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Improving plant productivity and human health using next generation biotechnology approaches. Both medical and plant sciences face similar technological problems in harnessing the power of modern DNA sequencing for accelerating the pace of beneficial gene function discovery. Plant and animal researchers will collaborate in this program to meet this common challenge. The research outcomes envisaged in this proposal will benefit human health by enabling more rapid discovery of genes related to obe ....Improving plant productivity and human health using next generation biotechnology approaches. Both medical and plant sciences face similar technological problems in harnessing the power of modern DNA sequencing for accelerating the pace of beneficial gene function discovery. Plant and animal researchers will collaborate in this program to meet this common challenge. The research outcomes envisaged in this proposal will benefit human health by enabling more rapid discovery of genes related to obesity, immunity, fertility, neurological function and cancer. In the plant sphere, the outcomes will shed new light on plant functions related to plant energy metabolism, vitamin biosynthesis drought tolerance and water use by crops. The research will benefit both human health and agricultural food production and quality.Read moreRead less
Extreme expression: building a platform for industrial plant biotechnology. Plants have remarkable potential as bioreactors for the production of usually non-plant compounds such as medical proteins, industrial proteins including enzymes and polymers. However, to realise this potential, there needs to be very significant advances in the amount of target compounds produced in the bioreactor plants and to develop other plant species as bioreactors. The aim of this project is to develop technologie ....Extreme expression: building a platform for industrial plant biotechnology. Plants have remarkable potential as bioreactors for the production of usually non-plant compounds such as medical proteins, industrial proteins including enzymes and polymers. However, to realise this potential, there needs to be very significant advances in the amount of target compounds produced in the bioreactor plants and to develop other plant species as bioreactors. The aim of this project is to develop technologies that provide the platform to produce large quantities of target novel compounds in plants and extend the range of plant species that can be used as bioreactors. These technologies will provide the basis of a dynamic biofarming industry in Australia.Read moreRead less
Nanoengineered Polymeric Materials for Environmental and Biological Applications. The development of advanced materials with nanoengineered properties promises to revolutionise future industries, including the energy and healthcare sectors. This research program will involve the design, synthesis and assembly of tailored polymers to prepare next-generation, engineered materials. The research will deliver advanced polymeric membranes, tissue engineering scaffolds and vaccine delivery systems. The ....Nanoengineered Polymeric Materials for Environmental and Biological Applications. The development of advanced materials with nanoengineered properties promises to revolutionise future industries, including the energy and healthcare sectors. This research program will involve the design, synthesis and assembly of tailored polymers to prepare next-generation, engineered materials. The research will deliver advanced polymeric membranes, tissue engineering scaffolds and vaccine delivery systems. These materials are expected to provide benefits for Australian citizens in the energy and health sectors and contribute to the development of a robust Australian nanotechnology industry. The projects will also provide opportunities for the development of outstanding young scientists and will foster multidisciplinary collaborations.Read moreRead less
Establishing the reference frame using astronomical and space-geodetic observations. Australia is increasingly dependent on spatial positioning and spatial data, yet mostly relies upon international agencies and research organisations to provide regular updates of coordinates and reference frame definition used on Earth. Improving the accuracy of the reference frame definition and our understanding of errors in the space-based measurements will provide new insights for studies of the Earth. The ....Establishing the reference frame using astronomical and space-geodetic observations. Australia is increasingly dependent on spatial positioning and spatial data, yet mostly relies upon international agencies and research organisations to provide regular updates of coordinates and reference frame definition used on Earth. Improving the accuracy of the reference frame definition and our understanding of errors in the space-based measurements will provide new insights for studies of the Earth. The research will yield results in studies of national significance, such as sea level rise, the effects of melting polar regions, and crustal deformation, as well as developing Australia's expertise in exploiting observations of the Earth from space.Read moreRead less
Novel dating methods for marine sediments of relevance to determining past climate changes. Future climate change is a subject of enormous contemporary interest with economic and social implications for much of humanity. Accurate knowledge of past climates is, however, crucial to understanding how the global climate will evolve into the future. This proposal aims to develop novel methods for dating marine sediments using cosmogenic isotopes, in order to extract the palaeoclimatic signals that ar ....Novel dating methods for marine sediments of relevance to determining past climate changes. Future climate change is a subject of enormous contemporary interest with economic and social implications for much of humanity. Accurate knowledge of past climates is, however, crucial to understanding how the global climate will evolve into the future. This proposal aims to develop novel methods for dating marine sediments using cosmogenic isotopes, in order to extract the palaeoclimatic signals that are locked into these sediments. We will concentrate on the Southern Ocean which plays a crucial role in the world's climate. This proposal will also contribute to Australia's international obligation to conduct research in this critical area.Read moreRead less
