Scaling-up microfluidic drying as an efficient route to manufacture uniform and functional particles as high-value products. This project aims to scale-up microfluidic spray drying and demonstrate the method as a viable option to manufacture monodisperse microparticles as bioactive carriers or microencapsulates, with better functional properties and uniformity. It aims to transform the manufacturing of high-value products for pharmaceuticals, functional foods and biotechnology applications and l ....Scaling-up microfluidic drying as an efficient route to manufacture uniform and functional particles as high-value products. This project aims to scale-up microfluidic spray drying and demonstrate the method as a viable option to manufacture monodisperse microparticles as bioactive carriers or microencapsulates, with better functional properties and uniformity. It aims to transform the manufacturing of high-value products for pharmaceuticals, functional foods and biotechnology applications and lift productivity by managing innovation for Australia’s industries.Read moreRead less
Breakthrough technologies for energy-efficient manufacture of dairy powders. The outcomes of this project will form a significant change for the dairy industry in Australia (as represented by Dairy Innovation Australia Ltd.). In particular, the enormous cost-saving and environmental benefits due to a more efficient drying process are attractive for the competitiveness of the industry internationally. The innovation gained is also applicable to food and pharmaceutical industries where spray dryin ....Breakthrough technologies for energy-efficient manufacture of dairy powders. The outcomes of this project will form a significant change for the dairy industry in Australia (as represented by Dairy Innovation Australia Ltd.). In particular, the enormous cost-saving and environmental benefits due to a more efficient drying process are attractive for the competitiveness of the industry internationally. The innovation gained is also applicable to food and pharmaceutical industries where spray drying and fluidised bed drying are integral parts of the manufacturing process. The project will train graduates to be able to make a high-level contribution to these industries.Read moreRead less
Immune-imprinting nanoparticles (iNPs). This research promises new classes of immune-imprinting, biodegradable nanoparticles (iNPs) with anti-inflammatory properties. The engineering of such particles requires fundamental understanding of their properties that enable specific cellular interactions to regulate immunity with new anti-inflammatory pathways. For pulmonary delivery, spray-dried amino acid microspheres with tailored surfaces as carriers can be generated using the innovative microfluid ....Immune-imprinting nanoparticles (iNPs). This research promises new classes of immune-imprinting, biodegradable nanoparticles (iNPs) with anti-inflammatory properties. The engineering of such particles requires fundamental understanding of their properties that enable specific cellular interactions to regulate immunity with new anti-inflammatory pathways. For pulmonary delivery, spray-dried amino acid microspheres with tailored surfaces as carriers can be generated using the innovative microfluidic drying approach. The potential applications of iNPs are wide-ranging and are not restricted to pulmonary targeting. The potential commercial implications for Australia's emerging biopharmaceutical industry are substantial.Read moreRead less
Predictive Tools for Effective Spray Drying of Heat Sensitive Dairy Powders. This project is a joint international effort between Monash University, the Institute of Dairy Ingredients Processing at South Dakota State University, and the Dairy Research Institute to address challenges in achieving optimum spray drying conditions for heat sensitive dairy powders, such as milk protein concentrates and whey powders. The new modelling tool aims to help in predicting effective spray drying conditions t ....Predictive Tools for Effective Spray Drying of Heat Sensitive Dairy Powders. This project is a joint international effort between Monash University, the Institute of Dairy Ingredients Processing at South Dakota State University, and the Dairy Research Institute to address challenges in achieving optimum spray drying conditions for heat sensitive dairy powders, such as milk protein concentrates and whey powders. The new modelling tool aims to help in predicting effective spray drying conditions to produce powders with improved solubility, emulsification, and heat stability properties. It is expected that the dairy industry will benefit from the use of this technology to deliver milk powders with improved quality, functionality, and shelf-life.Read moreRead less
High value micron-sized particles from a novel antisolvent vapour spray drying system. Convective antisolvent precipitation is a novel route in producing particles from spray drying by adding an anti-solvent to the drying medium. This project will allow conventional spray dryers to produce more sophisticated ultrafine and encapsulated particles for use in food, pharmaceuticals and other high value applications.
