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Pulmonary Artery Pulsatility As A Predictor Of Survival Following Hospitalized Exacerbation Of Chronic Obstructive Pulmonary Disease
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Many patients with Chronic Obstructive Pulmonary Disease (COPD) also have elevated lung blood pressures, or pulmonary hypertension (PH). Having both conditions increases the risk of death. It is difficult to diagnose PH in COPD. We will be using a new Computed Tomography (X-ray imaging) technique to investigate a marker of PH called ‘pulmonary artery pulsatility’. If PH can be diagnosed easily and accurately new treatments can be devised and researched potentially improving outcomes in COPD.
This Practitioner Fellowship will aim to improve outcomes in people with lung cancer. The clinical studies will focus on: 1. Using low dose CT scans to detect lung cancer at a very early stage. 2. Molecular tests to diagnose lung cancer earlier, and provide information that will be useful for deciding treatment 3. Using advanced techniques to diagnose small opacities in the lung
Airway Wall Thickness And Heterogeneity Are Key Determinants Of Asthmatic Airway Function.
Funder
National Health and Medical Research Council
Funding Amount
$207,509.00
Summary
Asthma is a common disease which is typified by excessive narrowing of the airways in response to stimuli that are trivial to non-asthmatic individuals. However, little is known about what causes asthmatic airways to be able to narrow so excessively. In this study, we will be looking at the importance of thickening of the airway walls in relation to excessive airway narrowing in asthmatics. We will also look to see how patchy the airway narrowing is in asthmatics and how this relates to excessiv ....Asthma is a common disease which is typified by excessive narrowing of the airways in response to stimuli that are trivial to non-asthmatic individuals. However, little is known about what causes asthmatic airways to be able to narrow so excessively. In this study, we will be looking at the importance of thickening of the airway walls in relation to excessive airway narrowing in asthmatics. We will also look to see how patchy the airway narrowing is in asthmatics and how this relates to excessive airway narrowing that occurs in severe asthmatic attacks. We will therefore be studying asthmatics of varying degrees of disease severity as well as those admitted to hospital because of acute severe attacks of asthma, and comparing them with a group of non-asthmatic subjects.Read moreRead less
A Multi-centre, Randomised, Controlled Trial Of BAL Directed Therapy In Young Children With Cystic Fibrosis.
Funder
National Health and Medical Research Council
Funding Amount
$571,750.00
Summary
The management of children with cystic fibrosis (CF) aims to delay the inevitable progression of lung disease that results from chronic lower respiratory tract infection (LRTI) and inflammation. Flexible bronchoscopy (FB) and bronchoalveolar lavage (BAL) are increasingly used as research and clinical tools in the management of LRTI in CF infants and are integral to the monitoring of future drug trials and gene therapy. Early LRTI particularly with Pseudomonas aeruginosa (Pa) in CF is associated ....The management of children with cystic fibrosis (CF) aims to delay the inevitable progression of lung disease that results from chronic lower respiratory tract infection (LRTI) and inflammation. Flexible bronchoscopy (FB) and bronchoalveolar lavage (BAL) are increasingly used as research and clinical tools in the management of LRTI in CF infants and are integral to the monitoring of future drug trials and gene therapy. Early LRTI particularly with Pseudomonas aeruginosa (Pa) in CF is associated with a decline in pulmonary function and an increase in morbidity and mortality. Many CF centres internationally now treat young children with CF using aggressive antibiotic protocols in an attempt to eradicate infection. Most centres use oropharyngeal specimens to diagnose LRTI with a sensitivity of around 45% and specificity of around 90%. Thus many children miss out on treatment or are exposed unnecessarily to antibiotics. The use of antibiotics themselves may increase the risk of infection with resistant organisms thus complicating the design of drug trials in young children as monitoring for the emergence of resistant new organisms requires BAL. It is thus of key importance that the safety and value of FB and BAL is examined and long term outcomes are obtained. The financial costs of managing patients with CF in Australia may be estimated at more than $85 million-annum. Early intervention strategies may reduce health costs because of improved morbidity or may increase costs due to the intervention. This will be the first time an economic evaluation of early management and the cost effectiveness of an intervention in children with CF has been undertaken which will enable responsible health care planning for this important group of patients. This trial provides a unique opportunity to study the relationship between LRTI and inflammation and long term outcomes such as lung function and radiological scores and will provide key evidence for designing future trials.Read moreRead less
Bronchoscopic Applications Of Anatomical Optical Coherence Tomography.
Funder
National Health and Medical Research Council
Funding Amount
$408,366.00
Summary
This research proposal aims to investigate the potential utility of a novel, Australian designed dianostic laser system. A tube positioned in the lungs takes real-time images of the shape and size inside the airways. This can have both clinical and research benefits. It may help doctors choose the right size hardware when opening up cancerous airways and it will help us understand disease mechanisms of lung diseases by studying parts of the airways not previously able to be measured.