Understanding the evolution of fungicide resistance for durable control of fungal pathogens in pyrethrum. The pyrethrum plant is grown for the extraction of natural insecticidal pyrethrins used in a variety of pest control products. Australia supplies 60 per cent of the global market for natural pyrethrins. Fungal pathogens of pyrethrum can cause severe losses. This project will investigate fungicide resistance in these pathogens at the molecular level.
Development of a risk management system for systemic downy mildew of poppies. Development of a risk management system for systemic downy mildew of poppies. This project aims to identify the critical inoculum sources of systemic downy mildew—a new disease threat to the Australian poppy industry, which produces over half the world’s medicinal opiates. It will assess these sources’ relative importance and interaction with agronomic site factors in epidemics; and also intends to understand the syste ....Development of a risk management system for systemic downy mildew of poppies. Development of a risk management system for systemic downy mildew of poppies. This project aims to identify the critical inoculum sources of systemic downy mildew—a new disease threat to the Australian poppy industry, which produces over half the world’s medicinal opiates. It will assess these sources’ relative importance and interaction with agronomic site factors in epidemics; and also intends to understand the systemic progression in planta, an area poorly understood in all downy mildew pathosystems. The project expects the data will form the basis of a disease risk index tool to educate growers and guide disease management strategies essential to this industry’s long term viability.Read moreRead less
How scissors learn to glue: the catalysis of ligation by proteases. This project proposes to study protein-cutting enzymes from plants that are drawn into biosyntheses where they paradoxically perform protein-joining (ligation) reactions. Enzymes are everywhere, from detergents to digestion to detoxifying drugs. Industry uses artificial evolution to improve enzymes or create enzymes with new activities. By exploring the changes that allowed one such cutting enzyme to ligate, the knowledge acquir ....How scissors learn to glue: the catalysis of ligation by proteases. This project proposes to study protein-cutting enzymes from plants that are drawn into biosyntheses where they paradoxically perform protein-joining (ligation) reactions. Enzymes are everywhere, from detergents to digestion to detoxifying drugs. Industry uses artificial evolution to improve enzymes or create enzymes with new activities. By exploring the changes that allowed one such cutting enzyme to ligate, the knowledge acquired may enable protein engineering to develop designer enzymes with enhanced or suppressed ligating ability. Although protein evolution can be studied with artificial systems, natural systems are extremely valuable. Insights from studying this natural evolution of ligation may test hypotheses developed with data from artificial evolution.Read moreRead less
How do sunflowers make protein drugs in their seeds? We recently discovered in sunflower the origin of a small protein ring that chemists have used for a decade to base designed drugs upon. This project aims to know how sunflowers make it so we may manipulate other plants to manufacture ring-based drugs.
Australian Laureate Fellowships - Grant ID: FL160100155
Funder
Australian Research Council
Funding Amount
$2,715,383.00
Summary
Harmonising genes for modern agriculture. Harmonising genes for modern agriculture. This project aims to fully understand how a plant distinguishes self from non-self genes and to develop ways of precisely enhancing, repairing, updating, and/or redirecting genetic traits in harmony with the genome. The world’s food security relies on modern crops that are continually updated with genetic traits for higher yield and protection against changing environmental stresses. A crop plant’s genes determin ....Harmonising genes for modern agriculture. Harmonising genes for modern agriculture. This project aims to fully understand how a plant distinguishes self from non-self genes and to develop ways of precisely enhancing, repairing, updating, and/or redirecting genetic traits in harmony with the genome. The world’s food security relies on modern crops that are continually updated with genetic traits for higher yield and protection against changing environmental stresses. A crop plant’s genes determine its growth, development, survival and agronomic fitness. The ability to precisely edit genes in crop plants is tantalizingly close but significant barriers must be overcome. Anticipated outcomes are safer, higher yielding and more sustainable crops.Read moreRead less
Production and testing of novel bioactive honeys and honey-based cosmetic formulations. The purpose of this project is to evaluate the entire spectrum of plant bioactive compounds that are transferred to the honey and develop novel bioactive honeys with enhanced antimicrobial, antioxidant and anti-inflammatory properties. This project will also develop new honey-based cosmetic products like creams, gels and foams.
