Next generation dengue diagnostics. The 2009 dengue epidemic was widespread and the largest in North Queensland for 50 years. The outbreak was not quickly contained despite an extensive education program and a mosquito control taskforce. All four types of Dengue were detected, greatly increasing the chance of more severe complications such as Dengue haemorrhagic fever and Dengue shock syndrome. This project will improve our knowledge of Dengue proteins used in tests to diagnose the virus. The ne ....Next generation dengue diagnostics. The 2009 dengue epidemic was widespread and the largest in North Queensland for 50 years. The outbreak was not quickly contained despite an extensive education program and a mosquito control taskforce. All four types of Dengue were detected, greatly increasing the chance of more severe complications such as Dengue haemorrhagic fever and Dengue shock syndrome. This project will improve our knowledge of Dengue proteins used in tests to diagnose the virus. The new knowledge will be used to develop an easy to use test to diagnose Dengue infection early, rapidly and accurately. Effective diagnosis of Dengue will then allow timely implementation of intervention strategies (mosquito control, public advice, isolation and care).Read moreRead less
Modelling and control of mosquito-borne diseases in Darwin using long-term monitoring. Management of mosquito populations is a high public health priority because these insects can spread diseases such as malaria, dengue, Ross River virus, Barmah Forest virus, Murray Valley encephalitis, Japanese encephalitis and Kunjin/West Nile virus. Our research into the effectiveness of mosquito control programs in Darwin is of immediate national relevance and priority given the need to Safeguard Australia ....Modelling and control of mosquito-borne diseases in Darwin using long-term monitoring. Management of mosquito populations is a high public health priority because these insects can spread diseases such as malaria, dengue, Ross River virus, Barmah Forest virus, Murray Valley encephalitis, Japanese encephalitis and Kunjin/West Nile virus. Our research into the effectiveness of mosquito control programs in Darwin is of immediate national relevance and priority given the need to Safeguard Australia from invasive diseases. There is an urgency to undertake our research because global environmental change and increasing movements of people (particularly military personnel) from overseas regions where these diseases are endemic is increasing the vulnerability of northern Australia to the (re)establishment of mosquito borne diseases.Read moreRead less
Threats of avian pathogens to endangered parrots and human health: developing and utilizing tools for risk reduction. Emerging infectious diseases (EID) are among the most significant threats to conservation, agriculture and public health worldwide. Among these are two globally significant avian pathogens, Chlamydia psittaci and Beak and Feather Disease Virus. This project aims to determine transmission dynamics, fitness costs of infection, and quantify the roles of genetic diversity and host st ....Threats of avian pathogens to endangered parrots and human health: developing and utilizing tools for risk reduction. Emerging infectious diseases (EID) are among the most significant threats to conservation, agriculture and public health worldwide. Among these are two globally significant avian pathogens, Chlamydia psittaci and Beak and Feather Disease Virus. This project aims to determine transmission dynamics, fitness costs of infection, and quantify the roles of genetic diversity and host stress in infection and disease emergence. The project aims to also determine to what extent zoonotic poultry/human infection is related to infection in wild birds. The outcomes aim to be the development of critical knowledge and tools to help manage two avian pathogens causing significant conservation, agricultural and public health concern around the world.Read moreRead less
Understanding the control of adult mosquitoes to reduce arbovirus transmission while minimising environmental and public health risk. Mosquitoes are capable of transmitting a wide range of debilitating diseases such as Ross River and Barmah Forest viruses, Murray Valley Encephalitis, Japanese Encephalitis, Dengue fever and Malaria. To prevent the transmission of these diseases local authorities expend considerable resources on the control of mosquitoes. This project will increase the understan ....Understanding the control of adult mosquitoes to reduce arbovirus transmission while minimising environmental and public health risk. Mosquitoes are capable of transmitting a wide range of debilitating diseases such as Ross River and Barmah Forest viruses, Murray Valley Encephalitis, Japanese Encephalitis, Dengue fever and Malaria. To prevent the transmission of these diseases local authorities expend considerable resources on the control of mosquitoes. This project will increase the understanding of chemical control measures on adult mosquitoes and this will lead to more effective mosquito control treatments and reduce the incidence of mosquito transmitted diseases. The project will also result in a reduction in the risk from the application of pesticide to public health and the environment.Read moreRead less
Modelling and Simulation of Disease Spread Dynamics Using Interacting Automata. Modelling and simulation techniques will be developed to strengthen our understanding of disease spread over the landscape, so allowing timely control strategies to be developed. The economic cost to Australia of introduced pests, animal and plant diseases is considerable. We utilise an interacting automata formalism to capture landscape, population and contagion information as it affects disease spread to provide ....Modelling and Simulation of Disease Spread Dynamics Using Interacting Automata. Modelling and simulation techniques will be developed to strengthen our understanding of disease spread over the landscape, so allowing timely control strategies to be developed. The economic cost to Australia of introduced pests, animal and plant diseases is considerable. We utilise an interacting automata formalism to capture landscape, population and contagion information as it affects disease spread to provide more accurate simulation than is done at present. Generic simulation tools will be constructed, capable of being rapidly personalised by epidemiologists for specific diseases.Read moreRead less
Genome-wide determination of Puccinia psidii s.l. rust resistance in eucalypts. Recently, guava rust was detected in Australia, posing significant risks to native flora, plantations, and timber exports. Scientists from The University of Melbourne and Victorian Department of Primary Industries together with tree breeders, forest growers and forest managers aim to use tree genomics rust resistance breeding to enable management and operational responses and inform policy development.
