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New methods to improve regional isotope therapy of liver tumours in cancer patients. The most common cause of death in cancer patients is secondary tumours in vital organs. Successful treatment of liver tumours with regional isotope therapy now offers improved survival rates. This project will research novel radiolabelled nanoparticles and advanced computer imaging algorithms to improve regional isotope therapy of liver tumours. It will provide better methods of objective assessment and manageme ....New methods to improve regional isotope therapy of liver tumours in cancer patients. The most common cause of death in cancer patients is secondary tumours in vital organs. Successful treatment of liver tumours with regional isotope therapy now offers improved survival rates. This project will research novel radiolabelled nanoparticles and advanced computer imaging algorithms to improve regional isotope therapy of liver tumours. It will provide better methods of objective assessment and management that can reduce risk and improve patient survival.Read moreRead less
Non-invasive diagnosis using micropatches that sample biomarkers from skin. We are developing a technology called the micropatch that is laid onto the surface of the skin. When the patch is pulled away, it retains proteins found in the subsurface skin layers. We believe that by analysing these proteins we will be able to diagnose diseases like cancer earlier and therefore have a better chance of treating them successfully. The process is painless, and doctors already use it to give drugs and vac ....Non-invasive diagnosis using micropatches that sample biomarkers from skin. We are developing a technology called the micropatch that is laid onto the surface of the skin. When the patch is pulled away, it retains proteins found in the subsurface skin layers. We believe that by analysing these proteins we will be able to diagnose diseases like cancer earlier and therefore have a better chance of treating them successfully. The process is painless, and doctors already use it to give drugs and vaccines. In the future we hope that our technology will be simple enough for routine diagnosis, even in the Outback where doctors are hundreds of kilometres awayRead moreRead less
Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics ....Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics for use in real world applications. The project has two aspects. First, relatively small directed cDNA-bead libraries will be compared to known low-density cDNA microarrays to validate the technique for utility in gene expression profiling. Secondly, large libraries containing short oligonucleotide sequences will be used for de novo sequencing of a complete transcriptome. Proof-of-concept in either case will pave the way for many genomic applications and catapult the technology to 'blockbuster' status.Read moreRead less
Measurement and imaging of pathogenic and diagnostic iron oxide nanoparticles using proton magnetic resonance. This project is likely to result in new and improved technologies to aid in the management and diagnosis of a range of diseases including iron metabolism disorders such as thalassaemia and neurodegenerative diseases such as Alzheimer's disease. Other aspects of the research may lead to technologies for the early detection of some cancers. The technologies will enhance Australia's intern ....Measurement and imaging of pathogenic and diagnostic iron oxide nanoparticles using proton magnetic resonance. This project is likely to result in new and improved technologies to aid in the management and diagnosis of a range of diseases including iron metabolism disorders such as thalassaemia and neurodegenerative diseases such as Alzheimer's disease. Other aspects of the research may lead to technologies for the early detection of some cancers. The technologies will enhance Australia's international standing in the field of advanced medical imaging and have the potential to be commercialised within the Australian biotechnology sector. During the project, research students will receive high quality multidisciplinary training ensuring the supply of personnel with high-level technical expertise into the future.Read moreRead less
Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to dete ....Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to detect parasite products in stool. Such testing technology is amenable to configuration in a robust format, suitable for large-scale manufacture. Given the worldwide prevalence of these parasites, the tests will have a market potential of international significance.Read moreRead less
Multimodal biomedical imaging probes: development of advanced polymer nanocomposite devices for oncology. Despite significant research being directed toward cancer treatment, 7.6 million people died world wide in 2007. Early detection and treatment is widely recognised as being effective in significantly reducing mortality rates. Biomedical imaging techniques are routinely used for detection and staging of many cancers. However, greater sensitivity is required so that these techniques can be app ....Multimodal biomedical imaging probes: development of advanced polymer nanocomposite devices for oncology. Despite significant research being directed toward cancer treatment, 7.6 million people died world wide in 2007. Early detection and treatment is widely recognised as being effective in significantly reducing mortality rates. Biomedical imaging techniques are routinely used for detection and staging of many cancers. However, greater sensitivity is required so that these techniques can be applied to very early detection of tumours. To overcome this short-coming the next generation of imaging probes will be developed, which will require fundamental investigations in polymer and nanomaterials science to maximise imaging sensitivity and extend probe functionality. Successful outcomes will lead to significant benefits to healthcare in Australia.Read moreRead less
Understanding the implications of pandemic delays for the end of life. The untold toll of Covid-19 is emerging in ‘avoidable deaths’ linked to late(r) diagnosis or treatment due to pandemic-related delay. How delays are experienced and felt across families and communities requires urgent attention. This project aims to understand the implications of pandemic delay for dying and bereavement, including the sociocultural factors that shape experiences of illness and care amid delay. The significanc ....Understanding the implications of pandemic delays for the end of life. The untold toll of Covid-19 is emerging in ‘avoidable deaths’ linked to late(r) diagnosis or treatment due to pandemic-related delay. How delays are experienced and felt across families and communities requires urgent attention. This project aims to understand the implications of pandemic delay for dying and bereavement, including the sociocultural factors that shape experiences of illness and care amid delay. The significance of this project lies in its innovative sociological approach; expected outcomes include the generation of new knowledge on needs at the end of life that move across contexts and settings. Benefits include provision of findings that will inform social and health policy and practice improvements to enable good deaths.Read moreRead less
Developing a Model of ICU Transition Care; Enhancing Services, Enabling Nurses, Empowering Patients. The transition from the Intensive Care Unit (ICU) to the ward is traumatic for patients and families and difficult for ward nurses. Using focus groups and an intervention study, this research will develop and evaluate a model of ICU transition care and demonstrate the extent to which appropriate transition care improves a variety of outcomes for patients, families and staff. We anticipate that t ....Developing a Model of ICU Transition Care; Enhancing Services, Enabling Nurses, Empowering Patients. The transition from the Intensive Care Unit (ICU) to the ward is traumatic for patients and families and difficult for ward nurses. Using focus groups and an intervention study, this research will develop and evaluate a model of ICU transition care and demonstrate the extent to which appropriate transition care improves a variety of outcomes for patients, families and staff. We anticipate that this model will influence practice and policy decisions and be useful in other setting and with other groups who face life transitions such as the military, corrective care and rehabilitation.Read moreRead less
Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science an ....Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science and technology infrastructure within Australia, taking it into original and exciting directions, contribute to training young Australian scientists and students, as well as enhance Australia's competitive position in the field of nanobiotechnology.Read moreRead less
Bioanalytical Microchips Based on Integrated, Application Tailored Monolithic Modules. Microfluidic devices offer substantial advantages over current technology, in terms of speed, cost of analysis, portability, operator simplicity and safety. Integrating multiple analytical processes within a simple and reliable portable device will lead to application in a range of areas, from pharmacology to therapeutic drug monitoring, proteomic and metabolomic screening for disease diagnosis and drug develo ....Bioanalytical Microchips Based on Integrated, Application Tailored Monolithic Modules. Microfluidic devices offer substantial advantages over current technology, in terms of speed, cost of analysis, portability, operator simplicity and safety. Integrating multiple analytical processes within a simple and reliable portable device will lead to application in a range of areas, from pharmacology to therapeutic drug monitoring, proteomic and metabolomic screening for disease diagnosis and drug development, and also for performing clinical diagnostics in a rural area. This will significantly impact on the quality of life of the Nation as a whole, not only due to expedient diagnosis and treatment which has obvious health benefits, but also in the considerable financial benefits that result from early and efficient treatment. Read moreRead less