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The Use Of Positron Emission Tomography (PET), Novel Immune And Microbiological Biomarkers To Improve The Diagnosis And Prognostication Of Giant Cell Arteritis
Funder
National Health and Medical Research Council
Funding Amount
$124,676.00
Summary
Giant cell arteritis (GCA) is an inflammatory condition of blood vessels. Diagnosing the condition and predicting which patients will develop complications is challenging. Undiagnosed, a significant proportion of patients experience sudden onset, permanent blindness. Our study aims to improve the diagnosis and risk assessment of patients with suspected GCA by following a group of 65 patients for two years with serial scans, blood tests and clinical reviews.
Prospective Clinical Research Of Radiation Response To High-dose Radiotherapy In Lung Tumours And Surrounding Normal Tissue Using Functional Imaging Biomarker Assessments
Funder
National Health and Medical Research Council
Funding Amount
$120,275.00
Summary
Radiotherapy is a potentially curative treatment for cancers of the lung. To improve outcomes, modern research efforts have focussed on radiotherapy dose escalation. However a major limitation to dose escalation is the associated toxicity to the lung. At present, the mechanisms of lung toxicity are incompletely understood. This research will investigate biomarkers of radiation response in patients receiving high-dose radiotherapy to the lung by using state-of-the-art scanning techniques.
The Distribution And Spread Of Motor System Dysfunction In Early Motor Neurone Disease.
Funder
National Health and Medical Research Council
Funding Amount
$107,287.00
Summary
At present, motor neurone disease remains an incurable, fatal neurodegenerative condition with few disease-modifying treatments. There is ongoing uncertainty around the mechanisms of onset and disease propagation. This research aims to clarify the onset and pathophysiological mechanisms of motor neurone disease using novel neurophysiological and neuroimaging techniques, the results of which will contribute to the search for early diagnositc markers and new treatments.
The Effect Of Statin And Colchicine On Pericoronary Adipose Tissue Inflammation And Coronary Artery Plaque Progression: Insights From Cardiac Computed Tomography Using Pericoronary Adipose Tissue Attenuation And Radiomics
Funder
National Health and Medical Research Council
Funding Amount
$125,396.00
Summary
Coronary artery disease is the leading cause of death in Australia. Inflammation is a key driver of harmful build-up of cholesterol plaques in arteries. Currently it is unclear how to detect patients with high level of inflammation. We examine a new approach to detect coronary inflammation using CT coronary angiography (CTCA). We investigate how to utilise CTCA to guide targeted therapy with statin and colchicine in patients with residual inflammation to reduce risk of future heart attack.
CompUted Tomography Coronary Angiography, Transthoracic Echocardiography AnD Assessment Of AssOciation Between Obesity, Weight ReductioN And Coronary Plaque (CUTDOWN)
Funder
National Health and Medical Research Council
Funding Amount
$122,714.00
Summary
Obesity is a major risk factor for cardiovascular disease and death. This project will investigate the links between obesity, heart attacks and abnormal heart function and the impact of weight loss on these detrimental effects in patients who have had a heart attack. This research aims to better understand mechanisms that may prevent future heart attacks and improve heart function.
Risk Stratification And Early Interventions In Pulmonary Vascular Disease: From Acute Pulmonary Embolisms To Chronic Pulmonary Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$99,682.00
Summary
Pulmonary embolism (PE) is a common, potentially life-threatening condition with up to 50% of survivors developing long-term complications, which are associated with breathlessness, functional limitation and risk of premature death if not diagnosed and treated promptly. This project investigates the use of non-invasive scan techniques and exercise testing for early detection of these complications. The project will also explore new drug targets to treat these complications.
The Influence Of Transcatheter Aortic Valve Implantation On Myocardial Structure And Function
Funder
National Health and Medical Research Council
Funding Amount
$110,218.00
Summary
Transcatheter aortic valve implantation has given options to elderly patients who were previously faced with an open-heart operation. Our research utilises CT scans to determine the anatomical and physiological effects this new technology has on the heart. This research will help to guide the ongoing development and refinement of this technology. The research has the potential to revolutionise how aortic stenosis is assessed and timing of intervention is determined.
Pulmonary Artery Pulsatility As A Predictor Of Survival Following Hospitalized Exacerbation Of Chronic Obstructive Pulmonary Disease
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Many patients with Chronic Obstructive Pulmonary Disease (COPD) also have elevated lung blood pressures, or pulmonary hypertension (PH). Having both conditions increases the risk of death. It is difficult to diagnose PH in COPD. We will be using a new Computed Tomography (X-ray imaging) technique to investigate a marker of PH called ‘pulmonary artery pulsatility’. If PH can be diagnosed easily and accurately new treatments can be devised and researched potentially improving outcomes in COPD.
Validation Of Point Of CarE CT DeRived FracTionAl Flow Reserve In Stable Coronary Artery Disease (VERITAS)
Funder
National Health and Medical Research Council
Funding Amount
$78,554.00
Summary
In stable coronary artery disease outcomes are dependent on the presence and burden of ischaemia. Current methods of assessing ischaemia are either invasive with associated risks or non-invasive but limited in their diagnostic accuracy. Our research plans to assess the real world feasibility of a novel, non-invasive, point of care CT-Derived Fractional Flow Reserve technique and its potential for guiding clinical decision making and influencing downstream testing.