Child Health And Development: A South Australian Data Linkage Study
Funder
National Health and Medical Research Council
Funding Amount
$283,934.00
Summary
Children’s healthy development is important for their readiness to learn, academic achievement at school, and for their future health and economic capability. This study links whole-of-population administrative data from nine different government sources, and data collected as part of a natural experiment evaluating the effects of the South Australian Family Home Visiting program to inform policy and service delivery in child health and development in South Australia.
Centre Of Clinical Research Excellence In Aboriginal Health
Funder
National Health and Medical Research Council
Funding Amount
$1,899,510.00
Summary
The Centre's mission is to improve Aboriginal health. It will conduct Aboriginal community-controlled population health and outcome-oriented research on strategies and systems that support individuals and communities to prevent and manage chronic diseases. The Centre will provide a range of research and other training opportunities for Aboriginal people, building the capacity of Aboriginal communities to direct and conduct their own health research independently. The Centre will be led by the Ab ....The Centre's mission is to improve Aboriginal health. It will conduct Aboriginal community-controlled population health and outcome-oriented research on strategies and systems that support individuals and communities to prevent and manage chronic diseases. The Centre will provide a range of research and other training opportunities for Aboriginal people, building the capacity of Aboriginal communities to direct and conduct their own health research independently. The Centre will be led by the Aboriginal Health Council of South Australia in partnership with Flinders University.Read moreRead less
Diet influences the selective advantage of mitochondrial DNA mutations. This project aims to examine critical mechanisms that affect mitochondrial DNA variation within species. It aims to test the hypothesis that mitochondrial DNA haplotypes have the potential to be under nutritionally induced balancing selection as a consequence of cellular signalling and/or Adenosine triphosphate (ATP) production by mitochondria. Diet can vary both seasonally and geographically and is a key environmental param ....Diet influences the selective advantage of mitochondrial DNA mutations. This project aims to examine critical mechanisms that affect mitochondrial DNA variation within species. It aims to test the hypothesis that mitochondrial DNA haplotypes have the potential to be under nutritionally induced balancing selection as a consequence of cellular signalling and/or Adenosine triphosphate (ATP) production by mitochondria. Diet can vary both seasonally and geographically and is a key environmental parameter that influences the ability of a species to colonise new habitats. The project plans to characterise the functional links between specific mitochondrial DNA haplotypes, mitochondrial functions and organismal traits. The expected outcome is a more precise grasp of the processes influencing genetic variation within and among species, which would inform current issues in ecology and genetics.Read moreRead less
Information Quality in Auctions of Multiple Objects. This project aims at using both theory and laboratory experiments to analyse the formation of prices and the buyers' behaviour at auctions of multiple objects. The study focusses on the comparison of simultaneous auction procedures (in which the objects are sold at once) to sequential auction procedures (in which the objects are sold one after the other) and attention is drawn on the effects of the quality of the buyers' information about the ....Information Quality in Auctions of Multiple Objects. This project aims at using both theory and laboratory experiments to analyse the formation of prices and the buyers' behaviour at auctions of multiple objects. The study focusses on the comparison of simultaneous auction procedures (in which the objects are sold at once) to sequential auction procedures (in which the objects are sold one after the other) and attention is drawn on the effects of the quality of the buyers' information about the assets to be sold on their bidding behaviour and on the seller's revenues. The conduct of laboratory experiments will provide a useful assessment of the theoretical predictions and valuable insights into the effects of buyers' information quality on their bidding behaviour at such markets.Read moreRead less
Why do only some exotics become invasive? Combining ecological and genomic approaches to address alternative hypotheses in a recent Australian weed. This project will specifically test alternative hypotheses about how weeds become invasive. As invasive weeds affect both agricultural and native ecosystems equally, research on understanding the mechanisms of weed invasion is critical. Outcomes will benefit Australia by allowing better prioritisation of management against exotic plants already i ....Why do only some exotics become invasive? Combining ecological and genomic approaches to address alternative hypotheses in a recent Australian weed. This project will specifically test alternative hypotheses about how weeds become invasive. As invasive weeds affect both agricultural and native ecosystems equally, research on understanding the mechanisms of weed invasion is critical. Outcomes will benefit Australia by allowing better prioritisation of management against exotic plants already in the country by providing predictive tools to estimate likelihood of spread. For formal Pest Risk Analysis by regulators (eg Biosecurity Australia), our project will provide genomic tools by which the potential weediness of a regulated plant can be assessed through genetic screening, and forms part of an international effort to identify 'weedy genes'. Read moreRead less
