Sewer corrosion reduction through model-supported ventilation control. Ventilation is one of the key technologies for sewer corrosion control. However, its design and operation are currently based on experience and empirical equations, often leading to unsatisfactory results. By integrating in-depth laboratory and pilot-sewer studies under defined conditions with extensive field investigations, this multidisciplinary project aims to develop critical models to predict the corrosion process in res ....Sewer corrosion reduction through model-supported ventilation control. Ventilation is one of the key technologies for sewer corrosion control. However, its design and operation are currently based on experience and empirical equations, often leading to unsatisfactory results. By integrating in-depth laboratory and pilot-sewer studies under defined conditions with extensive field investigations, this multidisciplinary project aims to develop critical models to predict the corrosion process in response to ventilation and dynamic wastewater and atmospheric conditions, enabling model-based sewer ventilation design and operation. The project also aims to deliver novel, field-demonstrated ventilation strategies. The project findings will be incorporated in the Australian ventilation design and operation guidelines.Read moreRead less
Microstructural-Functional Effect of Silver Diammine Fluoride on Apatites. This project aims to develop a fundamental understanding at the nanostructural level of the factors that contribute to the enhanced mineralisation and mechanical properties of dentine and enamel following the treatment with silver diammine fluoride (SDF). A variety of advanced nanomechanical, tomographic and microscopic techniques will be used to characterise sound, carious and SDF treated tissue. The new biomechanical ev ....Microstructural-Functional Effect of Silver Diammine Fluoride on Apatites. This project aims to develop a fundamental understanding at the nanostructural level of the factors that contribute to the enhanced mineralisation and mechanical properties of dentine and enamel following the treatment with silver diammine fluoride (SDF). A variety of advanced nanomechanical, tomographic and microscopic techniques will be used to characterise sound, carious and SDF treated tissue. The new biomechanical evidence on the underlying mechanisms, alternative protocols, delivery systems enable to optimise the treatment. The scientific insights into arresting/repairing damage processes will provide critical data for developing minimal intervention protocols for pediatric and geriatric populations.Read moreRead less
Engineering new tools to aid structure determination of membrane proteins. This project aims to address the inherent instability of G protein-coupled receptors (GPCRs), which are cell-surface proteins that are a major drug targets. The instability of GPCRs has resulted in a lack of atomic-level structural information that has hindered structure-based drug discovery efforts. This project expects to develop tools to improve GPCR stability and streamline the structure determination process. Project ....Engineering new tools to aid structure determination of membrane proteins. This project aims to address the inherent instability of G protein-coupled receptors (GPCRs), which are cell-surface proteins that are a major drug targets. The instability of GPCRs has resulted in a lack of atomic-level structural information that has hindered structure-based drug discovery efforts. This project expects to develop tools to improve GPCR stability and streamline the structure determination process. Project outcomes are intended to lead to significant advances in membrane protein structure determination and will have a substantial impact on future research in the pharmaceutical industry.Read moreRead less
Nanopore sensors for multiplexed, ultra-fast gene detection. The aim of this research is to develop the application of protein nanopores for multiplex identification of DNA samples for ultrafast gene detection. This is a type of barcoding of organism DNA that allows for rapid gene identification. This technology aims to address a significant need for rapid, on-the-spot identification of organisms. Applications include rapid identification of pathogenic bacteria in infections and identification o ....Nanopore sensors for multiplexed, ultra-fast gene detection. The aim of this research is to develop the application of protein nanopores for multiplex identification of DNA samples for ultrafast gene detection. This is a type of barcoding of organism DNA that allows for rapid gene identification. This technology aims to address a significant need for rapid, on-the-spot identification of organisms. Applications include rapid identification of pathogenic bacteria in infections and identification of organisms in environmental sampling. Current methods are relative slow, require DNA amplification and specialised laboratories.
