Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100225
Funder
Australian Research Council
Funding Amount
$410,000.00
Summary
Western Australia single-cell isolation and genomics preparation facility. This project aims to give Western Australian researchers direct access to new platforms in single-cell isolation and single-cell RNA, genome and exome sample library preparation, so they can participate in the precision single-cell based research driving biology worldwide. This project will give researchers access to single-cell analysis techniques, integrated with other analysis methods, microscopy, and preclinical imagi ....Western Australia single-cell isolation and genomics preparation facility. This project aims to give Western Australian researchers direct access to new platforms in single-cell isolation and single-cell RNA, genome and exome sample library preparation, so they can participate in the precision single-cell based research driving biology worldwide. This project will give researchers access to single-cell analysis techniques, integrated with other analysis methods, microscopy, and preclinical imaging. The characterisation of rare and complex biological samples is expected to advance effective, socio-economically important research programmes in cell and molecular biology, sports science, plant and crop sciences, agriculture, clean energy (biofuels) resources and production, greenhouse gas reduction, environmental microbiology and marine science.Read moreRead less
TraitCapture: Genomic modelling for plant phenomics under environmental stress. This project aims to develop software to integrate new hyper-spectral and 3D growth models of plant phenomics with population genomics to identify heritable developmental traits across varied environments. Genome wide association studies aim to then be used to identify causal genes. Functional structural plant models incorporating genetic variation will be used to predict growth under simulated stress environments. ....TraitCapture: Genomic modelling for plant phenomics under environmental stress. This project aims to develop software to integrate new hyper-spectral and 3D growth models of plant phenomics with population genomics to identify heritable developmental traits across varied environments. Genome wide association studies aim to then be used to identify causal genes. Functional structural plant models incorporating genetic variation will be used to predict growth under simulated stress environments. The research team unites international industry, the Australian Plant Phenomics Facility, and university statistical geneticists. TraitCapture software will use open standards applicable to both controlled and field environments enabling plant breeders to pre-select adaptive traits to increase crop productivity under environmental stress.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100460
Funder
Australian Research Council
Funding Amount
$380,000.00
Summary
Role of DNA methylation in response to low nutrient availability in plants. DNA methylation (mC) is a covalent modification of DNA essential for the establishment and maintenance of correct gene expression patterns and recently suggested to be responsive to some environmental cues in plants. Using cutting edge technologies, this project aims to identify nutrient stress-induced mC changes and investigate the role that these changes may play in transcriptional regulation, as well as assessing whet ....Role of DNA methylation in response to low nutrient availability in plants. DNA methylation (mC) is a covalent modification of DNA essential for the establishment and maintenance of correct gene expression patterns and recently suggested to be responsive to some environmental cues in plants. Using cutting edge technologies, this project aims to identify nutrient stress-induced mC changes and investigate the role that these changes may play in transcriptional regulation, as well as assessing whether these changes can be transmitted to the next generation to confer intergenerational stress responsiveness. Altogether this project aims to provide fundamental knowledge of the role of mC in plant gene regulation and stress response as well as paving the way for the next generation of novel crop-improvement strategies.Read moreRead less
The role of chlorophyll f in photosynthesis. The knowledge of energetic limits of oxygenic photosynthesis will provide opportunities for improving the efficiency of photosynthesis by using a wider range of the solar spectrum. This project aims to understand the roles of newly discovered chlorophyll f in central photoreactions and its biosynthesis.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100130
Funder
Australian Research Council
Funding Amount
$850,000.00
Summary
Systems biology: New generation DNA sequencing to functional analysis. The technique of DNA sequencing (or 'reading' the lines of the four repeating letters that make up the genetic code) illustrates how technological developments have become the main drivers in exploring the roles of genetic factors across a spectrum of research activities. Funding provided through this ARC grant will allow the purchase of the latest DNA sequencing platform, the Illumina Solexa, as well as equipment that will b ....Systems biology: New generation DNA sequencing to functional analysis. The technique of DNA sequencing (or 'reading' the lines of the four repeating letters that make up the genetic code) illustrates how technological developments have become the main drivers in exploring the roles of genetic factors across a spectrum of research activities. Funding provided through this ARC grant will allow the purchase of the latest DNA sequencing platform, the Illumina Solexa, as well as equipment that will be used to understand the biological function of the DNA sequencing results that are obtained. The equipment will allow Australian researchers to compete on an equal footing with the international leaders in understanding the roles played by genes in plants, microorganisms, animals and humans.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100038
Funder
Australian Research Council
Funding Amount
$654,000.00
Summary
Single cell genomics. This facility will allow us to discover the complete DNA sequence of an organism from as little material as a single cell. This equipment will allow Australian researchers to compete on an equal footing with international leaders in understanding the roles of genes in plants, bacteria, animals and humans.
