Solving the puzzle of complex disease - genes and their interactions with the environment. Many human diseases are caused by the interplay of genetic predisposition (nature) and the environment (nurture); but their causes remain a mystery, since much past research has focused on these aspects in isolation. This project will aim to better understand these complex diseases using a multi-factorial approach that brings both nature and nurture together.
Linking Lifestyle And Molecular Biology To Inform Precision Public Health For Major Cancers
Funder
National Health and Medical Research Council
Funding Amount
$8,487,111.00
Summary
The Program of research seeks to increase our understanding of cancer risk. We will use our large collections of population and family-based datasets to conduct innovative analyses, improving our understanding of the roles that genetic, epigenetic and lifestyle factors play in our risk of breast, colorectal and prostate cancer. This information should allow us to better predict a person’s cancer risk, enabling public health interventions, such as screening, to be delivered more effectively and e ....The Program of research seeks to increase our understanding of cancer risk. We will use our large collections of population and family-based datasets to conduct innovative analyses, improving our understanding of the roles that genetic, epigenetic and lifestyle factors play in our risk of breast, colorectal and prostate cancer. This information should allow us to better predict a person’s cancer risk, enabling public health interventions, such as screening, to be delivered more effectively and economically to those most at risk.Read moreRead less
What will it take to decrease socio-economic inequalities in obesity? There is little understanding of how the increasing prevalence of obesity, and its prevention and management, may contribute to socio-economic inequalities in health. This project aims to identify policies that are most likely to both decrease the prevalence of obesity and decrease associated inequalities in health.
A Population-based Family Study Of Filaggrin Mutations And Allergic Disease Risk In Australia
Funder
National Health and Medical Research Council
Funding Amount
$308,584.00
Summary
It is biologically plausible that the association of known environmental risk factors for asthma may be different for genetically susceptible individuals. Few studies have examined the interaction between genetic and environmental factors. that have not considered genetic susceptibility are estimating an average risk of asthma across all genotypes in the population which may not be relevant for a particular sub-group.
Markers Of Androgen Action, Genetic Variation And Prostate Cancer Risk
Funder
National Health and Medical Research Council
Funding Amount
$798,907.00
Summary
This proposal aim to follow up evidence from a number of studies that genetic and non-genetic markers of hormonal action in different periods of a man's life are associated with prostate cancer risk using a collection of three large, independent epidemiologic studies on prostate cancer named the Prostate Cancer Program. A principal objective is to collect exposure data on acne and digit ratio, and genotype cases and controls across the studies of the Prostate Cancer Program for common genetic va ....This proposal aim to follow up evidence from a number of studies that genetic and non-genetic markers of hormonal action in different periods of a man's life are associated with prostate cancer risk using a collection of three large, independent epidemiologic studies on prostate cancer named the Prostate Cancer Program. A principal objective is to collect exposure data on acne and digit ratio, and genotype cases and controls across the studies of the Prostate Cancer Program for common genetic variants in 4 candidate genes in the hormonal pathway. The established risk factors for prostate cancer are only age, race and family history. We anticipate that this project will cast light on the role of hormones in prostate cancer and that we will identify new markers of risk of prostate cancer and markers of disease aggressiveness. These outcomes will help us identifying men who are at risk for prostate cancer to target screening and surveillance, and plan prevention strategies. Furthermore, they will also form the basis for research on treatment targets.Read moreRead less
From science to policy: quantifying and managing the risk of mosquito borne disease in the context of climate change. It is important to assess and manage the health risks of climate change. This research will create fundamental knowledge and practical skills on the interdisciplinary assessment and management of health risks of climate change, and explore policy ramifications of research outcomes in this study.
Understanding individual, workplace and system level influences on return to work in a changing Australian labour market. This project will identify where challenges arise in return to work after a work-related injury or illness for older workers and people with mental stress claims. The results of this project will help form the basis of policy and program changes to address these issues and enable these groups of workers to have better health and economic outcomes.
Effects of feedback and incentive-based insurance on driving behaviours. This project aims to examine the extent to which direct-feedback and incentive-based insurance modify a drivers’ behaviour. The project plans to apply in-vehicle telematics and to link information obtained from the technology directly to personalised safety messaging. The project then plans to assess the impact of this by calculating individual personal injury and the potential reduction to property damage insurance premium ....Effects of feedback and incentive-based insurance on driving behaviours. This project aims to examine the extent to which direct-feedback and incentive-based insurance modify a drivers’ behaviour. The project plans to apply in-vehicle telematics and to link information obtained from the technology directly to personalised safety messaging. The project then plans to assess the impact of this by calculating individual personal injury and the potential reduction to property damage insurance premiums. The study has the potential to profoundly influence not only the insurance industry by reducing individual risk and insurance scheme liability, but also deliver reductions in road trauma among the target population namely, young drivers.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101580
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The impact of the ageing workforce on work injury and compensation systems in Australia. This project seeks to better understand important questions related to work injury and its consequences within the context of the ageing Australian labour market. These include understanding how occupational and age-related factors impact on the risk of work injury and if the relationship between age and recovery and safe return to work after injury.