This proposal aims to fine tune the properties of the large nanopore, polyC9, with respect to size and charge, as well as to identify and characterise novel large nanopores. Read moreRead less
Metal folding fundamentals to shape new corrugated building products . FormFlow has developed a ground-breaking forming process enabling the use of corrugated iron as a structural element. This is a step change for Australia`s steel and building industry and will provide a direct benefit to fireproofing homes. Up scaling of this new technology poses significant challenges due to the lack of understanding in the new forming process and the effect of pre-processing on the incoming material. Fundam ....Metal folding fundamentals to shape new corrugated building products . FormFlow has developed a ground-breaking forming process enabling the use of corrugated iron as a structural element. This is a step change for Australia`s steel and building industry and will provide a direct benefit to fireproofing homes. Up scaling of this new technology poses significant challenges due to the lack of understanding in the new forming process and the effect of pre-processing on the incoming material. Fundamental knowledge of material behaviour will be developed with advanced models that account for the unique process deformation conditions. The intended outcome includes computer software for process design and new concepts for part shape control to improve product quality, repeatability and enable high volume manufacture.Read moreRead less
Data-driven Traffic Analytics for Incident Analysis and Management. Traffic incidents are among the primary concerns of all transport authorities around the world due to their significant impact in terms of traffic congestion and delay, air and noise pollution, and management cost. This project aims to address incident analysis and management in complex and multi-modal traffic networks by combining multidisciplinary research efforts from transportation engineering and data science. The intended ....Data-driven Traffic Analytics for Incident Analysis and Management. Traffic incidents are among the primary concerns of all transport authorities around the world due to their significant impact in terms of traffic congestion and delay, air and noise pollution, and management cost. This project aims to address incident analysis and management in complex and multi-modal traffic networks by combining multidisciplinary research efforts from transportation engineering and data science. The intended outcomes will be an innovative incident analysis and management framework synergising traffic data analytics and traffic simulation modelling as well as its key enabling techniques and prototype systems. This will significantly help mitigate incident impacts on daily commuters.Read moreRead less
Smart Irrigation: integrating UAV soil moisture maps & variable rate sprays. This project will develop a state-of-the-art precision irrigation system for optimising water use and crop yield. Specifically, a novel UAV soil moisture mapping system based on passive microwave satellite remote sensing technology at L-band will be developed for near-surface soil moisture mapping at accuracies and spatial scales currently not attainable. These soil moisture maps will then be merged with irrigation wate ....Smart Irrigation: integrating UAV soil moisture maps & variable rate sprays. This project will develop a state-of-the-art precision irrigation system for optimising water use and crop yield. Specifically, a novel UAV soil moisture mapping system based on passive microwave satellite remote sensing technology at L-band will be developed for near-surface soil moisture mapping at accuracies and spatial scales currently not attainable. These soil moisture maps will then be merged with irrigation water delivery models to calibrate for spatial variation in soil properties and/or correct errors in spatial variation of rainfall and evapotranspiration inputs. Ultimately the water balance predictions will be used for implementation of variable rate irrigation control at scales hitherto unattainable.Read moreRead less
Robust, valid and interpretable deep learning for quantitative imaging. One of the biggest challenges in employing artificial intelligence is the “black-box” nature of the models used. This project aims to improve the effectiveness and trustworthiness of deep learning within quantitative magnetic resonance imaging. Deep learning has great promise in speeding-up complex image processing tasks, but currently suffers from variable data inputs, predictions are not guaranteed to be plausible and it i ....Robust, valid and interpretable deep learning for quantitative imaging. One of the biggest challenges in employing artificial intelligence is the “black-box” nature of the models used. This project aims to improve the effectiveness and trustworthiness of deep learning within quantitative magnetic resonance imaging. Deep learning has great promise in speeding-up complex image processing tasks, but currently suffers from variable data inputs, predictions are not guaranteed to be plausible and it is not clear to the end user how reliable the results are. The outcomes intend to deliver advanced knowledge and capability in artificial intelligence and machine learning that Australia urgently needs to capitalise on bringing deep learning into practical applications delivering economic, commercial and social impact.Read moreRead less
Investigating the atomic structure of an immune cell inhibitory receptor. T cells play a key role in the adaptive immune system, whose reactivity must be controlled to prevent aberrant reactivity. Central to the function of T cells is the T cell antigen receptor, and a host of co-stimulatory molecules, co-receptors and inhibitory receptors. This proposal, in partnership with Immutep Ltd, aims to gain a basic understanding of the structure and function of a key inhibitory receptor found on T cel ....Investigating the atomic structure of an immune cell inhibitory receptor. T cells play a key role in the adaptive immune system, whose reactivity must be controlled to prevent aberrant reactivity. Central to the function of T cells is the T cell antigen receptor, and a host of co-stimulatory molecules, co-receptors and inhibitory receptors. This proposal, in partnership with Immutep Ltd, aims to gain a basic understanding of the structure and function of a key inhibitory receptor found on T cells, termed the Lymphocyte activation gene-3 (LAG-3). The proposal utilises a combination of cellular immunology and structural biology to gain insight into the form and function of the LAG-3 molecule. Ultimately this fundamental knowledge can be used by the biotechnology industry.Read moreRead less
Integrated Farm Modelling to Improve Resilience and Sustainable Prosperity. This project aims to improve farm resilience, farm management, and economic decision-making in Australia and internationally. It expects to generate new interdisciplinary knowledge to integrate our understanding of agro-ecosystems and innovative tools to assess their status and manage their operations more effectively. Expected outcomes include the ability to inform farmers, bankers, and land managers about the trade-off ....Integrated Farm Modelling to Improve Resilience and Sustainable Prosperity. This project aims to improve farm resilience, farm management, and economic decision-making in Australia and internationally. It expects to generate new interdisciplinary knowledge to integrate our understanding of agro-ecosystems and innovative tools to assess their status and manage their operations more effectively. Expected outcomes include the ability to inform farmers, bankers, and land managers about the trade-offs between resilience and efficiency on farms. This should provide significant benefits, including the ability to minimize financial risks to farmers and banks, allow better investment decisions, and achieve sustainable long-term outcomes for both private and public well-being.Read moreRead less