A fundamental study of electronic transport in advanced semiconductor nanostructures. The principal aim of this project is to attract and retain very high calibre early career researchers by providing them with the best-available infrastructure and research environment, combined with world-class supervision and mentoring. The project brings together an outstanding team of international collaborators, who will work with the early career researchers to ensure that they are trained and mentored at ....A fundamental study of electronic transport in advanced semiconductor nanostructures. The principal aim of this project is to attract and retain very high calibre early career researchers by providing them with the best-available infrastructure and research environment, combined with world-class supervision and mentoring. The project brings together an outstanding team of international collaborators, who will work with the early career researchers to ensure that they are trained and mentored at an international level. The new science, novel characterisation methods, and theoretical models that are outcomes of this project will provide new opportunities and expertise to advance the strategic defence and national security interests of Australia, and the emerging Australian semiconductor device and solar cell industry. Read moreRead less
Geophysical, Galactic, and Extra-Galactic Science with the AuScope and Australian Pathfinder Arrays. Two new radio telescope arrays are under construction in Australia. One is the Australian Square Kilometre Array Pathfinder, near Geraldton. The other is a very long baseline array with antennae near Hobart, Katherine, and Yarragadee. These three antennae work together to observe radio sources far away across the universe. Their observations are used to establish a very accurate coordinate syste ....Geophysical, Galactic, and Extra-Galactic Science with the AuScope and Australian Pathfinder Arrays. Two new radio telescope arrays are under construction in Australia. One is the Australian Square Kilometre Array Pathfinder, near Geraldton. The other is a very long baseline array with antennae near Hobart, Katherine, and Yarragadee. These three antennae work together to observe radio sources far away across the universe. Their observations are used to establish a very accurate coordinate system or reference frame on the earth, to which the global positioning system is aligned. This program will use these new radio telescope arrays to study the Milky Way and other galaxies, and to study continental drift and sea-level rise on the Earth.Read moreRead less
Accretion and Feedback in Galaxies with Cosmic Time. Australia is a world leader in both astronomy and photonics. This proposal seeks to exploit a revolutionary device that is the first developed from the new cross-over field of astrophotonics. The Gemini Near-infrared OH Suppression IFU System (GNOSIS) instrument will showcase Australian industry development in optical fibres and will keep Australian astronomers at the forefront of international research. This will lead to major advantages wh ....Accretion and Feedback in Galaxies with Cosmic Time. Australia is a world leader in both astronomy and photonics. This proposal seeks to exploit a revolutionary device that is the first developed from the new cross-over field of astrophotonics. The Gemini Near-infrared OH Suppression IFU System (GNOSIS) instrument will showcase Australian industry development in optical fibres and will keep Australian astronomers at the forefront of international research. This will lead to major advantages when developing future instrumentation for next generation telescopes such at the Giant Magellan Telescope, enabling Australia to continue to lead astronomy and astronomical instrumentation into the next decade and beyond.Read moreRead less
Nanoimaging the cellular architecture of the malaria parasite, Plasmodium falciparum. The immediate benefit of this work will be in the understanding and treatment of malaria - a disease that kills approximately 1 million children annually. The ability to image the three-dimensional structure of cells at high resolution will allow us to ask fundamental questions about the cellular architecture of the malaria parasite and to design novel antimalarial strategies. By developing new methods for cor ....Nanoimaging the cellular architecture of the malaria parasite, Plasmodium falciparum. The immediate benefit of this work will be in the understanding and treatment of malaria - a disease that kills approximately 1 million children annually. The ability to image the three-dimensional structure of cells at high resolution will allow us to ask fundamental questions about the cellular architecture of the malaria parasite and to design novel antimalarial strategies. By developing new methods for correlating structure and elemental location, the work in this proposal will offer a new paradigm for the study of cellular function and disease. This represents an important advance in the suite of investigative tools available to the biotechology sector and will see a corresponding improvement in our understanding of a wide range of disease states.Read moreRead less
Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technologica ....Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technological potential as commercially relevant research tools.Read moreRead less