Identifying The Microbiological Risk Factors For Acute Lower Respiratory Infection In Indigenous Children To Inform Future Intervention Strategies
Funder
National Health and Medical Research Council
Funding Amount
$495,745.00
Summary
Lung infections such as pneumonia are common in Indigenous children, and can lead to repeated hospitalisation and permanent lung damage. They are also an important cause of preventable death in children. This study will look at the role of bacteria and viruses in lung infections, and will inform interventions to reduce the burden and consequences of lung infections in Indigenous children.
A Prospective Study Of The Aetiology, Associations, Clinical Features And Outcomes Of Community-acquired Pneumonia In Children And Adults In Tropical Australia
Funder
National Health and Medical Research Council
Funding Amount
$106,937.00
Summary
Pneumonia is common in Australia and often requires hospital admission. The germs that cause pneumonia in tropical Australia are less well known than southern Australia and likely to be different. This study will identify which germs cause pneumonia in people in tropical Australia and will identify which people become more unwell. I aim to identify the best antibiotics to use, the differences between children and adults, Indigenous and non-Indigenous people and people living in different areas.
A Multi-centre Double-blind RCT On Community-acquired Pneumonia In Indigenous Children And A Developing Country: Improving Clinical Outcomes And Identifying Systemic Biomarkers
Funder
National Health and Medical Research Council
Funding Amount
$2,167,560.00
Summary
Young children of Indigenous communities and developing countries are often hospitalised for pneumonia and have high risk of subsequent chronic disease. Our international study will determine if a longer duration of antibiotics (compared to shorter duration) improves the short and long term clinical outcomes of children hospitalised for pneumonia. We will look for unique markers that may predict those who will develop chronic lung disease. Our study will influence future guidelines on pneumonia.
Molecular Public Health In Australian Indigenous Communities And Developing Countries In Our Region To Improve Ear And Respiratory Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
Prevention of pneumonia and ear disease is of global importance. This study aims to improve outcomes for children living in remote Indigenous communities and Developing countries in our Region. Vaccines and antibiotics are powerful health tools, but often fail in high-risk populations for these diseases. Technological advances allow us to better examine the causes of pneumonia and ear disease and measure effects of vaccines and antibiotics. This will allow us to design improved interventions.
Single Versus Combination Pneumococcal Conjugate Vaccines (13PCV And PHiD-CV) For High-risk Aboriginal Children (COMBO)
Funder
National Health and Medical Research Council
Funding Amount
$3,017,464.00
Summary
Two new pneumococcal vaccines, each offering protection from different pneumococcal strains and pathogens will soon be available. At this time, health experts do not know which vaccine will be best for Indigenous children. The hypothesis of this project is that both vaccines, given as a 4 dose schedule may be a better than 3-dose single vaccines for Indigenous and high-risk children. The vaccines' effects on immune response and on nasal colonisation with bacterial pathogens will be compared.