Engineering the trafficking of nanoparticles within cells. This project aims to engineer responsive nanoparticles capable of trafficking efficiently within cells. The site of release of therapeutic cargo has importance for improving the efficacy of many treatments, for example vaccine delivery. Therefore fundamental understanding of how nanoparticle structure can be engineered to control cellular behaviour is necessary. The project will engineer new polymeric nanomaterials and investigate the im ....Engineering the trafficking of nanoparticles within cells. This project aims to engineer responsive nanoparticles capable of trafficking efficiently within cells. The site of release of therapeutic cargo has importance for improving the efficacy of many treatments, for example vaccine delivery. Therefore fundamental understanding of how nanoparticle structure can be engineered to control cellular behaviour is necessary. The project will engineer new polymeric nanomaterials and investigate the impact of their structure on biological properties. The benefits of this project will include new fundamental insights into improving nanoparticle design for vaccine delivery, as well as the expansion of Australia’s knowledge base in the area of biodegradable polymers.Read moreRead less
Bioinspired interfaces for improved carbon fibre composite performance. Carbon fibre composites, where carbon fibres are embedded in a polymer matrix, are gradually replacing traditional materials such as steel. For example, composites make up 50 per cent of Boeing’s 787 Dreamliner, resulting in a 20 per cent improvement in fuel economy. There is significant scope for improving the damage tolerance of these materials. A fundamental lack of understanding around the fibre matrix interface currentl ....Bioinspired interfaces for improved carbon fibre composite performance. Carbon fibre composites, where carbon fibres are embedded in a polymer matrix, are gradually replacing traditional materials such as steel. For example, composites make up 50 per cent of Boeing’s 787 Dreamliner, resulting in a 20 per cent improvement in fuel economy. There is significant scope for improving the damage tolerance of these materials. A fundamental lack of understanding around the fibre matrix interface currently limits the development of new composite systems to overcome the problems with damage tolerance. This project takes inspiration from nature to develop a fundamental understanding of the interfaces within carbon fibre composites and optimise their behaviour via model-guided surface and interface engineering. Read moreRead less
A new generation high crash energy absorbing barrier for improved road safety. The new, high energy absorbing road safety barrier developed in this project will provide better protection for all road users than current barriers by reducing the severity of car crashes. Current road barriers result in an average loss of 1600 lives in Australia annually, including a disproportionate number of young lives. The new barrier will be highly efficient in absorbing collisions from vehicles travelling at s ....A new generation high crash energy absorbing barrier for improved road safety. The new, high energy absorbing road safety barrier developed in this project will provide better protection for all road users than current barriers by reducing the severity of car crashes. Current road barriers result in an average loss of 1600 lives in Australia annually, including a disproportionate number of young lives. The new barrier will be highly efficient in absorbing collisions from vehicles travelling at speeds between 60 to over a 100 kilometres per hour. Installation of the new road safety barrier systems in high accident zones will save lives by reducing the severity of accidents involving road barriers. This will significantly benefit the community by reducing injury, medical, rehabilitation and property damage costs, and improve quality of life for all road users.Read moreRead less
Conducting polymer materials. This project aims to understand the optical, electrical and optoelectronic properties of conductive polymers by studying how ions influence the charge transport through the polymeric structure. The discovery of conductive polymers in the 1970s led to smartphone and laptop touch displays and solar cells. These materials promise even more still – but how they operate at the atomic level is not understood. This project could lead to an ability to harness and control th ....Conducting polymer materials. This project aims to understand the optical, electrical and optoelectronic properties of conductive polymers by studying how ions influence the charge transport through the polymeric structure. The discovery of conductive polymers in the 1970s led to smartphone and laptop touch displays and solar cells. These materials promise even more still – but how they operate at the atomic level is not understood. This project could lead to an ability to harness and control these properties for energy storage and wearable displays. These materials’ biological neutrality could lead to drug delivery and sensing applications in the agriculture and healthcare spaces.Read moreRead less
New stimuli-responsive polymer membranes using graphene as a multifunctional scaffold. Membranes are used in a range of applications to filter liquids and gases and increasingly must be able to be activated by stimuli such as temperature, pH and voltage. We will develop a new type of membrane which is easy to make, is strong and allows the incorporation of a variety of stimuli-responsive polymers within a functional graphene scaffold.
Tailoring the nanoporous structure of polymer membranes for fast water permeation. A novel strategy of using a hydrophobic, charged polymer as an additive is proposed to tailor the wettability and charge density gradients in nanoporous polymer membranes for enhancing water permeation. The experimental results obtained in this project will advance our fundamental understanding of the roles of the pore surface charge and wettability gradients in water transport through nanopores. The proposed rese ....Tailoring the nanoporous structure of polymer membranes for fast water permeation. A novel strategy of using a hydrophobic, charged polymer as an additive is proposed to tailor the wettability and charge density gradients in nanoporous polymer membranes for enhancing water permeation. The experimental results obtained in this project will advance our fundamental understanding of the roles of the pore surface charge and wettability gradients in water transport through nanopores. The proposed research is expected to result in a major breakthrough in designing nanoporous membranes with ultrahigh high flux and superior separation properties for a variety of applications including water treatment and food processing. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101550
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Functional polymer encapsulation to enhance biological performance of implantable materials. This project will develop biomaterial films from essential oils using a low-cost 'green' technology. Applied to commercial biomaterials, these films will minimise infections and inflammations commonly associated with implants. These films will also enable clinical use of metallic resorbable implants for tissue engineering and function restoration.
New bar-encoded polymer microbeads for multiplexed bioanalysis-a quick and high-throughput approach for complex disease diagnosis. Distinguishable new bar-encoded (element-encoded) polymer microbeads associated with a mass spectroscopy-flow cytometer detector provide a novel platform for highly multiplexed biological analysis. Such an approach can simultaneously identify many non-self-agents at low concentrations, which facilitates early-stage complex disease diagnosis.
Feedthrough technologies for polymeric encapsulated active implants. The project will address the scientific challenges of signal transfer between tissue and novel active implantable medical devices, with major implications for cochlear implant manufacture. This will lead to improvements in the quality of life of the hearing-impaired, and will make an important contribution to the development of other sensory implants.
A high speed, high fidelity 3D printer for fabricating microfluidic devices. This project aims to develop a novel 3D printer offering the highest resolution available and fastest printing speed for the single-step manufacturing of complex microfluidic devices. New resins developed to exploit the inert liquid interface layer printing approach will provide unprecedented capability to create micron sized channels interconnected in 3D space and fabricate Lab-on-a-Chip systems that cannot be generate ....A high speed, high fidelity 3D printer for fabricating microfluidic devices. This project aims to develop a novel 3D printer offering the highest resolution available and fastest printing speed for the single-step manufacturing of complex microfluidic devices. New resins developed to exploit the inert liquid interface layer printing approach will provide unprecedented capability to create micron sized channels interconnected in 3D space and fabricate Lab-on-a-Chip systems that cannot be generated by any current fabrication approach. This novel high speed, high fidelity 3D printer and the new resins to be developed are expected to lead to more effective manufacturing approaches for portable chemical devices and to promote complex chemical analysis into the knowledge immediacy culture of today.Read moreRead less