Force-mediated dynamic chemistry in hydrogels. This project aims to develop a new class of biomimetic material, where applied force modulates the chemistry and mechanics by incorporating mechanochemical responsive linkages in hydrogel networks. This work intends to generate new knowledge in the chemistry and mechanical properties of soft materials using an interdisciplinary approach involving synthesis, computational modelling, and mechanical analysis. Expected outcomes include novel hydrogel ma ....Force-mediated dynamic chemistry in hydrogels. This project aims to develop a new class of biomimetic material, where applied force modulates the chemistry and mechanics by incorporating mechanochemical responsive linkages in hydrogel networks. This work intends to generate new knowledge in the chemistry and mechanical properties of soft materials using an interdisciplinary approach involving synthesis, computational modelling, and mechanical analysis. Expected outcomes include novel hydrogel materials that are mechanochemically active, tough, and fatigue resistant, along with design criteria for force-activated molecule immobilisation and release expected to provide significant benefit forbiomedical applications, additive manufacturing, soft robotics and flexible electronics.Read moreRead less
Biofabricated tissue mimics for nanoparticle design and development. Nanoparticles are widely used in commercial applications spanning biotechnology, health and environmental monitoring, and drug delivery. Materials scientists can generate large libraries of nanoparticles, but the toolbox available to test these nanoparticles is limited. We will use biofabrication to comprehensively evaluate the fate of polymer grafted nanocellulose across simulated tissue barriers. Model blood vessels with reci ....Biofabricated tissue mimics for nanoparticle design and development. Nanoparticles are widely used in commercial applications spanning biotechnology, health and environmental monitoring, and drug delivery. Materials scientists can generate large libraries of nanoparticles, but the toolbox available to test these nanoparticles is limited. We will use biofabrication to comprehensively evaluate the fate of polymer grafted nanocellulose across simulated tissue barriers. Model blood vessels with recirculating flow will help understand permeation; tunable matrices will establish ‘matrix structure—nanoparticle diffusion’ criteria. The outcome from this project will be an understanding of how plastic nanoparticles penetrate tissue, to guide nanomaterials design and mitigate risk associated with toxicity. Read moreRead less