Early Career Industry Fellowships - Grant ID: IE230100443
Funder
Australian Research Council
Funding Amount
$463,971.00
Summary
Pyrethrum in half the time: genes and systems to annually crop a perennial. The capacity of the Australian pyrethrum industry, the global leader in the supply of the natural insecticide, is threatened by the profitability of the current 18-month crop cycle. The project aims to transform the crop to an annual production cycle by discovering genes that underpin flower timing and yield. The project will generate new knowledge on the genetic and physiological drivers of flowering and exploit these f ....Pyrethrum in half the time: genes and systems to annually crop a perennial. The capacity of the Australian pyrethrum industry, the global leader in the supply of the natural insecticide, is threatened by the profitability of the current 18-month crop cycle. The project aims to transform the crop to an annual production cycle by discovering genes that underpin flower timing and yield. The project will generate new knowledge on the genetic and physiological drivers of flowering and exploit these for the development of viable 10-month crops. Outcomes of the project include new protocols and germplasm for breeding and managing short cycle crops for optimum yield. This will provide significant benefits including an economically attractive crop option for growers and a more sustainable industry. Read moreRead less
Practical application of gene silencing: is delivery of long double stranded ribonucleic acid (dsRNA) by plant cells efficient in conferring host resistance to parasitic nematodes? Nematode that attack plants cause $120 billion of crop losses worldwide. Chemicals used for their control are being phased out because of environmental concerns, and natural resistance is limited. The aim of this project is to use Australian IP to develop a new form of resistance to nematodes based on knowledge of th ....Practical application of gene silencing: is delivery of long double stranded ribonucleic acid (dsRNA) by plant cells efficient in conferring host resistance to parasitic nematodes? Nematode that attack plants cause $120 billion of crop losses worldwide. Chemicals used for their control are being phased out because of environmental concerns, and natural resistance is limited. The aim of this project is to use Australian IP to develop a new form of resistance to nematodes based on knowledge of the host-pathogen interactions. A successful outcome could contribute an additional 5-20% increase in crop yields (depending on the crop) through inherent resistance of crops to nematode pests. This would benefit rural communities and the national economy, and could also generate international royalties.Read moreRead less
The response of mitochondria to oxidative stress in plants. Crops encounter many situations in their environment which place them under stress. Reactive oxygen molecules produced in these situations act as messengers to trigger defence mechanisms but also cause cellular damage. Mitochondria are the subcellular compartments involved in energy production and are essential for plant development and growth. However, they also have been implicated in the response of plants to stress and pathogen atta ....The response of mitochondria to oxidative stress in plants. Crops encounter many situations in their environment which place them under stress. Reactive oxygen molecules produced in these situations act as messengers to trigger defence mechanisms but also cause cellular damage. Mitochondria are the subcellular compartments involved in energy production and are essential for plant development and growth. However, they also have been implicated in the response of plants to stress and pathogen attack, and in production of reactive oxygen molecules. This proposal seeks to investigate how mitochondria are involved in these processes, focusing on the role of terminal oxidases. Potential outcomes include crops better able to cope with environmental stress.Read moreRead less
A novel method of broad-acre weed seedbank management using a naturally occuring germination stimulant. The discovery of a novel butenolide that promotes seed germination has potential to provide significant economic benefits for Australia's agricultural sector, providing a vehicle to move towards minimum-weed agricultural systems achieved through broad-acre stimulation of the weed seedbank. Our aim is for butenolide to promote uniform release of weed seed dormancy, increased germination, and gr ....A novel method of broad-acre weed seedbank management using a naturally occuring germination stimulant. The discovery of a novel butenolide that promotes seed germination has potential to provide significant economic benefits for Australia's agricultural sector, providing a vehicle to move towards minimum-weed agricultural systems achieved through broad-acre stimulation of the weed seedbank. Our aim is for butenolide to promote uniform release of weed seed dormancy, increased germination, and greater synchrony in early stage seedling growth and thus more effective knock-down following herbicide applications.Read moreRead less