Mimicking the perivascular niche with boronolectin-based biomaterials. This project aims to address roadblocks in perivascular stem cell manufacturing by discovering novel mechanisms and materials that improve cell quality outcomes during extended culture. An innovative, interdisciplinary approach to biomaterials discovery, combining live cell-based screening of cell surface glycans, bio-inspired materials design and synthesis, and niche mimicry, will enable the discovery of cell surface glycan- ....Mimicking the perivascular niche with boronolectin-based biomaterials. This project aims to address roadblocks in perivascular stem cell manufacturing by discovering novel mechanisms and materials that improve cell quality outcomes during extended culture. An innovative, interdisciplinary approach to biomaterials discovery, combining live cell-based screening of cell surface glycans, bio-inspired materials design and synthesis, and niche mimicry, will enable the discovery of cell surface glycan-mediated interactions that support long-term expansion and potency maintenance, and synthetic biomaterials that can mimic them. Significant benefits for stem cell researchers, manufacturers and end users are expected from the project and the application of this scalable biomaterial platform.Read moreRead less
On-demand 3D polymer scaffolds for directed stem cell differentiation. The project will develop new polymer gels that can be sculpted into shapes, representing tissues and organs. This 3D scaffold will provide a surface with biological signals to create functional tissues from stem cells. The approach will create engineered intestinal tissue with great promise to increase the survival rates of colon cancer patients.
Precision-built dynamic and functional polymer vesicles. The project aims to create new precision-built polymer vesicles with controlled size, stability, functionality and environmental responsiveness to mimic some of the key dynamic functions of the cell. The project expects to generate new knowledge on the dynamic interplay between the polymer and its bilayer including on-demand activated polymerisations and reactions, logic gates and in situ sensors. Expected outcomes of this project include ....Precision-built dynamic and functional polymer vesicles. The project aims to create new precision-built polymer vesicles with controlled size, stability, functionality and environmental responsiveness to mimic some of the key dynamic functions of the cell. The project expects to generate new knowledge on the dynamic interplay between the polymer and its bilayer including on-demand activated polymerisations and reactions, logic gates and in situ sensors. Expected outcomes of this project include new synthetic polymer techniques and new quantitative insights into the role of compartmentalisation on chemical reactions and polymerisations. This project will provide fundamental knowledge on bio/polymer vesicles with great potential to advance the polymer industry in Australia.Read moreRead less