Investigation Of The Role Of Type II PI 3-kinases In Platelet Function
Funder
National Health and Medical Research Council
Funding Amount
$444,973.00
Summary
Inappropriate blood clot formation is the cause of most heart attacks and strokes, and platelets are the blood cells which form these clots. Current therapies that interfere with platelet function are used to prevent heart attack and stroke but are frequently ineffective. We will study the signals which control platelet incorporation into clots in order to discover improved therapeutic strategies for heart attack and stroke prevention.
Is Sympathetic Activation Beneficial Or Detrimental In Septic Shock?
Funder
National Health and Medical Research Council
Funding Amount
$458,755.00
Summary
Septic shock is a major cause of death in intensive care units. It is associated with large increases in sympathetic nerve activity to the heart and kidneys, which have both beneficial and harmful effects. This project will determine the responses to the increased sympathetic activity in septic shock, the causes of it and whether blocking this activation has an overall beneficial effect. This knowledge is essential before drugs that block sympathetic activation are examined in clinical studies.