QTL Linkage Analysis For Complex Human Traits In Twin Families
Funder
National Health and Medical Research Council
Funding Amount
$1,000,000.00
Summary
This project will focus on finding genes for common human diseases. Now that the human genome has been sequenced, the race is on to find out what the estimated 38,000 human genes do and which ones are associated with which diseases. Scattered throughout the genome are small variations in DNA sequence, some of which increase the odds of disease while others are protective.
Modelling The Biology And Transmission Of Influenza Virus - Learning From 1918-19 And Other Outbreaks
Funder
National Health and Medical Research Council
Funding Amount
$114,222.00
Summary
In preparing for a future pandemic of influenza, it is important to learn as much as possible from what happened in the past, particularly from the devastating pandemic of 1918-19. This project will collate detailed information about the spread of influenza in past outbreaks and create a publicly accessible data-base. Mathematical methods will be used to analyse historic and contemporary data, so as to provide better understanding of the spread of influenza, and of the likely effects of social a ....In preparing for a future pandemic of influenza, it is important to learn as much as possible from what happened in the past, particularly from the devastating pandemic of 1918-19. This project will collate detailed information about the spread of influenza in past outbreaks and create a publicly accessible data-base. Mathematical methods will be used to analyse historic and contemporary data, so as to provide better understanding of the spread of influenza, and of the likely effects of social and medical measures for its control. An important theme of the project is to consolidate our knowledge about how past exposure to non-pandemic influenza could provide short-lived protection against any new pandemic, and to explore the implications of this for prevention today. Another theme is to explore the severity of influenza during pandemics, and to identify social and medical factors that might reduce the dose of virus transmitted, or otherwise reduce the severity of infection. The insights from the modeling will also help to identify gaps in knowledge and understanding about the basic biology of influenza, stimulate new research to fill those gaps, and thus offer the prospect of more effective vaccines and treatments for the future control of influenza.Read moreRead less
Determining Critical Points In The Potential Palliative Care Pathway In The Last Year Of Life
Funder
National Health and Medical Research Council
Funding Amount
$356,461.00
Summary
People with serious illnesses who are approaching the end of their lives undergo a journey where, along the way, they experience several critical points. Although we know these critical points are crucial to how they might access the best kind of care, we are unsure exactly when these points may occur and how they may vary for different kinds of people. We need to know when is the best time to start withdrawing invasive and purely curative treatments, when are discussions about approaching death ....People with serious illnesses who are approaching the end of their lives undergo a journey where, along the way, they experience several critical points. Although we know these critical points are crucial to how they might access the best kind of care, we are unsure exactly when these points may occur and how they may vary for different kinds of people. We need to know when is the best time to start withdrawing invasive and purely curative treatments, when are discussions about approaching death best introduced and how we can care for people from a diverse range of backgrounds and beliefs within our current health care system. We also need to identify and promote the best possible ways of supporting patients at the end of life and their families as they negotiate the often complex path towards a good death. With this kind of information, health care practitioners, particularly those involved in palliative care, can design better services that put in place pathways where assessment of patient and family needs, referral to the most appropriate services and coordination of all the aspects of care are easy to understand and access for all people. This kind of care can be expensive so we need to use the money allocated to palliative care wisely. This can be achieved with thoughtful research that identifies those most in need, at the time of most need and investigates the best approaches to alleviating pain in suffering in the weeks and months before death. A fair and equitable health care system is not just about keeping people healthy, but also about dealing humanely with the inevitability of deathRead moreRead less
Development And Implementation Of An Educational Program To Guide Palliative Care For People With Motor Neurone Disease
Funder
National Health and Medical Research Council
Funding Amount
$258,525.00
Summary
The project aims to improve the quality of care for people with MND and their family carers through the development, testing and implementation of an educational program for health professionals and other service providers focused on the palliative care needs of this population. The project is taking place in three sites: Western Australia, Victoria and South Australia, in collaboration with the MND associations in the three states. The effectiveness of the flexible model of care provided to peo ....The project aims to improve the quality of care for people with MND and their family carers through the development, testing and implementation of an educational program for health professionals and other service providers focused on the palliative care needs of this population. The project is taking place in three sites: Western Australia, Victoria and South Australia, in collaboration with the MND associations in the three states. The effectiveness of the flexible model of care provided to people with MND and their carers as a result of the implementation of the MND Education Program will be assessed and a national implementation plan will be developed.Read moreRead less
Examining A Core Assumption Of Policy And Services For Older Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$133,387.00
Summary
In aged care service planning, the age 50 years or over is used for the Indigenous Australian population in the same way as the age 70 years is used for the non-Indigenous population. This is based on the lower life expectancy of the Indigenous population which is presumed to result in a need for aged care services at younger ages. The underlying assumption is that Australia's Indigenous population aged over 50 has the same set of age-associated conditions and care needs as the non-Indigenous po ....In aged care service planning, the age 50 years or over is used for the Indigenous Australian population in the same way as the age 70 years is used for the non-Indigenous population. This is based on the lower life expectancy of the Indigenous population which is presumed to result in a need for aged care services at younger ages. The underlying assumption is that Australia's Indigenous population aged over 50 has the same set of age-associated conditions and care needs as the non-Indigenous population aged over 70. The evidence for this assumption is not established. It is well documented that the Indigenous population has worse health outcomes across all age groups relative to non-Indigenous Australians. However, our understanding of the details of the observed pattern is far from complete. This project seeks to compare the health status of the Indigenous population aged 50 years or over to the health status of the non-Indigenous population aged 70 years or over. The project will analyse a number of data sets to inform future directions in policy and service provision. A better understanding of these issues is fundamental to informed planning and allocation of resources, to identification of areas amenable to prevention strategies and to the development of approaches to care that meet the needs of Indigenous people.Read moreRead less