Understanding disease resistance gene evolution across the Brassicaceae. Pan genomes represent the diversity of a species, including structural and sequence variation, which cannot be provided by a reference genome alone. In this project we will characterise resistance gene diversity across the Brassicaceae pan genomes. Through comparison with resistance gene diversity in cultivated Brassica species we will understand selection underlying resistance gene evolution in wild species and subsequent ....Understanding disease resistance gene evolution across the Brassicaceae. Pan genomes represent the diversity of a species, including structural and sequence variation, which cannot be provided by a reference genome alone. In this project we will characterise resistance gene diversity across the Brassicaceae pan genomes. Through comparison with resistance gene diversity in cultivated Brassica species we will understand selection underlying resistance gene evolution in wild species and subsequent domestication and breeding. Knowledge on how variation affects disease susceptibility, especially to the devastating fungal pathogen blackleg, and contributes to phenotypic variation, will lead to improved plant protection strategies and increased crop resilience.Read moreRead less
The More the Merrier? Investigating copy number variation in Brassicas. This project intends to develop an understanding of how gene copy number variation affects disease susceptibility to help in the design of novel plant protection strategies. Gene copy number variants (CNVs) are segments of DNA that have been duplicated or lost in the genome of one individual or line with respect to another. CNVs have been shown to contribute significantly to phenotypic differences in humans, including diseas ....The More the Merrier? Investigating copy number variation in Brassicas. This project intends to develop an understanding of how gene copy number variation affects disease susceptibility to help in the design of novel plant protection strategies. Gene copy number variants (CNVs) are segments of DNA that have been duplicated or lost in the genome of one individual or line with respect to another. CNVs have been shown to contribute significantly to phenotypic differences in humans, including disease susceptibility, and the same seems to apply in plants. This project aims to apply the genome sequences for Brassica species to detect CNVs from re-sequencing data. Knowing how this variation affects an individual or line’s disease susceptibility, especially to the devastating fungal pathogen blackleg, could improve plant protection strategies and crop production.Read moreRead less
The transgenerational effect of thermosensing in plants. This project aims to understand how thermosensing mechanisms in plants result in transgenerational change, and potentially adaptation to climate. Exploiting the recent discovery of the thermosensor phytochrome B, this project will decipher the molecular cascade which, either through long-distance communication or through persistence of an epigenetic state in the cell lineage, could lead to a trans generational memory in plants helping with ....The transgenerational effect of thermosensing in plants. This project aims to understand how thermosensing mechanisms in plants result in transgenerational change, and potentially adaptation to climate. Exploiting the recent discovery of the thermosensor phytochrome B, this project will decipher the molecular cascade which, either through long-distance communication or through persistence of an epigenetic state in the cell lineage, could lead to a trans generational memory in plants helping with climate adaptation. This project will unravel novel molecular mechanisms, which have the potential to pave the way for designing new climate-proofing solutions to cope with temperature uncertainty.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100249
Funder
Australian Research Council
Funding Amount
$391,743.00
Summary
Molecular systems biology of novel flower colour evolution. This project aims to discover new and potentially useful structural and regulatory genes while advancing knowledge of the chemical, genetic and ecological basis of unique evolutionary flower colour shifts. Dramatic shifts in floral colour is widespread in flowering plants, however, just how changes in flower colour occur remains poorly understood. This project will take advantage of unique Australian plants to investigate the molecular ....Molecular systems biology of novel flower colour evolution. This project aims to discover new and potentially useful structural and regulatory genes while advancing knowledge of the chemical, genetic and ecological basis of unique evolutionary flower colour shifts. Dramatic shifts in floral colour is widespread in flowering plants, however, just how changes in flower colour occur remains poorly understood. This project will take advantage of unique Australian plants to investigate the molecular mechanisms and evolutionary shift in flower colour changes. This project expects to advance knowledge on plant specialised metabolism with potential contributions to the floriculture, food and flavour industries.Read moreRead less