Comparative Effectiveness Of Breast Tomosynthesis And Mammography In Real-world Population Screening: Evidence To Underpin And Improve Breast Cancer Screening
Funder
National Health and Medical Research Council
Funding Amount
$1,851,430.00
Summary
This research addresses key evidence gaps in breast cancer screening by investigating tomosynthesis (3D mammography) versus standard 2D mammography screening to establish the effectiveness of tomosynthesis in Australia and internationally, including impact on cancers not detected at screening that progress clinically. Large-scale studies will be done in real world screening services including a prospective comparative study planned collaboratively with BreastScreen to guide screening policy.
Early Detection And Treatment Of Rheumatic Heart Disease In High Risk Communities Using Community-led Approaches For Active Case Finding, Education And Engagement In Care
Funder
National Health and Medical Research Council
Funding Amount
$358,752.00
Summary
Rheumatic heart disease (RHD) affects many Aboriginal and Torres Strait Islander people. Early detection using an ultrasound of the heart (called an “echo”) can help children access treatment. Echo screening in remote communities needs active community participation and leadership in order to succeed. I will study new approaches to community-led echo screening to see if they are accurate enough, evaluate the impact of community involvement and describe outcomes for those diagnosed with RHD.
Realising The World Health Organisation Targets For Elimination Of Cervical Cancer As A Public Health Problem: Effective Implementation And Scale-up Of HPV Vaccination And Cervical Screening In Australia, Regionally, And Globally
Funder
National Health and Medical Research Council
Funding Amount
$2,125,000.00
Summary
This fellowship focuses on improving cancer screening, particularly the implementation of HPV vaccination and cervical screening. CI Canfell will pursue an Australian, regional and global health agenda towards the elimination of cervical cancer. Her work is supporting the successful implementation of the new cervical screening program in Australia, provides crucial support to other countries in the region, and is directly informing the WHO global elimination strategy.
A Risk Stratification Tool For The Prevention Of Avoidable Perinatal Mortality And Morbidity
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Stillbirth is more common in Australia than in some high-income countries. Babies born early may experience lung or other problems. Many current stillbirths and preterm birth can be prevented. Using a cohort of >4.5 million births from WA, NSW, SA and NT (N >4.5 million), this project will develop a strategy to predict the risk of stillbirth, preterm birth, and low birth weight. Better identification of risk in pregnancy will improve antenatal care to reduce stillbirth and neonatal morbidi ....Stillbirth is more common in Australia than in some high-income countries. Babies born early may experience lung or other problems. Many current stillbirths and preterm birth can be prevented. Using a cohort of >4.5 million births from WA, NSW, SA and NT (N >4.5 million), this project will develop a strategy to predict the risk of stillbirth, preterm birth, and low birth weight. Better identification of risk in pregnancy will improve antenatal care to reduce stillbirth and neonatal morbidity.Read moreRead less
Healthy Lungs For Life: A Life Course Approach To Reduce COPD
Funder
National Health and Medical Research Council
Funding Amount
$2,491,398.00
Summary
Chronic Obstructive Lung Disease (COPD) causes breathing distress, disability and premature death. I have shown that COPD mostly has its origins in childhood. This means we can now identify early life risk factors to prevent COPD or help us catch it early, to improve health. My 5-year vision is to reduce the dire burden of COPD by creating evidence to change guidelines and policy and facilitating the transfer of that knowledge to practice.
Genomics For Combating Antimicrobial Resistant Bacterial Pathogens
Funder
National Health and Medical Research Council
Funding Amount
$2,027,364.00
Summary
Applying genomics to bacterial pathogens is revolutionising the way we understand infectious diseases and antimicrobial resistance (AMR). There is a major opportunity to now bring the technology into routine clinical and public health practice. This research program will investigate and deliver the technology of pathogen genomics directly into public health disease surveillance, outbreak detection and the diagnosis and response to infectious diseases and AMR in hospitalised patients.
Advancing The Radical Cure Of Plasmodium Vivax Malaria Through Optimal Antimalarial Regimens
Funder
National Health and Medical Research Council
Funding Amount
$566,164.00
Summary
Forty percent of the global population are at risk of vivax malaria and its associated morbidity. Complete cure of vivax malaria can result in severe anaemia caused by adverse effects of primaquine in vulnerable individuals. My research will provide important evidence for national malaria programs and clinicians, identifying the optimal dosing regimen across different ages and locations, that balances the risks and benefits of primaquine treatment.
Improving Epidemiological Risk Assessment Of Influenza Epidemics
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Severe flu epidemics have killed young mothers, teenagers, young children and many older people in recent years. Systems for monitoring the flu in Australia and other countries are limited in their ability to provide sound risk assessment during an evolving epidemic. The research I lead will show how unused and under-used data sources can be harnessed to provide a strong influenza risk and healthcare impact assessment capability.
Innovation For Health Service Provision And Clinical Management Of Cardiovascular Disease Prevention
Funder
National Health and Medical Research Council
Funding Amount
$1,338,220.00
Summary
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality globally and had a steep rise in burden in low- and middle income countries. A greater focus on a preventative model of care is needed. Frugal innovation is the concept of creating small, low-cost solutions to big problems. My goal is to discover and robustly evaluate in real-world setting low-cost interventions that can be scaled and implemented to reduce the burden of CVD globally.
Alcohol Treatment For Aboriginal Men In And Out Of Prison
Funder
National Health and Medical Research Council
Funding Amount
$607,264.00
Summary
Over half the Aboriginal or Torres Strait Islander people entering prison in NSW have unhealthy alcohol use (drinking over recommended limits, including alcohol dependence). Better access to evidence-based treatment is needed to improve health and reduce return to prison. My proposed research focuses on how clinical and behavioural treatments for alcohol use disorders can be improved on entry to prison, in prison and on release.