Developing next generation click chemistry. This project aims to develop next generation click chemistry as an enabling synthetic technology for creating functional molecules. Click-philosophy, that 'all searches must be restricted to molecules that are easy to make', is a key requirement for rapid discovery of useful functional materials, medicines and molecular tools. Click linkers make this possible, and the project will develop a new range of asymmetric 3D-Connectors based upon readily avail ....Developing next generation click chemistry. This project aims to develop next generation click chemistry as an enabling synthetic technology for creating functional molecules. Click-philosophy, that 'all searches must be restricted to molecules that are easy to make', is a key requirement for rapid discovery of useful functional materials, medicines and molecular tools. Click linkers make this possible, and the project will develop a new range of asymmetric 3D-Connectors based upon readily available, yet unexplored main group gasses, and will demonstrate their usefulness in several applications including the synthesis of new polymers. The project will also develop the first general asymmetric Click reaction, which will have significant impact in biological applications and materials science. This project will result in the development of new synthetic chemistry technology that will have a global impact, which will add value to the knowledge economy of Australia and contribute skills and training to the next generation of Australian scientists.Read moreRead less
New materials for manipulating intracellular communication. This project aims to identify new techniques for incorporating cell-signalling triggers into macromolecules, therefore enabling the development of next-generation stimuli-responsive nanoparticles that can emit signalling molecules on demand. Harnessing nanomaterials to stimulate specific sub-cellular processes is a neglected area in nanotechnology research. These nanoparticles could potentially be used to deliver signalling molecules fo ....New materials for manipulating intracellular communication. This project aims to identify new techniques for incorporating cell-signalling triggers into macromolecules, therefore enabling the development of next-generation stimuli-responsive nanoparticles that can emit signalling molecules on demand. Harnessing nanomaterials to stimulate specific sub-cellular processes is a neglected area in nanotechnology research. These nanoparticles could potentially be used to deliver signalling molecules for agricultural, pharmaceutical and veterinary applications. The project is expected to develop a new suite of materials that could ultimately be used to improve the yield of important commercial crops, or revitalise the use of medicines limited by their poor side effect profile.Read moreRead less
Expanding the toolbox of synthetic stealth polymers. This project aims to develop a new generation of synthetic and biomimetic pseudo peptide polymers with advanced biomedical properties. The polymers will be used for the fabrication of a range of nanoparticles, which will allow to study the effect of architecture, composition and surface functionalisation on their behaviour in a biological environment. Carefully conducted structure-physicochemical property relationship and bio-nano interaction ....Expanding the toolbox of synthetic stealth polymers. This project aims to develop a new generation of synthetic and biomimetic pseudo peptide polymers with advanced biomedical properties. The polymers will be used for the fabrication of a range of nanoparticles, which will allow to study the effect of architecture, composition and surface functionalisation on their behaviour in a biological environment. Carefully conducted structure-physicochemical property relationship and bio-nano interaction studies will generate new knowledge in the area of stealth and protein repellent nanomaterials. The intended outcome of the project is the generation of a platform of bioinert materials that could potentially find applications as building blocks in next generation nanomedicines and medical devices.Read moreRead less
Stereolithographic Additive Manufacturing of Semicrystalline Thermoplastics. This project aims to advance the development of high-throughput stereolithographic additive manufacturing of thermoplastic polymers and composites by employing a multi-colour irradiation schemes in conjunction with photopolymerisable, ring-opening monomer resin formulations. The fundamental scientific understanding, engineering expertise, and concomitant technology advances generated by this project are anticipated to e ....Stereolithographic Additive Manufacturing of Semicrystalline Thermoplastics. This project aims to advance the development of high-throughput stereolithographic additive manufacturing of thermoplastic polymers and composites by employing a multi-colour irradiation schemes in conjunction with photopolymerisable, ring-opening monomer resin formulations. The fundamental scientific understanding, engineering expertise, and concomitant technology advances generated by this project are anticipated to enable additive manufacturing to transition from the rapid prototyping of individual, unique items to the high volume production of robust, reprocessable plastic parts. By obviating the large capital expense of conventional fabrication, this developed technology should provide a path to reinvigorate Australian manufacturing.Read moreRead less
Aluminium at the centre of sustainable catalysis. The project aims to establish new directions in the field of Lewis acid catalysis by creating a unique set of aluminium compounds. As catalysis is an important principle of green chemistry and as aluminium is the most abundant metal in the Earth's crust (i.e. sustainable), the project's aims are exceptionally well aligned with the society's targets to alleviate the negative effects of human activities on the environment. Expected outcomes of this ....Aluminium at the centre of sustainable catalysis. The project aims to establish new directions in the field of Lewis acid catalysis by creating a unique set of aluminium compounds. As catalysis is an important principle of green chemistry and as aluminium is the most abundant metal in the Earth's crust (i.e. sustainable), the project's aims are exceptionally well aligned with the society's targets to alleviate the negative effects of human activities on the environment. Expected outcomes of this project include significant advances related to industrially relevant processes, potentially degradable polymers and valorisation of the most prevalent greenhouse gas. Thus, the overall project should provide significant benefit to our collective efforts to mediate human impact on climate change.Read moreRead less