Neurons isolated from embryonic stem cells as functional models for drug discovery. By using gene expression-based selection criteria embryonic stem cells can be driven to differentiate into specific neuronal lineages which show many of the morphological characteristics and immunocytochemical features of neurons in culture. There is, however, comparatively little evidence indicating that these stem cell-derived neurons actually behave as neurons. Our aim is to characterise and contrast four ne ....Neurons isolated from embryonic stem cells as functional models for drug discovery. By using gene expression-based selection criteria embryonic stem cells can be driven to differentiate into specific neuronal lineages which show many of the morphological characteristics and immunocytochemical features of neurons in culture. There is, however, comparatively little evidence indicating that these stem cell-derived neurons actually behave as neurons. Our aim is to characterise and contrast four neuronal cell cultures established with gene-based selection criteria. These cultures will be characterised by gene expression, immunocytochemistry, radiolabelled neurotransmitter release, electrophysiology and Ca2+ imaging studies. This study will highlight the functional effects of gene selection procedures upon stem cell-derived neurons.Read moreRead less
Seeing without eyes: the evolution of non-visual photoreceptors in vertebrates. Australia's underwater biodiversity is second to none with endemic species representing the earliest stages in vertebrate evolution, many of them relying heavily on vision for survival. Tracing the evolution of light detection and image formation will provide crucial information about the lifestyles of our vertebrate ancestors, the environmental selection pressures driving speciation and colour communication. Charact ....Seeing without eyes: the evolution of non-visual photoreceptors in vertebrates. Australia's underwater biodiversity is second to none with endemic species representing the earliest stages in vertebrate evolution, many of them relying heavily on vision for survival. Tracing the evolution of light detection and image formation will provide crucial information about the lifestyles of our vertebrate ancestors, the environmental selection pressures driving speciation and colour communication. Characterisation of optimal light environments and extra-ocular light detection will also help protect and manage endemic species in wild and captive environments. Read moreRead less
ARC Research Network for Advanced Materials. Materials science/engineering is decidedly interdisciplinary, covering all science and impacting on all manufacturing industry. This network will promote interactions that do not usually occur between materials researchers and students across Australia and internationally from diverse disciplines. The scope is broadly based on advanced materials production, processing and properties but focused in four areas, involving: i) innovative structural/functi ....ARC Research Network for Advanced Materials. Materials science/engineering is decidedly interdisciplinary, covering all science and impacting on all manufacturing industry. This network will promote interactions that do not usually occur between materials researchers and students across Australia and internationally from diverse disciplines. The scope is broadly based on advanced materials production, processing and properties but focused in four areas, involving: i) innovative structural/functional materials, ii) high-tech IT/communications/sensing materials, iii) materials solutions for manufacturing, iv) materials for a sustainable Australia, and v) emerging materials technologies. Key programs will promote interdisciplinary workshops and early career researcher interactions.Read moreRead less
Special Research Initiatives - Grant ID: SR0354605
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
The Earth System Dynamics Network for a Sustainable Australia. Earth comprises systems of enormous complexity that sustain all life and control the distribution of mineral, energy and water resources. Thus understanding these dynamic systems provides the key to sustainable resource usage. The aim of The Earth System Dynamics Network is to facilitate scientific interactions through establishment of an earth and environmental sciences grid that links national and regional data assets with high per ....The Earth System Dynamics Network for a Sustainable Australia. Earth comprises systems of enormous complexity that sustain all life and control the distribution of mineral, energy and water resources. Thus understanding these dynamic systems provides the key to sustainable resource usage. The aim of The Earth System Dynamics Network is to facilitate scientific interactions through establishment of an earth and environmental sciences grid that links national and regional data assets with high performance computing through open sourced middleware. The result will be an unparalleled predictive capacity for complex Earth systems. The outcome will be confidence in the knowledge that underpins our decisions as stakeholders to keep Australia sustainable.Read moreRead less
Nano-machining of diamond-like carbon (DLC): Scientific basis and technical potential. Nanotechnology will be the basis for the next post-industrial revolution, and will be the main driver of future national economies. It is crucially important that at the very least Australia is a significant niche player in those developments. The project represents an effort to promote those goals.
