Goodness-of-fit Testing And Extensions Of Relative Risk Models
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
Information about the health consequences of exposure to causal factors is obtained from mathematical models of observed data. Relative risk models are recommended for observations over time on a cohort of subjects, but it is not known how best to assess the adequacy of such models or whether they can be applied to ordered outcomes or multiple measurements on the same individuals. These research aims to address those issues, and thereby to increase the practical usefulness of these models.
Integrating Population Genetics, In Silico And Functional Data To Enable Precision Medicine In The Epilepsies
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Epilepsy has proven to be a very genetically tractable neurological disorder. However, while we now routinely identify causal mutations in out patient populations, the process of understanding which are contributing versus which are benign background variation becomes critical as we move towards a period where precision medicine is becoming a reality for some patients. This work will focus on bringing together multiple levels of data to explore integrated models of predicting epilepsy variants.
VACCINE SAFETY RESEARCH In Understudied And At Risk Groups: Critical Knowledge To Inform Practice And Policy.
Funder
National Health and Medical Research Council
Funding Amount
$290,041.00
Summary
Vaccines are typically given to healthy individuals and therefore safety issues loom high on the list of public concerns. Vaccine hesitancy due to safety concerns is an issue of increasing global interest and threatens to lower vaccine uptake. My research aims to understand why some people experience adverse reactions to vaccines, do genetic markers exist?, what are the long term outcomes of a vaccine reaction and how best to communicate vaccine risk/safety to the Australian community.
Understanding And Preventing Population-level Harm From Alcohol
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
This project will support Dr Livingston's world-leading work to better understand the reasons that alcohol consumption and related-harm changes at the population level. It will also support projects that will directly assess the impact of changes to alcohol policies in Australia and the development of policy simulation models, to provide critical evidence and ensure well-informed policy decisions can be made to reduce alcohol-related harm.
International Strategies To Reduce Population Salt Intake
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Effective, sustainable and scalable strategies to reduce salt are needed so countries can achieve the global target to reduce salt by 30% by 2025. This research program will support the optimal development of such strategies through trials and intervention research projects, supplemented through a series of systematic reviews and feasibility and cost-effectiveness assessments. The main outcome will be new evidence on the effectiveness of different interventions to support translation globally.
Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15), CCAAT/enhancer Binding Protein Delta (CEBPD) And Neuroinflammtion
Funder
National Health and Medical Research Council
Funding Amount
$459,270.00
Summary
I will develop new therapies for multiple sclerosis and spinal cord injury. I will also evaluate diagnostic and therapeutic uses for macrophage inhibitory cytokine-1 (MIC-1/GDF15) that was discovered in Australia. I will confirm its use in screening for bowel cancer. Also, I will look at using it in the indigenous and wider Australian community to improve health and close the gap in life expectancy. Finally, I will conduct trials of MIC-1/GDF15 therapy of obesity and inflammation.
Development Of A Low-cost, Very Low-radiation Community-based Screening Method For Primary Prevention Of Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
Virtually everyone's life has been affected by cardiovascular disease (CVD) in some way. There are no routine community-based tests to identify asymptomatic CVD due to current tests being invasive, expensive, time-consuming or high radiation exposure. A low cost, very low radiation test from existing machines used for osteoporosis screening can assess a measure of asymptomatic CVD. This fellowship seeks to develop this test for community-based screening strategies.
Preventing Non-communicable Disease And Promoting Health: Research To Inform Ethical Public Health Action
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
I am a social scientist with public health training. In public health it is routine to ask: How many people are affected by that disease? – or – What interventions work? We also need to begin asking: What is the right thing to do, and how can we tell? I will study the practice of prevention and health promotion, and how lay people manage their health. I will use the resulting evidence, with stakeholders, to develop new approaches to ethical problems, and ensure that interventions can be ethicall ....I am a social scientist with public health training. In public health it is routine to ask: How many people are affected by that disease? – or – What interventions work? We also need to begin asking: What is the right thing to do, and how can we tell? I will study the practice of prevention and health promotion, and how lay people manage their health. I will use the resulting evidence, with stakeholders, to develop new approaches to ethical problems, and ensure that interventions can be ethically justified.Read moreRead less