A Genetic Study Of Schizophrenia In The Brahmin Of Tamil Nadu
Funder
National Health and Medical Research Council
Funding Amount
$267,226.00
Summary
The cause of schizophrenia is unknown, but there is good evidence that genes play a role. Geneticists do not fully understand how it is inherited, but it is very complex, and several interacting genes as well as environmental factors are probably involved. Societies such as Australia are genetically diverse because people from many different ethnic groups have intermarried. To detect susceptibility genes in this type of population, we must study very large patient samples. Alternatively, we can ....The cause of schizophrenia is unknown, but there is good evidence that genes play a role. Geneticists do not fully understand how it is inherited, but it is very complex, and several interacting genes as well as environmental factors are probably involved. Societies such as Australia are genetically diverse because people from many different ethnic groups have intermarried. To detect susceptibility genes in this type of population, we must study very large patient samples. Alternatively, we can study genetically homogenous patient samples, found in isolated gene-pool populations. One such population is the Brahmin people in Tamil Nadu, a south-eastern state of India. The Brahmin are descended from the Aryan peoples who migrated into southern India 2000 years ago. In the Hindu caste system, Brahmin are the highly educated priest class, and enjoy a privileged position in society. Traditionally, marriages among the Brahmin of Tamil Nadu have been prearranged, with a preference for first-cousin marriages. As well as this cultural and historical evidence, genetic marker studies confirm that this population is a suitable genetic isolate. In this project, genetic material (DNA) will be collected from Brahmin schizophrenic patients and their families. Diagnostic data, detailed family data, and blood samples will be gathered from 90-100 extended families, each containing two or more ill individuals. Analysis of their genetic code will enable a search for possible schizophrenia susceptibility genes and a systematic search for a mutation. If found, this will greatly improve our understanding of schizophrenia, and stimulate the search for similar genes in other samples world-wide, including Australia where schizophrenia costs $3 billion annually in terms of treatment and lost jobs. If schizophrenia genes can be found, it may be possible to find better treatments that correct the basic causes of the illness and identify factors that protect against the illness.Read moreRead less
Use Of Expression Profiling To Identify Genes Influencing Cardiovascular Risk In The Norfolk Island Population Isolate
Funder
National Health and Medical Research Council
Funding Amount
$697,409.00
Summary
This study will use a unique population isolate from Norfolk Island. We aim to identify genes that play a role in cardiovascular disease risk. Norfolk has a population of ~1200 permanent residents, most of whom are direct descendents of 18th century English Bounty mutineers and Polynesian women. We will undertake gene expression mapping to identify genomic loci that influence cardiovascular disease using samples from this population isolate.
Post-market Surveillance Of Medicine-related Adverse Events
Funder
National Health and Medical Research Council
Funding Amount
$99,248.00
Summary
Observational studies using administrative data are an important complement to spontaneous reporting systems for detecting medicine-related adverse events after they go to market, as they reflect real-world use of medicines; yet, they require rigorous methodological approaches to avoid bias. This project will review the existing methodologies for detecting adverse events in administrative data and apply them to Australian data.
Biobank Networks, Medical Research And The Challenge Of Globalisation
Funder
National Health and Medical Research Council
Funding Amount
$790,698.00
Summary
Medical research increasingly relies on large-scale biobanks that store tissue samples from healthy donors or patients. Over the past decade, international networks of biobanks have been established. These are scientifically valuable but raise numerous legal and ethical challenges. In this project we will generate evidence to inform the development of ethically rigorous strategies to ensure that Australian donors and biobanks contribute to, and benefit from, international biobank networks.
Stock Identification And Discrimination Of Mulloway In Australian Waters
Funder
Fisheries Research and Development Corporation
Summary
Objectives: 1. Investigate population structure of mulloway, Argyrosomus hololepidotus, to determine whether mulloway in Australian waters belong to one large inter-breeding population throughout their range or whether 2 or more separate stocks exist.
Shark Futures: A Report Card For Australia's Sharks And Rays
Funder
Fisheries Research and Development Corporation
Funding Amount
$199,997.20
Summary
With growing concerns for the status of shark and ray populations world-wide, and increasing pressure to ensure Australia’s 320 species are effectively managed and conserved, there is a need for decision makers in government to have access to comprehensive and accurate information. One of the greatest challenges for the sharks and rays is that more than any other taxa they exist across the spectrum of interests from sustainable fisheries resources to threatened species requiring conservation. Fu ....With growing concerns for the status of shark and ray populations world-wide, and increasing pressure to ensure Australia’s 320 species are effectively managed and conserved, there is a need for decision makers in government to have access to comprehensive and accurate information. One of the greatest challenges for the sharks and rays is that more than any other taxa they exist across the spectrum of interests from sustainable fisheries resources to threatened species requiring conservation. Further complicating the assessment and management of these species is the fact that many species ranges extend beyond Australia’s territorial waters, where management is implemented differently and populations may be in very different states. Australia’s abilities both in management of its sharks and rays, and the science that underpins it, are recognised as world-leading. Despite this there remain many challenges that face our sharks and rays, but they may not always be those that are faced by other nations in our region. Currently the available information is fragmentary and difficult to access, and most assessment is focused on only a few species targeted by fisheries. The growing information needs of initiatives such as Shark-Plan 2, CITES, CMS, ESD, WTO and EPBC listing struggle to be met because of the lack of a synthesis of information across this group. Locally relevant information on the status of sharks and rays, and the synthesis of knowledge about them, will thus be critical to addressing the challenges that face this group in Australian waters. Objectives: 1. To synthesise available information on sharks and rays in Australian waters 2. To produce a report card on the status of Australia’s sharks and rays Read moreRead less
Population dynamics and genetic variation of plants with contrasting fire responses. We combine the traditional concerns of population viability analyses with the modern techniques of DNA fingerprinting for precise genotyping of individual plants and their seeds. We expect major breakthroughs in our understanding of how fire-killed species have survived thousands of years of frequent burning by Aborigines (by identifying seeds dispersed long distances from burnt parents); how paternity of offspr ....Population dynamics and genetic variation of plants with contrasting fire responses. We combine the traditional concerns of population viability analyses with the modern techniques of DNA fingerprinting for precise genotyping of individual plants and their seeds. We expect major breakthroughs in our understanding of how fire-killed species have survived thousands of years of frequent burning by Aborigines (by identifying seeds dispersed long distances from burnt parents); how paternity of offspring changes over the lifespan of plants which retain their seeds for many years; at what age within-plant genetic variation is at a maximum as a guide to optimal fire management; and the extent that deleterious somatic mutations explain low seed set among long-lived species.Read moreRead less
Sociocultural Determinants Of Childrens Oral Health From Refugee And Migrant Communities
Funder
National Health and Medical Research Council
Funding Amount
$57,342.00
Summary
Refugee and migrant children experience significantly poorer oral health than the non-migrant population. Factors that impact on poor oral health include perceptions of tap water safety, dietary changes, access to prevention and treatment health services, and language barriers. This study will explore reasons for these factors and potential solutions. Communities involved are those which have arrived the most recently and those with large numbers of young children.