Better Targeting Of Preventive Services Using Epidemiological Modelling
Funder
National Health and Medical Research Council
Funding Amount
$1,951,463.00
Summary
The purpose of this program of research is to improve the effectiveness of chronic disease prevention in Australia. The focus is to develop epidemiological models that can assist policy-makers to make more informed choices of which preventive programs to fund, improve the ability of clinicians to provide accurate preventive advice and to increase the ability of consumers to make decisions about preventive activities (that may relate to themselves or their communities). Australian population tren ....The purpose of this program of research is to improve the effectiveness of chronic disease prevention in Australia. The focus is to develop epidemiological models that can assist policy-makers to make more informed choices of which preventive programs to fund, improve the ability of clinicians to provide accurate preventive advice and to increase the ability of consumers to make decisions about preventive activities (that may relate to themselves or their communities). Australian population trends over coming years will be dominated by increasing numbers of elderly and a continuing increase in average lifespan. A priority for preventive healthcare is to maintain the elderly in a healthy active state, free of chronic disease, for as long as possible. Options to achieve this are increasing but vary in terms of likely effectiveness and cost-effectiveness. Since many of the costs and benefits of preventive programs occur beyond the time-scale of major intervention trials, the prediction of long-term benefits requires the integration of information from multiple sources including trials, epidemiological studies, risk-factor surveys and demography through a process referred to as epidemiological modelling. This project has major relevance to consumers, allied health professionals and Aboriginal and Torres Strait Islander people. One outcome of the project will be to allow consumers to make informed decisions about their preventive health care and will assist allied health professionals providing preventive advice to patients. These include occupational health nurses, health promotion officers, Aboriginal health workers and nurse practitioners.Read moreRead less
Effect Of A Personalised Oral Health Education Programme On Clinical And Molecular Risk Factors For At-risk Populations
Funder
National Health and Medical Research Council
Funding Amount
$149,900.00
Summary
Recently, a number of studies have shown that poor oral health may impact on general health. However, for many Australians on low incomes, the only dental care they receive is of an emergency nature due to the long waiting lists in the public sector. The current study proposes to look at whether an oral health education program delivered by allied oral health professionals will result in a significant improvement in oral health which in turn will lead to better oral and general health outcomes i ....Recently, a number of studies have shown that poor oral health may impact on general health. However, for many Australians on low incomes, the only dental care they receive is of an emergency nature due to the long waiting lists in the public sector. The current study proposes to look at whether an oral health education program delivered by allied oral health professionals will result in a significant improvement in oral health which in turn will lead to better oral and general health outcomes in a low socio-economic communityRead moreRead less
A Model Of Current & Potential Palliative Care Constituency: Measuring Met & Unmet Needs
Funder
National Health and Medical Research Council
Funding Amount
$145,210.00
Summary
Although many health care providers believe palliative care should be offered to all Australians who need it, there is no population-based data to support this claim. This study will provide much needed population-based evidence by measuring the levels of met and unmet needs of people with active, progressive, advanced disease in the last 12 months of their lives. A model of current and potential palliative care constituency will be developed that will lead to improved access to palliative care ....Although many health care providers believe palliative care should be offered to all Australians who need it, there is no population-based data to support this claim. This study will provide much needed population-based evidence by measuring the levels of met and unmet needs of people with active, progressive, advanced disease in the last 12 months of their lives. A model of current and potential palliative care constituency will be developed that will lead to improved access to palliative care for people who do not traditionally access specialist palliative care services.Read moreRead less
Dementia Literacy In Greek, Italian And Chinese Australians
Funder
National Health and Medical Research Council
Funding Amount
$228,473.00
Summary
The dementia knowledge and beliefs of persons from Italian, Greek and Chinese backgrounds will be compared to third generation Australians. Five hundred persons from each group will be randomly selected from around Australia to be surveyed by telephone. Questions will assess whether dementia symptoms are recognised, what these persons think causes dementia, where they would go for help, how likely they are to use aged care services and stigma towards persons with dementia. Focus groups will be c ....The dementia knowledge and beliefs of persons from Italian, Greek and Chinese backgrounds will be compared to third generation Australians. Five hundred persons from each group will be randomly selected from around Australia to be surveyed by telephone. Questions will assess whether dementia symptoms are recognised, what these persons think causes dementia, where they would go for help, how likely they are to use aged care services and stigma towards persons with dementia. Focus groups will be conducted to identify barriers to service use and identify methods to improve dementia knowledge in Italian, Greek and Chinese groups. This information will be used to improve community education and service delivery for persons with dementia from culturally and linguistically diverse backgrounds. The Primary Dementia Collaborative Research Centre at the University of NSW, NSW Multicultural Health Communication Service and Alzheimer’s Australia are partners in this research.Read moreRead less