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Assessment Of Calcium Signaling In Breast Cancer Cells Associated With Epithelial-mesenchymal Transition
Funder
National Health and Medical Research Council
Funding Amount
$116,762.00
Summary
This research will assess the role of specific proteins that control cell function in a process which is important in the spread of cancer cells throughout the body. The work is aimed at identifying new targets for drugs that may be used to prevent or stop the spread of breast cancer cells to other organs such as the brain and liver.
Open-label Randomised Trial Of Tolvaptan Versus Fluid Restriction In Hospitalised Patients With Moderate-severe Hyponatraemia
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
Low blood sodium level, known as hyponatraemia, is the most common electrolyte problem. It occurs in 15% of hospital patients, and can cause confusion, seizure and fatal brain swelling. Standard treatment for hyponatraemia is limiting oral fluid, but this is slow and not always effective. The drug tolvaptan works in mild hyponatraemia, but hasn't been formally tested in severe cases. We will compare benefits and risks of tolvaptan versus fluid restriction in patients with severe hyponatremia.
The Capacity Of Non-government Organisations To Improve The Food Supply
Funder
National Health and Medical Research Council
Funding Amount
$76,123.00
Summary
Reducing premature death from cardiovascular disease is a health priority and reducing dietary salt is vital to achieve this. Most dietary salt is in processed foods and non-government organisations (NGOs) have long advocated for less salty foods. Little is known about why some companies sell very salty foods compared to others. This research considers the influence of NGOs on the behaviour of food companies and the respective reformulation strategies, and seeks to find out why companies respond ....Reducing premature death from cardiovascular disease is a health priority and reducing dietary salt is vital to achieve this. Most dietary salt is in processed foods and non-government organisations (NGOs) have long advocated for less salty foods. Little is known about why some companies sell very salty foods compared to others. This research considers the influence of NGOs on the behaviour of food companies and the respective reformulation strategies, and seeks to find out why companies respond differently.Read moreRead less
Early Detection Of Coronary Artery Disease: An Opportunity To Start Secondary Prevention Without A Coronary Event
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
Coronary artery disease (CAD) is a major cause of death and disability in Australia, and prevention is key. Our current techniques for predicting who is at high risk of CAD are imperfect or expensive. We aim to study how using the combination of a genetic and metabolic risk score can be used to cost-effectively predict this risk more accurately. By doing so, we aim to develop a new combined test to identify Australians at high risk of CAD so that prevention can be started early.
The Biophysical Basis Of HCN Channels In Human Peripheral Nerve
Funder
National Health and Medical Research Council
Funding Amount
$50,315.00
Summary
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play an important role as pacemakers in the cardiac and nervous systems. HCN channel dysfunction is implicated in a number of disorders including neuropathic pain and epilepsy. My aim is to determine the kinetics and voltage dependence of HCN channels in human peripheral nerve in vivo. Understanding these channels is a prerequisite to the development of safe targeted therapies against neuropathic pain.
Parathyroid Hormone-related Protein (PTHrP), Common Genetic Variants In The PTHrP Gene (PTHLH), And Breast Cancer Risk And Survival
Funder
National Health and Medical Research Council
Funding Amount
$120,253.00
Summary
In a partnership between Peter MacCallum Cancer Centre, St Vincent's Hospital, and The University of Melbourne, we are investigating the role of PTHrP, a peptide integral to the growth and spread of Cancer. Initially thought to facilitate cancer spread, recent studies suggest it may actually be protective. In a new approach, we will analyse new DNA databases and patient data from around the world. We hope to extend our understanding of PTHrP, and perhaps find novel drug and therapeutic targets.
Improving Health Services Around The Time Of Childbirth In Places Where Death Rates Are High And Home-births Common
Funder
National Health and Medical Research Council
Funding Amount
$119,335.00
Summary
In settings close to Australia where death rates among mothers and newborns remain high, it is common for childbirth to take place outside of health facilities. This research will develop feasible options for countries aiming to simultaneously improve care in first-line health facilities (which often takes some years), and simultaneously provide some limited services in the home that can reduce deaths immediately.
Understanding Current And Future Opportunities To Promote Healthy Maternal Weight During Pregnancy And The Postpartum Period
Funder
National Health and Medical Research Council
Funding Amount
$75,620.00
Summary
The PhD will document clinical management of maternal weight gain during and post pregnancy, across a range of antenatal care providers and deliver a nine month pilot intervention study for first time mothers, aimed at reducing post pregnancy weight retention and promoting healthy nutrition and physical activity behaviours. Findings from this PhD will inform important future development of healthy weight interventions across the reproductive years.
The Impact Of Infections, Anaemia, And Micronutrient Deficiencies On Infant Birth Weight And Growth
Funder
National Health and Medical Research Council
Funding Amount
$83,613.00
Summary
This research aims to determine the impact of infectious diseases, anemia and nutritional deficiencies on low birth weight and infant growth in rural Papua New Guinea. The health of pregnant women and their babies will be assessed during pregnancy and up to 12 months post birth. We will determine which health indicators cause low birth weight and poor infant growth to enable development of interventions to improve health and pregnancy outcomes.
Measuring Hypoxia Induced MRNA In Maternal Blood To Determine Acidaemic Status Of Growth Restricted Fetuses In Utero
Funder
National Health and Medical Research Council
Funding Amount
$120,253.00
Summary
Small babies are at greater risk of dying while inside their mothers and the right time to deliver them is an obstetric conundrum. Currently obstetricians rely on ultrasound measures of the baby's wellbeing which do not always correspond with how sick the baby truly is. There is a great need for a more accurate test. This research intends to show that a blood test from the mother can more accurately tell how sick the baby is and provide an answer to when is the best time to deliver the baby.