Mimicking the perivascular niche with boronolectin-based biomaterials. This project aims to address roadblocks in perivascular stem cell manufacturing by discovering novel mechanisms and materials that improve cell quality outcomes during extended culture. An innovative, interdisciplinary approach to biomaterials discovery, combining live cell-based screening of cell surface glycans, bio-inspired materials design and synthesis, and niche mimicry, will enable the discovery of cell surface glycan- ....Mimicking the perivascular niche with boronolectin-based biomaterials. This project aims to address roadblocks in perivascular stem cell manufacturing by discovering novel mechanisms and materials that improve cell quality outcomes during extended culture. An innovative, interdisciplinary approach to biomaterials discovery, combining live cell-based screening of cell surface glycans, bio-inspired materials design and synthesis, and niche mimicry, will enable the discovery of cell surface glycan-mediated interactions that support long-term expansion and potency maintenance, and synthetic biomaterials that can mimic them. Significant benefits for stem cell researchers, manufacturers and end users are expected from the project and the application of this scalable biomaterial platform.Read moreRead less
On-demand 3D polymer scaffolds for directed stem cell differentiation. The project will develop new polymer gels that can be sculpted into shapes, representing tissues and organs. This 3D scaffold will provide a surface with biological signals to create functional tissues from stem cells. The approach will create engineered intestinal tissue with great promise to increase the survival rates of colon cancer patients.
Vesicles stabilised by compressed carbon dioxide as nanoreactors and templates for radical polymerisation. A new environmentally friendly method for synthesis of surfactant vesicles involving stabilisation using low pressure carbon dioxide will be applied to the synthesis of hollow polymeric nanoparticles and polymer of well-defined structure. The resulting polymeric structures will have applications in drug delivery and nano-engineered materials.
Programming the Microstructure of 3D Printed Objects . This project aims to apply state-of-the-art living polymerisation techniques to 3D printing to efficiently produce customised polymer materials that are tailored at the molecular level. By combining computational modeling and experimental approach, fast and oxygen tolerant photoliving radical polymerisation will be developed and applied to 3D printing. These new systems will produce highly structured polymer materials with remarkable mechani ....Programming the Microstructure of 3D Printed Objects . This project aims to apply state-of-the-art living polymerisation techniques to 3D printing to efficiently produce customised polymer materials that are tailored at the molecular level. By combining computational modeling and experimental approach, fast and oxygen tolerant photoliving radical polymerisation will be developed and applied to 3D printing. These new systems will produce highly structured polymer materials with remarkable mechanical properties. The effect of nanostructure on the macroscopic material properties will be investigated. The intended outcome of this project will produce advanced materials with tailored mechanical properties via streamlined and accessible approaches.Read moreRead less
Precision-built dynamic and functional polymer vesicles. The project aims to create new precision-built polymer vesicles with controlled size, stability, functionality and environmental responsiveness to mimic some of the key dynamic functions of the cell. The project expects to generate new knowledge on the dynamic interplay between the polymer and its bilayer including on-demand activated polymerisations and reactions, logic gates and in situ sensors. Expected outcomes of this project include ....Precision-built dynamic and functional polymer vesicles. The project aims to create new precision-built polymer vesicles with controlled size, stability, functionality and environmental responsiveness to mimic some of the key dynamic functions of the cell. The project expects to generate new knowledge on the dynamic interplay between the polymer and its bilayer including on-demand activated polymerisations and reactions, logic gates and in situ sensors. Expected outcomes of this project include new synthetic polymer techniques and new quantitative insights into the role of compartmentalisation on chemical reactions and polymerisations. This project will provide fundamental knowledge on bio/polymer vesicles with great potential to advance the polymer industry in Australia.Read moreRead less
Precision porous polymer microparticles via integrated flow processes. This project aims at a step-change in functional, porous microparticle manufacture. To achieve this, the project will use precision flow chemistry techniques that will integrate emulsion preparation, microparticle production and chemical functionalisation in one continuous process. The expected outcome of the project is a process for the manufacture of a suite of designer porous polymer microparticles. Expected benefits are d ....Precision porous polymer microparticles via integrated flow processes. This project aims at a step-change in functional, porous microparticle manufacture. To achieve this, the project will use precision flow chemistry techniques that will integrate emulsion preparation, microparticle production and chemical functionalisation in one continuous process. The expected outcome of the project is a process for the manufacture of a suite of designer porous polymer microparticles. Expected benefits are disruptive advances in a number of key technological sectors, including biomedicine, pharmacy, energy and bioprocessing. Platform technology for cartilage tissue engineering has been chosen as an exemplar of the power of precision microparticles.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100097
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Advanced characterisation of materials by nuclear magnetic resonance. Advanced characterisation of materials by nuclear magnetic resonance will support a broad range of research possibilities for development of advanced materials for medical, industrial and environmental applications. Details of molecular structure and mobility will be uncovered which will provide guidance for making improvements to new and existing materials.