The Role And Inheritance Of Constitutional Epimutations In Early-onset Colorectal Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$347,551.00
Summary
Traditionally familial cancers are thought to be caused by spelling mistakes within the genetic code of cancer prevention genes. Our group has found that chemical attachments to one gene (MLH1) stops it working, even where there is no spelling mistake, and that those chemical changes can be inherited in families with bowel cancer. We will determine how frequently this type of defect occurs in bowel cancer patients, how and why it arises, and if other cancer genes are similarly affected.
Thai Health-Risk Transition: A National Cohort Study - Phase II
Funder
National Health and Medical Research Council
Funding Amount
$1,662,829.00
Summary
We are conducting a pioneering collaborative longitudinal study of population health in Thailand, following over time more than 80,000 adults living throughout the country. We repeatedly measure a wide array of health risks and outcomes. We capture information on the health-risk transition underway in Thailand as the population experiences the new burden of disease associated with economic development and modernisation. We team up with policy makers for national responses to lower the burden.