Powder blending for dry powder inhalers: a new approach for direct control of powder structure. Over 80 per cent of pharmaceutical products involve the processing of powders. This project will generate new knowledge of how to assemble fine and cohesive particles into the structure required for dry powder inhaler products, leading to the development of new low-cost medicines in Australia and the Asia Pacific region.
Micromechanical analysis of size segregation and its prediction in granular free-surface flows. Industries often suffer from size segregation in the handling and processing of granular materials, leading to significant economic consequences. This project aims to develop a fundamental understanding of size segregation and prediction models, enabling industries to eliminate, minimise, or manage the effects to an acceptable level.
Discovery Early Career Researcher Award - Grant ID: DE140101759
Funder
Australian Research Council
Funding Amount
$385,720.00
Summary
A novel fundamental approach to enable net shape manufacturing of low-cost high-performance titanium alloys . Oxygen is the bottleneck issue of titanium powder metallurgy, which radically deteriorates the ductility of titanium. This project aims to develop the essential fundamental knowledge and technical solutions to mitigate the detrimental effect of oxygen on the ductility of as-sintered titanium products and enable the net-shape fabrication of low-cost high-performance titanium alloys. This ....A novel fundamental approach to enable net shape manufacturing of low-cost high-performance titanium alloys . Oxygen is the bottleneck issue of titanium powder metallurgy, which radically deteriorates the ductility of titanium. This project aims to develop the essential fundamental knowledge and technical solutions to mitigate the detrimental effect of oxygen on the ductility of as-sintered titanium products and enable the net-shape fabrication of low-cost high-performance titanium alloys. This will be achieved by utilising the inexpensive and unique titanium hydride powder, rather than titanium metal powder, and by developing effective oxygen scavengers. The outcomes will form a robust basis for the creation of a viable titanium hydride powder metallurgy business.Read moreRead less
Perfect particles: Accurate breakage predictions by 3D printing of granules. Granule breakage of micro-structured specialty products impedes manufacturing and degrades product performance. Predictive breakage models have had limited success as each granule has a unique structure. Differences between the model predictions and experimental breakage test results could be due to inaccurate models or irreproducible experimental results due to granule structure differences. This project is expected to ....Perfect particles: Accurate breakage predictions by 3D printing of granules. Granule breakage of micro-structured specialty products impedes manufacturing and degrades product performance. Predictive breakage models have had limited success as each granule has a unique structure. Differences between the model predictions and experimental breakage test results could be due to inaccurate models or irreproducible experimental results due to granule structure differences. This project is expected to be the first ever application of three-dimensional printing for reproducible breakage testing. The project aims to: create the first ever multiple identical copies of complex granules using polyjet three-dimensional printing; model and experimentally measure granule breakage; and develop sophisticated Digital Elevation Models of granule breakage for practical use in industry.Read moreRead less
Particle scale modelling and analysis of the multiphase flows in coal preparation. Australia is the world's biggest coal exporter, and black coal is Australia's largest export, with an annual value >$20 billion. Optimum design and control of the processes in coal preparation play a critical economic role in coal production. This project aims at providing substantial improvements through the application of a novel combined continuum and discrete modelling method. Specifically, the improvements ta ....Particle scale modelling and analysis of the multiphase flows in coal preparation. Australia is the world's biggest coal exporter, and black coal is Australia's largest export, with an annual value >$20 billion. Optimum design and control of the processes in coal preparation play a critical economic role in coal production. This project aims at providing substantial improvements through the application of a novel combined continuum and discrete modelling method. Specifically, the improvements targeted relate to better process and product control, a decrease in unit energy consumption and improvements in productivity, which, together with the research training offered, will further enhance Australia's leading position in global coal industry.Read moreRead less