190.00
Summary
I will lead studies on evaluating population impact and calculating cost-effectiveness of public health prevention programs for HIV/AIDS epidemics in Asia and Eastern Europe. Return on Investment analyses will inform Ministries of Finance about overall budget allocations. Effectiveness and efficiency evaluations and determining optimal allocations of funding mixes will directly inform Ministries of Health in planning program implementation in 15-20 countries in the region.
Despite dramatic improvements in diagnosis, prevention and treatment of heart disease, cardiovascular disease remains the commonest cause of death in Australia. The continuing decline in mortality from ischaemic heart disease has been offset by an increase in the incidence of sudden cardiac death due to abnormal heart rhythms. By understanding the basic mechanisms underlying cardiac arrhythmias we are seeking to develop more effective therapies to treat and/or prevent sudden cardiac death.
Senior Research Fellowship In Lipoprotein Metabolism
Funder
National Health and Medical Research Council
Funding Amount
$804,106.00
Summary
A physiologist describing metabolic pathways and mechanisms that regulate lipoprotein metabolism in in vitro and in vivo systems. My research uses complex tracer studies and mathematical modelling to identify and quantitate pathways of lipid metabolism in normal and diseased states prior to and following lifestyle and/or pharmacological interventions. The focus of my research is on cardiovascular disease risk reduction.
Innovative Approaches To Reducing The Impact Of Blood Borne Viruses And Sexually Transmitted Infections On Young People.
Funder
National Health and Medical Research Council
Funding Amount
$246,859.00
Summary
Over the next 5 years I will undertake a program of research centred on reducing the impact of blood-borne viruses (BBVs) and sexually transmitted infections (STIs) in vulnerable populations, particularly young people. I will study how these infections are transmitted, associated risk behaviours including drug and alcohol use and sexual risk, and develop interventions to improve the detection and management of infected individuals.