The biology and epidemiology of the grapevine canker fungi, Botryosphaeria sp. Decline and dieback of grapevines is becoming an increasing problem for the viticulture industry in NSW. Recently, species of the fungus Botryosphaeria, were isolated from grapevines exhibiting these symptoms. In order to understand the biology and epidemiology of the causal organisms, we aim to; (i) determine species of Botryosphaeria present in NSW vineyards; (ii) determine which species are pathogenic on grapevines ....The biology and epidemiology of the grapevine canker fungi, Botryosphaeria sp. Decline and dieback of grapevines is becoming an increasing problem for the viticulture industry in NSW. Recently, species of the fungus Botryosphaeria, were isolated from grapevines exhibiting these symptoms. In order to understand the biology and epidemiology of the causal organisms, we aim to; (i) determine species of Botryosphaeria present in NSW vineyards; (ii) determine which species are pathogenic on grapevines; (iii) characterise the genetic diversity of strains and; (iv) screen fungicides for the control of these fungi. Information on the species, their biology and pathogenicity on grapevines, will enable the development of appropriate management strategies for its control and may lead to the development of molecular tools to identify species of Botryosphaeria.Read moreRead less
Population structure in the giant Australian cuttlefish - implications for management of a unique eco-tourism and fishery resource in regional Australia. A management strategy for the giant Australian cuttlefish in regional South Australia is required urgently because of potential conflict between ecotourism and fishery sectors. At present, development of a management strategy is stymied by lack of information on stock structure and movements. Analyses of variation in gene frequencies, morphom ....Population structure in the giant Australian cuttlefish - implications for management of a unique eco-tourism and fishery resource in regional Australia. A management strategy for the giant Australian cuttlefish in regional South Australia is required urgently because of potential conflict between ecotourism and fishery sectors. At present, development of a management strategy is stymied by lack of information on stock structure and movements. Analyses of variation in gene frequencies, morphometric and chemical trace element profiles in calcified structures among locations and years will enable the geographic extent of populations or stocks to be determined, including whether natal homing occurs. Such information is critical to sustainable management of the species and design of a marine protected area in the upper Spencer Gulf.Read moreRead less
Innovation In The Synthesis And Translation Of Research Evidence To Inform The Prevention, Management And Treatment Of Chronic Disease In Indigenous Populations
Funder
National Health and Medical Research Council
Funding Amount
$2,642,121.00
Summary
Chronic disease remains the principal cause of health inequality for Indigenous Australians. Primary care is critical to mounting a health system response. The Aboriginal community controlled sector is at the coal face of chronic disease management, yet requires the synthesis, utilisation, development, evaluation and translation of evidence to practice. CREATE was established for this purpose
Innovative Health Programs To Reduce Inequality In Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$876,005.00
Summary
As part of his Senior NHMRC Fellowship, Prof Simon Stewart, a world-renowned health services researcher, will lead an internationally linked team of researchers from a broad range of health disciplines to undertake a program of research designed to improve the lives of those most vulnerable to heart disease and poor health outcomes. His program of research will focus on Indigenous Australians, patients with complex forms of heart disease and urban African communities in economic transition.
An In Depth Analysis Of Clinical And Virological Outcomes Of 2 Strategies For The Antiretroviral Salvage Of First-line Regimen Virological Failure For HIV-1 Infection Tested In An Australian-led Randomised, International, Multi-centre Clinical Trial
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
The recently completed Australian-led SECOND-LINE trial is the first high quality study to provide reliable evidence for policy recommendations for the composition of anti-HIV drug cocktails after standard initial treatment has failed. This award will support the researcher in further refining our understanding of how to manage second-line therapy including proposals to test the use of low-cost technologies for application in resource-limited settings where the majority of people with HIV live.