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Characterising post-translational modifications in bacterial proteins. This project represents the first global attempt to characterize post-translational modifications in bacterial proteins using the tools of proteomics. Modifications to proteins are key elements in altering their function. In bacteria, modifications are important in cell-cell adhesion, signalling and triggering of the immune response. Characterisation of modified proteins and their sites of modification represents an opportuni ....Characterising post-translational modifications in bacterial proteins. This project represents the first global attempt to characterize post-translational modifications in bacterial proteins using the tools of proteomics. Modifications to proteins are key elements in altering their function. In bacteria, modifications are important in cell-cell adhesion, signalling and triggering of the immune response. Characterisation of modified proteins and their sites of modification represents an opportunity to understand how bacterial cell populations communicate in the environment, as well as aid in understanding pathogenesis in medical, veterinary and food-borne pathogens. Therefore, improved vaccine targets and therapeutics, as well as method-based products, may be generated by this project.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775612
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
Nanomaterials Optical Characterisation Facility. Nanotechnology is expected to revolutionize a wide variety of fields, from medicine to agriculture, communications and electronics. However, the small length scales involved present significant challenges with regard to characterising the nanomaterials produced. The Nanomaterials Optical Characterisation facility will provide state-of-the-art equipment for examining the properties of nanomaterials. The equipment will be pivotal in assisting the de ....Nanomaterials Optical Characterisation Facility. Nanotechnology is expected to revolutionize a wide variety of fields, from medicine to agriculture, communications and electronics. However, the small length scales involved present significant challenges with regard to characterising the nanomaterials produced. The Nanomaterials Optical Characterisation facility will provide state-of-the-art equipment for examining the properties of nanomaterials. The equipment will be pivotal in assisting the development of next-generation medicines, implants, optical devices and surface coatings, further strengthening Australia's formidable reputation in these areas.Read moreRead less
Terahertz Spectroscopy of Mass-Manufactured Viral Vaccines. The breakthrough vaccine for cervical cancer proves that new and exciting products are on the way to treat and protect against previously untouchable diseases. Similar products for bird flu are being researched, and new manufacturing methods are urgently needed to get this science to market at a price that people can afford. However, manufacturing innovation in the pharmaceutical industry is constrained by a lack of methods for product ....Terahertz Spectroscopy of Mass-Manufactured Viral Vaccines. The breakthrough vaccine for cervical cancer proves that new and exciting products are on the way to treat and protect against previously untouchable diseases. Similar products for bird flu are being researched, and new manufacturing methods are urgently needed to get this science to market at a price that people can afford. However, manufacturing innovation in the pharmaceutical industry is constrained by a lack of methods for product analysis. In this project engineers will devise advanced methods to fingerprint these new vaccine products, ensuring that manufacturing processes can be improved without compromising safety. These new analytical techniques will potentially lead to new low-cost vaccine products made in Australia.Read moreRead less