The life-course implications of declining adolescent drinking. The project aims to identify ways to ensure that recent declines in adolescent drinking are maintained and reinforced as these cohorts age into young adulthood. It expects to generate new knowledge on the trajectories of youth drinking into young adulthood. Expected outcomes include new cross-national understandings of the predictors of heavy drinking in adulthood and an updated evidence base for the development of harm prevention po ....The life-course implications of declining adolescent drinking. The project aims to identify ways to ensure that recent declines in adolescent drinking are maintained and reinforced as these cohorts age into young adulthood. It expects to generate new knowledge on the trajectories of youth drinking into young adulthood. Expected outcomes include new cross-national understandings of the predictors of heavy drinking in adulthood and an updated evidence base for the development of harm prevention policies and interventions by governments and NGOs. This should provide significant benefits to Australia via reductions in the negative health and social impacts of heavy drinking for these cohorts across their lives. Read moreRead less
Improving health and criminal justice outcomes among Australia's offender population using a multi-disciplinary, all of government approach. Offender populations comprise some of the most marginalised and socially excluded individuals in society. With this comes poor health, engagement in risk behaviours and reduced social outcomes. Violence, mental health, infectious diseases, and substance misuse are all characteristics of offender populations and have a huge impact on the wider community. The ....Improving health and criminal justice outcomes among Australia's offender population using a multi-disciplinary, all of government approach. Offender populations comprise some of the most marginalised and socially excluded individuals in society. With this comes poor health, engagement in risk behaviours and reduced social outcomes. Violence, mental health, infectious diseases, and substance misuse are all characteristics of offender populations and have a huge impact on the wider community. The research programme linked to this application will collect new information aimed at reducing this impact and also develop a much needed intervention to reduce violent reoffending. Indigenous people are over-represented in the Australian prison system and will benefit from the work programme associated with this application.Read moreRead less
Excessive sitting and population health: strengthening the science and the relevance to policy and practice. The majority of Australian adults spend most of their waking hours sitting; this increases the likelihood of developing diseases of inactivity, including diabetes, heart disease and some cancers. New research will investigate what factors encourage excessive sitting and what the health benefits are for people who deliberately do less sitting.
Linking evolutionary and molecular biology to safeguard Australian honeybees. Honeybee populations are declining globally but their pollination services are of central importance for food production. This project will study honeybee proteins that influence both fertility and immunity and their effects in vivo. This knowledge is of interest for the bee breeding industry to avoid or combat bee declines in managed Australian bees.
From causative genes to establishing therapies for patients with neuromuscular diseases. A major focus of this project will be pursuing multiple therapeutic approaches for a class of skeletal muscle diseases, which are most often severe and lethal within the first year of life. It will also hunt down the defective genes in human patients with other neuromuscular diseases and explore how these cause disease.
What drives novel community formation? Mechanisms of resilience against invasion and native species persistence under land use change. Environmental change is driving the creation of novel communities, stable mixes of native and exotic species. These communities are inevitable outcomes of human-induced environmental changes, yet why and how they form is still poorly understood. As these communities maintain high levels of native biodiversity, they are of great conservation value. Using Western A ....What drives novel community formation? Mechanisms of resilience against invasion and native species persistence under land use change. Environmental change is driving the creation of novel communities, stable mixes of native and exotic species. These communities are inevitable outcomes of human-induced environmental changes, yet why and how they form is still poorly understood. As these communities maintain high levels of native biodiversity, they are of great conservation value. Using Western Australia wildflower communities, This project aims to provide the first experimental tests of which environmental and biotic factors drive novel community formation, native species persistence and resilience to invasion. This will be important for developing realistic conservation plans in many ecosystems globally, and more specifically in Western Australia's biodiversity hotspot.Read moreRead less
Building better Brassicas: Understanding disease resistance mechanisms across the Brassicaceae. Brassica species are important crops producing cooking oil, vegetables and biofuel, grown in diverse environments with a high economic and export value. Blackleg disease, caused by the fungus Leptospheria maculans, is the most important disease of brassica crops world-wide. The newly available brassica genome sequence provides the resources to study the co-evolution of this plant and pathogen. This pr ....Building better Brassicas: Understanding disease resistance mechanisms across the Brassicaceae. Brassica species are important crops producing cooking oil, vegetables and biofuel, grown in diverse environments with a high economic and export value. Blackleg disease, caused by the fungus Leptospheria maculans, is the most important disease of brassica crops world-wide. The newly available brassica genome sequence provides the resources to study the co-evolution of this plant and pathogen. This project will characterise the evolution and conservation of resistance genes in wild and cultivated brassicas, using next-generation sequencing technology, to assess their potential for crop improvement. An understanding of the evolution of genes responsible for resistance will lead to improved plant protection strategies for brassica crops.Read moreRead less
Group dynamics, Allee effects and population regulation in cooperative breeders. Understanding population dynamics is crucial for effective conservation biology. In many cases breeding is limited by high density, but in social species the opposite is true, exposing small groups to high extinction risk. However, analyses of population dynamics in social species is rare, limiting our ability to effectively conserve such species.
Advanced macromolecular engineering: novel approaches to self-directed assembly and vesicle formation. The aim of this project is to develop new approaches in nanotechnology for the preparation of well-defined polymeric particles. The research will result in the development of new methodology which has the potential to impact areas of commercial interest including those in the health-care sector.
Masterminding Reproduction: Kisspeptin and RFamide-Related Peptide. There are a number of concerning trends in reproductive health. Women are reporting difficulty conceiving and maintaining pregnancies; while sperm count and quality are declining in men. More concerning is the increase in reproductive cancers. Gonadotropin-releasing hormone (GnRH) antagonist and agonist have been used for decades to treat reproductive cancers (such as breast cancer and prostate cancer), infertility and precociou ....Masterminding Reproduction: Kisspeptin and RFamide-Related Peptide. There are a number of concerning trends in reproductive health. Women are reporting difficulty conceiving and maintaining pregnancies; while sperm count and quality are declining in men. More concerning is the increase in reproductive cancers. Gonadotropin-releasing hormone (GnRH) antagonist and agonist have been used for decades to treat reproductive cancers (such as breast cancer and prostate cancer), infertility and precocious puberty. Kisspeptin and RF-related peptide may offer more physiological alternatives to GnRH, without detrimental side effects. We will fully explore these two newly defined and major players in reproduction and provide a physiological framework for their progression to clinical use.Read moreRead less