Sexual health promotion in Papua New Guinea: a community capacity-building approach using drama-based experiential learning methods. The Australian government is committed to developing a secure and prosperous Papua New Guinea. A major constraint to PNG's prosperity is the HIV/AIDS epidemic, fuelled by a generalised Sexually Transmitted Infection (STI) epidemic. This project will build the capacity of local PNG personnel to implement, evaluate, and further develop, effective interventions based ....Sexual health promotion in Papua New Guinea: a community capacity-building approach using drama-based experiential learning methods. The Australian government is committed to developing a secure and prosperous Papua New Guinea. A major constraint to PNG's prosperity is the HIV/AIDS epidemic, fuelled by a generalised Sexually Transmitted Infection (STI) epidemic. This project will build the capacity of local PNG personnel to implement, evaluate, and further develop, effective interventions based on established experiential learning modalities. Learnings from this landmark study will also provide vital information for policy makers and funding bodies in Australia and other nations, to establish more effective strategies for improving the health and wellbeing of young people and preventing the spread of STIs and HIV/AIDS.Read moreRead less
Synthesis and Performance of Novel Polymer Resists for 193 nm Immersion Lithography. The semiconductor industry is one of the largest world-wide, with annual revenue of $217B and employing over 1.5M people around the world. This project provides a unique opportunity for development within Australia of significant expertise in the field of polymers for short-wavelength lithography. The materials to be developed are expected to provide the basis of future genertions of microchips. In addition the ....Synthesis and Performance of Novel Polymer Resists for 193 nm Immersion Lithography. The semiconductor industry is one of the largest world-wide, with annual revenue of $217B and employing over 1.5M people around the world. This project provides a unique opportunity for development within Australia of significant expertise in the field of polymers for short-wavelength lithography. The materials to be developed are expected to provide the basis of future genertions of microchips. In addition the materials have applications in other technologies which are manufactured in Australia, for example in spectactle lenses and optical fibres. A major outcome of this project will be establishment of Australia as a world-leader in this rapidly expanding field.Read moreRead less
Exploiting subterranean clover genetic variation for methane mitigation and ruminant health challenges to the Australian livestock industries. Subterranean clover is the most widely sown annual pasture legume species in southern Australia. It is native to the Mediterranean basin and has been sown over an estimated area of 22 million hectares. This project will provide breeders with a genomic resource for future breeding programs focused on methane emission mitigation and ruminant health. The foc ....Exploiting subterranean clover genetic variation for methane mitigation and ruminant health challenges to the Australian livestock industries. Subterranean clover is the most widely sown annual pasture legume species in southern Australia. It is native to the Mediterranean basin and has been sown over an estimated area of 22 million hectares. This project will provide breeders with a genomic resource for future breeding programs focused on methane emission mitigation and ruminant health. The focused marker assisted breeding will lead to more efficient and effective breeding of elite cultivars for sustainable and profitable farming systems to benefit the wool and meat industries. Low methanogenic pastures with low isoflavone content offer an exciting avenue for agriculture to reduce its carbon footprint whilst maintaining or improving profitability.Read moreRead less
Between a hot place & hypoxia: Quantifying fish-kill risk in inland rivers. Native fish populations in Australian ephemeral rivers are highly valued but are subject to widespread decline. During drought waterholes serve as critical refuges for native fish, however thermal extremes and hypoxia (lack of oxygen) have led to regular fish-kill events. Whilst we know the general conditions that lead to fish-kills, we do not have a clear understanding of why some species are more tolerant than others, ....Between a hot place & hypoxia: Quantifying fish-kill risk in inland rivers. Native fish populations in Australian ephemeral rivers are highly valued but are subject to widespread decline. During drought waterholes serve as critical refuges for native fish, however thermal extremes and hypoxia (lack of oxygen) have led to regular fish-kill events. Whilst we know the general conditions that lead to fish-kills, we do not have a clear understanding of why some species are more tolerant than others, or how we can help decision-makers anticipate fish-kill risks. This project will combine laboratory ecophysiology investigations and novel field monitoring techniques to develop a next-generation fish habitat model for stakeholders to use to assess fish-kill risks and plan for restoration. Read moreRead less