Sustainable processes for next-generation surface coatings and core-shell nanoparticles based on biomolecular templating. Nanotechnology promises new materials with broad impact, yet our ability to manufacture complex nanomaterials using sustainable processes is very limited. This project will advance our knowledge of nanomaterial manufacture using inspiration from how complex materials are made in nature. This project will deliver next-generation surface coatings that are incredibly thin but st ....Sustainable processes for next-generation surface coatings and core-shell nanoparticles based on biomolecular templating. Nanotechnology promises new materials with broad impact, yet our ability to manufacture complex nanomaterials using sustainable processes is very limited. This project will advance our knowledge of nanomaterial manufacture using inspiration from how complex materials are made in nature. This project will deliver next-generation surface coatings that are incredibly thin but strong, and specialised nanoparticles made using biocompatible processes. The knowledge and methods developed will benefit the biotechnology and nanotechnology sectors, as well as research in soft-matter science, quantum computing, photonics and healthcare. The value proposition for innovation in these fields will increasingly rely on new nanomanufacturing approaches.Read moreRead less
Ethos and Topos: A Philosophical Investigation of the Ethics and Politics of Place. This project will contribute to the public and academic understanding of the way our sense of place relates to our sense of who we are, and the ethical implications of that relation. The outcomes of the project will have an application to a wide range of applied and policy areas in which questions of identity and belonging are at issue. It will connect directly with ongoing public discussion about a number of cr ....Ethos and Topos: A Philosophical Investigation of the Ethics and Politics of Place. This project will contribute to the public and academic understanding of the way our sense of place relates to our sense of who we are, and the ethical implications of that relation. The outcomes of the project will have an application to a wide range of applied and policy areas in which questions of identity and belonging are at issue. It will connect directly with ongoing public discussion about a number of critical contemporary issues relating to ideas of nationhood and community, our connection to land and environment, and our sense of identity and belonging.Read moreRead less
Uncoupling past salinity and temperature signals in the Indo-Pacific Warm Pool: implications for climate change in the Australian region. The tropical oceans and in particular the Indo-Pacific Warm Pool, immediately to Australia's north, play a key role in modulating global and Australian climate through El-Niño and related phenomena. Using a new microanalysis approach to analyse individual foraminifera from deep-sea cores, we will reconstruct past salinity and temperature variability within the ....Uncoupling past salinity and temperature signals in the Indo-Pacific Warm Pool: implications for climate change in the Australian region. The tropical oceans and in particular the Indo-Pacific Warm Pool, immediately to Australia's north, play a key role in modulating global and Australian climate through El-Niño and related phenomena. Using a new microanalysis approach to analyse individual foraminifera from deep-sea cores, we will reconstruct past salinity and temperature variability within the Warm Pool, and determine changing rainfall patterns and, ENSO and monsoon behaviour under climate conditions that lie outside modern records. This information is vital for understanding past climate and predicting the future intensity and frequency of El-Niño related drought and wet cycles in Australia.Read moreRead less
Testing, modelling and engineering applications of topologically interlocking structures. The CI and his international collaborator have recently proposed a new principle of design of materials and structures based on topological interlocking of constituent elements. Elements of simple shape, such as tetrahedra, are assembled in structures that keep their integrity without any binder or connectors. Unusual properties, such as high fracture toughness and damage tolerance were found. The project a ....Testing, modelling and engineering applications of topologically interlocking structures. The CI and his international collaborator have recently proposed a new principle of design of materials and structures based on topological interlocking of constituent elements. Elements of simple shape, such as tetrahedra, are assembled in structures that keep their integrity without any binder or connectors. Unusual properties, such as high fracture toughness and damage tolerance were found. The project aims at investigating the mechanical and acoustic properties of the newly discovered interlockable geometries (cubes, octahedra, dodecahedra and icosahedra) and identifying the areas of application. The project will promote the international leading role of the collaborating institutions in this novel field.Read moreRead less
A NEW CONCEPT IN DESIGN OF MATERIALS AND STRUCTURES BASED ON TOPOLOGICALLY INTERLOCKED ELEMENTS. The project aims to develop a new concept in materials design based on assemblies of interlocked elements. Interlocking is achieved topologically by special arrangements of blocks without connectors. Such assemblies can form structures possessing special mechanical properties and serve as load-bearing skeletons in composites with a binder phase providing desired functional properties. Various types o ....A NEW CONCEPT IN DESIGN OF MATERIALS AND STRUCTURES BASED ON TOPOLOGICALLY INTERLOCKED ELEMENTS. The project aims to develop a new concept in materials design based on assemblies of interlocked elements. Interlocking is achieved topologically by special arrangements of blocks without connectors. Such assemblies can form structures possessing special mechanical properties and serve as load-bearing skeletons in composites with a binder phase providing desired functional properties. Various types of interlocked assemblies will be modelled, produced and tested to determine their mechanical and acoustic properties. A range of experimental techniques tailored for these unusual assemblies will be employed. The expected outcome will be the implementation of the new design principle in multifunctional materials and structures.Read moreRead less