Mechanisms For The Development Of Leukaemia Via Antibody Hypermutation
Funder
National Health and Medical Research Council
Funding Amount
$82,421.00
Summary
During responses to infection, the antibody genes in responding B cells mutate at a high rate, resulting in B cells producing better antibodies. Although essential for long-lived immunity, antibody mutation involves the introduction of DNA breaks which can occasionally cause leukemia or lymphoma. We understand only poorly how DNA repair systems normally make sure that antibody mutation is benign and does not cause cancer.
The Role Of Membrane Condensation In T Lymphocyte Activation And Signal Transduction
Funder
National Health and Medical Research Council
Funding Amount
$82,421.00
Summary
T cell lymphocytes are essential cells in our immune system. They respond to signals from foreign bodies to mount an immune response. Many diseases arise from errors in their activation processes. The key steps in the translation of the initial arrival of a foreign-body to a T cell into an immune response will be examined in these studies, where we will look at the cooperation of components of the cell membrane during T cell activation. This will help us to understand and treat immune disorders.