Metabolomic and genetic approaches to the discovery of genes that direct carbon partitioning in plants. Plants make starch, sucrose, cell walls (fibre), oil, organic acids, vitamins and other products of great economic and social importance. The partitioning of carbon resources into such products determines crop productivity and quality. This partitioning is strongly influenced by nutrients, water and salinity. The powerful genomics resources of Arabidopsis including the new discipline of metabo ....Metabolomic and genetic approaches to the discovery of genes that direct carbon partitioning in plants. Plants make starch, sucrose, cell walls (fibre), oil, organic acids, vitamins and other products of great economic and social importance. The partitioning of carbon resources into such products determines crop productivity and quality. This partitioning is strongly influenced by nutrients, water and salinity. The powerful genomics resources of Arabidopsis including the new discipline of metabolomics, will be deployed to understand the regulation of carbon partitioning in leaves and to discover genes that direct partitioning. National research capability will be enhanced and new resources will be generated to breed crops with improved yield potential and product quality under varied environmental conditions.Read moreRead less
Salinity tolerance and long-distance transport in cereals. The aim of this program is to alter shoot accumulation of solutes in cereals by exploiting novel transgenic technology to manipulate processes in specific cell types in the roots. The primary objective is the generation of cereals which have increased tolerance of saline soils. This is clearly of much agricultural significance in Australia. More general outcomes include the generation of plants with altered concentrations of a range of n ....Salinity tolerance and long-distance transport in cereals. The aim of this program is to alter shoot accumulation of solutes in cereals by exploiting novel transgenic technology to manipulate processes in specific cell types in the roots. The primary objective is the generation of cereals which have increased tolerance of saline soils. This is clearly of much agricultural significance in Australia. More general outcomes include the generation of plants with altered concentrations of a range of nutrients in both leaves and grain. This will be of wide agricultural and nutritional benefit, as well as providing an understanding of principles underlying the long-distance co-ordination of processes in plants.Read moreRead less
The first stage of vision: transduction and adaptation in retinal photoreceptors. The project aims to provide a detailed understanding of the molecular steps involved in the first stage of vision - the conversion of light into a neural signal in the rod and cone photoreceptors of the retina. The significance of this is that it will explain the initial events that enable us to see, and will help explain the deficits that occur when the process fails. The outcome will be a comprehensive understand ....The first stage of vision: transduction and adaptation in retinal photoreceptors. The project aims to provide a detailed understanding of the molecular steps involved in the first stage of vision - the conversion of light into a neural signal in the rod and cone photoreceptors of the retina. The significance of this is that it will explain the initial events that enable us to see, and will help explain the deficits that occur when the process fails. The outcome will be a comprehensive understanding of how our photoreceptors respond with extreme sensitivity, yet great rapidity, and over an enormous range of light intensities, thus endowing us with our remarkable sense of vision.Read moreRead less
Small RNAs: what makes a plant, a plant. Understanding the roles of small RNAs and their pathways is a young field of research that is giving, and will continue to give, profound insights into how multicellular organisms regulate gene expression at a genomic level. Research in this area has already led to RNA interference technology, by which almost any gene can be switched off, and there is considerable potential for other gene silencing and trait modification technologies to emerge. The projec ....Small RNAs: what makes a plant, a plant. Understanding the roles of small RNAs and their pathways is a young field of research that is giving, and will continue to give, profound insights into how multicellular organisms regulate gene expression at a genomic level. Research in this area has already led to RNA interference technology, by which almost any gene can be switched off, and there is considerable potential for other gene silencing and trait modification technologies to emerge. The project will yield insights into fundamental biological processes which are expected to engender applications in agriculture and biotechnology. It will maintain and enhance Australia's position in this area.Read moreRead less
Integrative behaviour: a new synthesis. The research will use a uniquely integrative behavioural approach to a) analyse swarming in locusts, and b) apply powerful new models in nutrition to address key problems in biology, agriculture and human health. Outcomes will include i) an understanding of the molecular and environmental mechanisms controlling swarming in locusts, providing new management and control strategies; ii) insights into human obesity, with health policy recommendations; iii) new ....Integrative behaviour: a new synthesis. The research will use a uniquely integrative behavioural approach to a) analyse swarming in locusts, and b) apply powerful new models in nutrition to address key problems in biology, agriculture and human health. Outcomes will include i) an understanding of the molecular and environmental mechanisms controlling swarming in locusts, providing new management and control strategies; ii) insights into human obesity, with health policy recommendations; iii) new technologies for designing nutritional regimes for animal production; iv) an understanding of the responses of insect pests to changing environments; and v) insights into the flow of nutrients across trophic levels within terrestrial ecosystems.Read moreRead less
How organisms coordinate energy supply and demand. The metabolic stress sensing protein kinase called the AMP activated protein kinase controls metabolism of all eukaryotes to meet the needs of energy demand and nutrient supply. It is responsible for accelerating metabolism (glucose transport, glycolysis and fatty acid oxidation) in response to energy demand and with caloric restriction it regulates gene transcription to adapt to energy supply. This project is to provide a comprehensive unders ....How organisms coordinate energy supply and demand. The metabolic stress sensing protein kinase called the AMP activated protein kinase controls metabolism of all eukaryotes to meet the needs of energy demand and nutrient supply. It is responsible for accelerating metabolism (glucose transport, glycolysis and fatty acid oxidation) in response to energy demand and with caloric restriction it regulates gene transcription to adapt to energy supply. This project is to provide a comprehensive understanding of the AMP activated protein kinase (enzyme isoforms, genes, physiological roles and regulation). This knowledge will have major benefits in biopharmaceutical development, the livestock, plant and sport/racing industries.Read moreRead less